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101.
Laura Barrado Carmen Ezpeleta José Miguel Rubio Carmen Martín José Manuel Azcona Miren Arteaga Xabier Beristain Ana Navascués Eva Ongay Jesús Castilla 《Infection》2017,45(1):111-114
In 2014, an autochthonous case of introduced malaria caused by Plasmodium vivax was identified in Spain. The strain that infected this patient was identical to that of a prior imported case from Pakistan. This is the first case where the source of infection could be identified since elimination in Spain. 相似文献
102.
Sabrina Llop Miquel Porta Maria Dolores Martinez Xabier Aguinagalde Mariana F. Fernández Ana Fernández-Somoano Maribel Casas Martine Vrijheid Mikel Ayerdi Adonina Tardón Ferran Ballester 《Gaceta sanitaria / S.E.S.P.A.S》2013
Objective
To describe the time trend in atmospheric lead concentrations in Spain, from before lead was banned as a gasoline additive to the present, and to determine the trend in lead body burden in the Spanish child population.Methods
We obtained the annual average for atmospheric lead levels in several Spanish cities from the 1980s to the present. A literature search was conducted to identify published studies on lead concentrations in populations of Spanish children.Results
Overall, atmospheric lead levels decreased, particularly between 1991 and 1999. This downward trend was related to a decrease in lead concentrations in Spanish children from 1989, the year in which the first study of childhood lead exposure was published, until the present. The decreased concentrations in both air and in children was most probably a result of legislative measures regulating the maximum amount of lead in gasoline in 1987 until a complete ban in August 2001.Conclusions
From a public health point of view, the banning of leaded gasoline has significantly increased health protection in the Spanish population. 相似文献103.
Vera Adema María J. Larráyoz María J. Calasanz Laura Palomo Ana Patiño‐García Xabier Agirre Jesús M. Hernández‐Rivas Eva Lumbreras Ismael Buño Carolina Martinez‐Laperche Mar Mallo Olga García Sara Álvarez Beatriz Blazquez José Cervera Elisa Luño Alberto Valiente María T. Vallespí Leonor Arenillas Rosa Collado Jaime Pérez‐Oteyza Francesc Solé 《British journal of haematology》2015,171(1):137-141
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107.
Carlos Saga Manuel Olalde Ekhiñe Larruskain Leire Álvarez Xabier Altuna 《Acta otorrinolaringologica espanola》2018,69(1):18-24
Introduction and objectives
Interventional endoscopy allows us to act on the pathology of the patient with minimal discomfort, low costs and high efficiency. We assessed the validity of flexible endoscopic biopsies in our hospital, in lesions suspected of malignancy in the rhino-pharyngo-laryngeal space.Subjects and methods
Retrospective study of patients with a pathology suspected of malignancy assessed between 2006-2016 in our centre. We evaluated the effectiveness, the tolerance and the number of complications. We calculated the cost reduction in comparison with direct laryngoscopy in the operating room. We compared our sample with others of similar characteristics described in the literature.Results
Thirty patients were studied with a flexible endoscopic biopsy during that period. Nineteen patients obtained positive results which allowed them to start treatment for their pathology. Seven cases had no evidence of malignancy and required another biopsy under general anaesthesia, which confirmed the carcinoma diagnosis. Two samples ruled out malignancy which was confirmed by laryngeal microsurgery. One case showed inflammation and the lesion was cured after antibiotherapy. It was impossible to collect the sample in one case. Thus, we obtained sensitivity levels of 73% with a specificity of 100%. There were no complications. The cost reduction in our sample was above 80%.Conclusions
Flexible endoscopic biopsy has advantages over direct laryngoscopy that are relevant in the diagnosis of oncological pathology in otorhinolaryngology. 相似文献108.
109.
Chen JS Pardo FS Wang-Rodriguez J Chu TS Lopez JP Aguilera J Altuna X Weisman RA Ongkeko WM 《The Laryngoscope》2006,116(3):401-406
OBJECTIVE: To identify the presence of side population (SP) cells in established head and neck squamous carcinoma cell (HNSCC) lines and to determine the role of EGFR in the regulation of the side population of these cells. METHODS: SP cells were identified using flow cytometry analysis by the ability of these cells to extrude the Hoechst 33342 dye via the drug transporter BCRP1/ABCG2. Effect of EGFR on the side population was determined also by difference in Hoechst extrusion and by immunofluorescence. Immunohistochemical staining was performed to show the presence of the BCRP1/ABCG2 transporter and the phosphorylated form of EGFR in HNSCC tissue. RESULTS: SP cells are present in HNSCC cell lines. With the Hoechst 33342 extrusion assay, SP cells were found to comprise an average of 0.69% of the UMSCC10B cells and 0.91% of HN12 cells. Addition of the EGF ligand increased the SP population while inactivation of the EGFR kinase by Iressa significantly decreased SP. CONCLUSION: In established head and neck squamous cell carcinoma cell lines, SP cells were found using methods that determine expression and function of the drug transporter BCRP1/ABCG2. Activation of EGFR, a gene implicated in tumorigenesis in HNSCC leads to increased SP, and conversely, inhibition of EGFR leads to decrease in SP. This finding could help explain the role of EGFR in regulating cancer stem cells and thus tumorigenesis in HNSCC. 相似文献
110.
Sergio Cardoso Laura Valverde Adrian Odriozola Xabier Elcoroaristizabal Marian M de Pancorbo 《European journal of human genetics : EJHG》2010,18(7):848-851
The field of Biobanking requires extensive work to maintain traceability of samples. However, sometimes the necessity to authenticate a sample may arise. To address these circumstances, we herein present a method for authenticating derivatives by using a blood spot from each donor, attached to a sample authentication form, by means of genetic profiling. Blood spots are collected at the time a blood sample is donated at a health centre and before processing the blood sample at the biobank. To test the validity of our approach over time, we analyzed 26 blood spots stored at room temperature in our facilities for more than 15 years. DNA was successfully extracted from the three storage materials tested in this study and 15 STR markers plus amelogenin were subsequently analyzed. The storage of a small blood spot attached to a sample authentication form proved to be efficient for genetic profiling and, therefore, may constitute a long-lasting (at least 15 years), cost-effective and effortless approach for genetic authentication of samples in biobanks. 相似文献