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91.
Pelacho B Luttun A Aranguren XL Verfaillie CM Prósper F 《Expert opinion on biological therapy》2007,7(8):1153-1165
Cardiovascular diseases are responsible for high morbidity/mortality rates worldwide. Advances in patient care have significantly reduced deaths from acute myocardial infarction. However, the cardiac remodeling processes induced after ischaemia are responsible for a worsening in the heart condition, which in many cases ends up in failure. In the last decade, a novel therapy based on stem cell transplantation is being intensively studied in animal models and some stem cell types (i.e., skeletal myoblasts and bone marrow-derived cells) are already being tested in clinical trials. A novel stem cell population isolated from the bone marrow, termed multipotent adult progenitor cells was characterised a few years ago by its ability to differentiate, at the single cell level, towards cells derived from the three embryonic germ layers. Later on, other pluripotent cell populations have been also derived from the bone marrow. In this overview, the authors outline different stem cell sources that have been tested for their cardiovascular potential and put the regenerative potential of multipotent adult progenitor cells in animal models of acute and chronic myocardial infarction into perspective. 相似文献
92.
Joseba Xabier Huitzi-Egilegor Maria Isabel Elorza-Puyadena Jose Maria Urkia-Etxabe Carmen Asurabarrena-Iraola 《Revista latino-americana de enfermagem》2014,22(5):772-777
OBJECTIVE:
to analyze what nursing models and nursing assessment structures have been used in the implementation of the nursing process at the public and private centers in the health area Gipuzkoa (Basque Country).METHOD:
a retrospective study was undertaken, based on the analysis of the nursing records used at the 158 centers studied.RESULTS:
the Henderson model, Carpenito''s bifocal structure, Gordon''s assessment structure and the Resident Assessment Instrument Nursing Home 2.0 have been used as nursing models and assessment structures to implement the nursing process. At some centers, the selected model or assessment structure has varied over time.CONCLUSION:
Henderson''s model has been the most used to implement the nursing process. Furthermore, the trend is observed to complement or replace Henderson''s model by nursing assessment structures. 相似文献93.
94.
95.
Urra X Planas AM Chamorro A 《Stroke; a journal of cerebral circulation》2012,43(2):e26; author reply e27-e26; author reply e28
96.
We use a minimal model of metabolism-based chemotaxis to show how a coupling between metabolism and behavior can affect evolutionary dynamics in a process we refer to as behavioral metabolution. This mutual influence can function as an in-the-moment, intrinsic evaluation of the adaptive value of a novel situation, such as an encounter with a compound that activates new metabolic pathways. Our model demonstrates how changes to metabolic pathways can lead to improvement of behavioral strategies, and conversely, how behavior can contribute to the exploration and fixation of new metabolic pathways. These examples indicate the potentially important role that the interplay between behavior and metabolism could have played in shaping adaptive evolution in early life and protolife. We argue that the processes illustrated by these models can be interpreted as an unorthodox instantiation of the principles of evolution by random variation and selective retention. We then discuss how the interaction between metabolism and behavior can facilitate evolution through (i) increasing exposure to environmental variation, (ii) making more likely the fixation of some beneficial metabolic pathways, (iii) providing a mechanism for in-the-moment adaptation to changes in the environment and to changes in the organization of the organism itself, and (iv) generating conditions that are conducive to speciation. 相似文献
97.
98.
Since its discovery in 1993 and subsequent development of selective antagonists, a growing number of studies support the use of serotonin 5-HT(6) receptor antagonism as a promising mechanism for treating cognitive dysfunction. Lately, several studies with structurally different compounds have shown that not only antagonists, but also 5-HT(6) receptor agonists improve learning and memory in animal models. There is even an antagonist, SB-742457, that has completed phase II trials for the treatment of Alzheimer's disease. In addition to describe preclinical and clinical evidence of the effect of 5-HT(6) receptor compounds on cognition, this article will also focus on the purported biochemical and neurochemical mechanisms of action by which 5-HT(6) receptor compounds could influence cognition in health and disease. 相似文献
99.
Royl Georg Fokou Tsafack Judicael Chunder Rittika Isa Rakad Münte Thomas F. Wandinger Klaus-Peter Schwaninger Markus Herrmann Oliver Valdueza José Manuel Brocke Jan Willkomm Martin Willemsen Dietrich Auffarth Gerd U. Mindorf Swantje Brix Britta Chamorro Angel Planas Anna Urra Xabier 《Journal of neurology》2019,266(11):2772-2779
Journal of Neurology - Ischemic stroke (IS) and hemorrhagic stroke (HemS) typically lead to a breakdown of the blood–brain barrier with neural antigen presentation. This presentation could... 相似文献
100.
Antoni Dávalos Erik Cobo Carlos A Molina Angel Chamorro M Angeles de Miquel Luis San Román Joaquín Serena Elena López-Cancio Marc Ribó Mónica Millán Xabier Urra Pere Cardona Alejandro Tomasello Carlos Castaño Jordi Blasco Lucía Aja Marta Rubiera Meritxell Gomis M. Hernandez-Pérez 《Lancet neurology》2017,16(5):369-376