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81.
Juliana Maier Camila Silveira Sfreddo Ana Paula Pereira Reiniger Karla Zanini Kantorski Ulf ME Wikesj Carlos Heitor Cunha Moreira 《International dental journal》2021,71(2):127
BackgroundPeriodontal disease is a major cause of tooth loss. Few studies have evaluated the residual area of the periodontal ligament in extracted teeth and, to the best of our knowledge, none from Latin America have done so regarding indications for extraction. The aim of this study was to evaluate the residual periodontal ligament (RPL) with respect to indication for extraction in a sample of teeth from a Brazilian Public Health Service district.Materials and methodsAll teeth extracted within the Public Health Service district of Santa Maria, Brazil, over a 5-month period were requested for analysis. A total of 414 teeth eligible for measurement were stained and evaluated for RPL using a stereo microscope. Participating Public Health Service dentists completed a questionnaire detailing demographic variables and indication for each extracted tooth. The percentage of RPL was determined for each tooth. Comparisons of RPL between teeth extracted on periodontal versus other indications were made using the Mann-Whitney test.ResultsRPL averaged 34.8% for teeth extracted on periodontal indications versus 79.5% for other teeth (P ≤ 0.001). When considering teeth with an RPL ≥ 30% as possible to maintain, 189 (76%) of the teeth extracted on periodontal indications could have been maintained. When RPL cut-off limits of ≥ 40% or ≥ 50% are applied, 93 (37%) and 43 (17%) teeth, respectively, could have been maintained.ConclusionThis study suggests that strictly based on RPL, a large number of teeth extracted on periodontal indications conceivably could be maintained.Key words: Cross-sectional studies, Prognosis, Tooth extraction, Tooth loss 相似文献
82.
Patience ME Ocansey Irene A Kretchy Genevieve C Aryeetey Kofi Agyabeng Justice Nonvignon 《Ghana medical journal》2021,55(3):173
ObjectiveThis study assessed levels of anxiety, depression, and stress among family caregivers of children and adolescents with mental disorders in Ghana and the implication on medication adherence.DesignA cross-sectional study.SettingThe study was conducted at the outpatient departments of the three main public psychiatric hospitals in Ghana.ParticipantsTwo hundred and ten non-paid family caregivers of children and adolescents with mental disorders were recruited for this study.Main Outcome MeasureThe study assessed symptoms of anxiety, depression and stress among the caregivers and estimated caregiver-reported medication adherence.ResultsAbout 56.2%, 66.2% and 78% of the caregivers experienced severe anxiety, severe depression and moderate to severe stress symptoms respectively. From the multiple logistic regression model, while anxiety was significantly affected by religion and education, depression was influenced by sex, age, marital status, proximity to facility, and employment status. Female caregivers had about four times higher odds of being depressed compared to male caregivers (aOR: 3.81, 95% CI: 1.66 – 8.75). The caregiver-reported medication adherence was 11.9%. Anxiety was significantly predictive of medication adherence.ConclusionMost family caregivers of children and adolescents with mental disorders experienced symptoms of anxiety, depression and stress with anxiety having implications for medication adherence. The study findings underscore the need to consider psychological characteristics of caregivers and the provision of mental health support for them, as part of the routine health care for children and adolescents with mental disorders.FundingNone indicated 相似文献
83.
Anne J. Keurentjes Kornelis D. de Witt Ivone Jakasa Lars Rüther Patrick M. J. H. Kemperman Sanja Kezic Christoph Riethmüller 《Experimental dermatology》2020,29(5):462-466
Actinic keratosis (AK) is a frequent premalignant skin lesion mainly caused by chronic sun exposure. AK lesions are often surrounded by invisible, subclinical alterations, called field of cancerization (FoC). Definition of FoC is of importance for therapy management; however, the criteria and non-invasive tools to characterize FoC are lacking. Atomic force microscopy (AFM) proved to be a suitable tool for detection of changes in the corneocyte surface topography in inflammatory skin diseases, which share similar clinical features with AK such as hyper- and parakeratosis. Therefore, in this study we applied AFM to investigate AK and surrounding skin obtained by non-invasive collection of the stratum corneum (SC) with adhesive tapes. Furthermore, we determined degradation products of structural protein filaggrin (natural moisturizing factor, NMF), which previously showed association with the changes in corneocyte surface topography. Ten patients with multiple AK on the face were recruited from the outpatient clinic. SC samples were collected from the AK lesion, skin sites adjacent to the AK, 5 cm from the AK and retroauricular area. Corneocyte surface topography was determined by AFM, and NMF by liquid chromatography. The AK lesion showed alterations of the corneocyte surface topography characterized by an increased number of nanosize protrusions, which gradually decreased with the distance from the lesion. NMF levels show an inverse pattern. Atomic force microscopy showed to be a suitable tool to detect changes in the corneocyte surface topography on the AK lesion and surrounding skin in a non-invasive manner. 相似文献
84.
85.
M. Y. Deng M. Sill D. Sturm D. Stichel H. Witt J. Ecker A. Wittmann J. Schittenhelm M. Ebinger M. U. Schuhmann D. Figarella-Branger E. Aronica O. Staszewski M. Preusser C. Haberler M. Lauten U. Schüller C. Hartmann M. Snuderl C. Dunham N. Jabado P. Wesseling M. Deckert K. Keyvani N. Gottardo F. Giangaspero K. von Hoff D. W. Ellison T. Pietsch C. Herold-Mende T. Milde O. Witt M. Kool A. Korshunov W. Wick A. von Deimling S. M. Pfister D. T. W. Jones F. Sahm 《Neuropathology and applied neurobiology》2020,46(5):422-430
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87.
Adrian M. Dubuc Marc Remke Andrey Korshunov Paul A. Northcott Shing H. Zhan Maria Mendez-Lago Marcel Kool David T. W. Jones Alexander Unterberger A. Sorana Morrissy David Shih John Peacock Vijay Ramaswamy Adi Rolider Xin Wang Hendrik Witt Thomas Hielscher Cynthia Hawkins Rajeev Vibhakar Sidney Croul James T. Rutka William A. Weiss Steven J. M. Jones Charles G. Eberhart Marco A. Marra Stefan M. Pfister Michael D. Taylor 《Acta neuropathologica》2013,125(3):373-384
88.
Interobserver reproducibility and agreement with original diagnosis in the categories “atypical” and “suspicious for malignancy” for bile and pancreatic duct brushings 下载免费PDF全文
89.
Teresa Alberts Veronica Antipova Carsten Holzmann Alexander Hawlitschka Oliver Schmitt Jens Kurth Jan Stenzel Tobias Lindner Bernd J. Krause Andreas Wree Martin Witt 《Toxins》2022,14(2)
Olfactory deficits occur as early non-motor symptoms of idiopathic Parkinson’s disease (PD) in humans. The first central relay of the olfactory pathway, the olfactory bulb (OB), depends, among other things, on an intact, functional crosstalk between dopaminergic interneurons and dopamine receptors (D2/D3R). In rats, hemiparkinsonism (hemi-PD) can be induced by unilateral injection of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle (MFB), disrupting dopaminergic neurons of the substantia nigra pars compacta (SNpc). In a previous study, we showed that subsequent injection of botulinum neurotoxin-A (BoNT-A) into the striatum can reverse most of the pathological motor symptoms and normalize the D2/D3R availability. To determine whether this rat model is suitable to explain olfactory deficits that occur in humans with PD, we examined the availability of D2/D3R by longitudinal [18F]fallypride-PET/CT, the density of tyrosine hydroxylase immunoreactivity in the OB, olfactory performance by an orienting odor identification test adapted for rats, and a connectome analysis. PET/CT and immunohistochemical data remained largely unchanged after 6-OHDA lesion in experimental animals, suggesting that outcomes of the 6-OHDA hemi-PD rat model do not completely explain olfactory deficits in humans. However, after subsequent ipsilateral BoNT-A injection into the striatum, a significant 8.5% increase of the D2/D3R availability in the ipsilateral OB and concomitant improvement of olfactory performance were detectable. Based on tract-tracing meta-analysis, we speculate that this may be due to indirect connections between the striatum and the OB. 相似文献
90.
Stroke survivors’ and carers’ experiences of a systematic voiding programme to treat urinary incontinence after stroke 下载免费PDF全文