Effectiveness of various hip preservation treatments for non-traumatic osteonecrosis of the femoral head: A network meta-analysis of randomized controlled trials

Background

Non-traumatic osteonecrosis of the femoral head (ONFH) is a refractory osteonecrosis disease caused by an abnormal blood supply to bone tissue. However, therapeutic hip preservation strategies are diverse, and the therapeutic outcomes are not ideal.

L4,5吻合棘并L5右侧浮动半椎板1例报告

正吻合棘(KS)是指腰椎相邻2个棘突相互靠近碰撞引起下腰痛,腰椎过伸时症状加重的一种疾病~([1])。本院2016年收治1例L_(4,5) KS并L_5右侧峡部裂及近横向脊椎隐裂致L_5右侧形成浮动半椎板的病例,现将诊疗过程报告如下。1一般资料患者,男,30岁,因"劳累后下腰部正中及右侧髂腰部疼痛加重1年"就诊。追问病史,12年前新兵训练5 km武装越野时曾出现类似症状,疼痛     

Do Job Demands of Chinese Manufacturing Employees Predict Positive or Negative Outcomes? A Test of Competing Hypotheses

Karasek's job demands–control (JDC) model posits that job control can buffer against the harmful effects of demands experienced by employees. A large volume of JDC research has obtained support for the main effects of demands and control, but not the interactive effects. Recent research on the challenge–hindrance stressors framework, however, found that work stressors may not always be deleterious, suggesting alternative hypotheses about the effects of demands and control. The present study therefore examined competing hypotheses concerning the effects of job demands on occupational health outcomes. Using a sample of 316 employees in a Chinese manufacturing company, we found that, consistent with the challenge–hindrance framework, production demands were challenge stressors associated with favourable outcomes (i.e. job satisfaction and psychological well‐being). In addition, results showed that the interactive role of job control depended on the nature of outcome variables. Future recommendations and implications of findings are discussed. Copyright © 2014 John Wiley & Sons, Ltd.     

Pilot Study Evaluating Regulatory T Cell–Promoting Immunosuppression and Nonimmunogenic Donor Antigen Delivery in a Nonhuman Primate Islet Allotransplantation Model

The full potential of islet transplantation will only be realized through the development of tolerogenic regimens that obviate the need for maintenance immunosuppression. Here, we report an immunotherapy regimen that combines 1‐ethyl‐3‐(3′‐dimethylaminopropyl)‐carbodiimide (ECDI)‐treated donor lymphoid cell infusion (ECDI‐DLI) with thymoglobulin, anti‐interleukin‐6 receptor antibody and rapamycin to achieve prolonged allogeneic islet graft survival in a nonhuman primate (NHP) model. Prolonged graft survival is associated with Treg expansion, donor‐specific T cell hyporesponsiveness and a transient absence of donor‐specific alloantibody production during the period of graft survival. This regimen shows promise for clinical translation.     

湿热交换过滤器的功能及其并发症研究进展

背景 湿热交换过滤器是一类用于代替上呼吸道和鼻功能的人工装置,具有一定程度的保温、保湿和滤过功能.目的 概述湿热交换过滤器及其并发症,为临床医师的合理选择和使用提供参考.内容 通过总结大量的临床和实验室研究文献,客观地讲述呼吸过滤器的三大功能及其影响因素,同时也详细地介绍了可能发生的并发症.趋向 随着临床和实验室研究的深入,湿热交换过滤器会得到进一步的改进和完善.