全文获取类型
收费全文 | 4686篇 |
免费 | 338篇 |
国内免费 | 47篇 |
专业分类
耳鼻咽喉 | 20篇 |
儿科学 | 66篇 |
妇产科学 | 100篇 |
基础医学 | 588篇 |
口腔科学 | 76篇 |
临床医学 | 421篇 |
内科学 | 1108篇 |
皮肤病学 | 75篇 |
神经病学 | 476篇 |
特种医学 | 200篇 |
外科学 | 728篇 |
综合类 | 59篇 |
一般理论 | 1篇 |
预防医学 | 211篇 |
眼科学 | 54篇 |
药学 | 379篇 |
中国医学 | 52篇 |
肿瘤学 | 457篇 |
出版年
2023年 | 36篇 |
2022年 | 79篇 |
2021年 | 133篇 |
2020年 | 68篇 |
2019年 | 128篇 |
2018年 | 116篇 |
2017年 | 95篇 |
2016年 | 135篇 |
2015年 | 157篇 |
2014年 | 207篇 |
2013年 | 262篇 |
2012年 | 384篇 |
2011年 | 379篇 |
2010年 | 258篇 |
2009年 | 213篇 |
2008年 | 286篇 |
2007年 | 281篇 |
2006年 | 206篇 |
2005年 | 213篇 |
2004年 | 174篇 |
2003年 | 150篇 |
2002年 | 124篇 |
2001年 | 84篇 |
2000年 | 79篇 |
1999年 | 77篇 |
1998年 | 36篇 |
1997年 | 22篇 |
1996年 | 32篇 |
1995年 | 25篇 |
1994年 | 12篇 |
1993年 | 16篇 |
1992年 | 44篇 |
1991年 | 53篇 |
1990年 | 43篇 |
1989年 | 37篇 |
1988年 | 42篇 |
1987年 | 44篇 |
1986年 | 38篇 |
1985年 | 33篇 |
1984年 | 29篇 |
1983年 | 26篇 |
1982年 | 17篇 |
1981年 | 18篇 |
1980年 | 16篇 |
1979年 | 22篇 |
1978年 | 27篇 |
1977年 | 21篇 |
1976年 | 12篇 |
1974年 | 17篇 |
1972年 | 12篇 |
排序方式: 共有5071条查询结果,搜索用时 93 毫秒
991.
992.
Yong Chan Ahn Keunchil Park Dae Yong Kim Kwan Min Kim Jhingook Kim Young Mog Shim Kyung Soo Lee Joungho Han Ho Joong Kim O Jung Kwon Do Hoon Lim Young Joo Noh Jeong Eun Lee Seung Jae Huh 《Acta oncologica (Stockholm, Sweden)》2001,40(5):588-592
Thirty-one patients with stage IIIA non-small cell lung cancer (NSCLC) were treated with preoperative concurrent chemoradiotherapy (CCRT) followed by surgery. The treatment protocol could not be completed in eight patients. The acute hematologic toxicities of grade III or IV occurred in 48.4% (15/31) after the first chemotherapy cycle, and in 39.1% (9/23) after the second cycle. The most common non-hematologic toxicity was radiation esophagitis. Surgery was attempted in 23 patients and successful in 22 patients (resection rate = 71.0%). Pathologic complete response and down-staging were achieved in 13.6% (3/22) and 68.2% (15/22). The median survival period, 2-year overall survival, local control and disease-free survival rates of all 31 patients and of 22 patients who underwent surgery were 19 months, 37.2%, 49.1%, 35.5%, and 19 months, 43.2%, 51.8%, 25.6%, respectively. On the basis of our observations, preoperative CCRT followed by surgery for stage IIIA NSCLC has resulted in outcomes comparable with those in previous reports. 相似文献
993.
Prospective evaluation of cancer clinical trial accrual patterns: identifying potential barriers to enrollment. 总被引:6,自引:0,他引:6
P N Lara R Higdon N Lim K Kwan M Tanaka D H Lau T Wun J Welborn F J Meyers S Christensen R O'Donnell C Richman S A Scudder J Tuscano D R Gandara K S Lam 《Journal of clinical oncology》2001,19(6):1728-1733
PURPOSE: Well-conducted cancer clinical trials are essential for improving patient outcomes. Unfortunately, only 3% of new cancer patients participate in clinical trials. Barriers to patient accrual in cancer clinical trials must be identified and overcome to increase patient participation. MATERIALS AND METHODS: We prospectively tracked factors that potentially affected patient accrual into cancer clinical trials at the University of California Davis Cancer Center. Oncologists seeing new outpatients were asked to complete questionnaires regarding patient characteristics and the physician's decision-making on patient eligibility, protocol availability, and patient opinions on participation. Statistical analysis was performed to correlate these parameters with subsequent protocol accrual. RESULTS: There were 276 assessable patients. At the initial visits, physicians did not consider clinical trials in 38% (105/276) of patients principally because of a perception of protocol unavailability and poor performance status. Physicians considered 62% (171/276) of patients for participation in clinical trials. Of these, only 53% (91/171) had an appropriate protocol available for site and stage of disease. Seventy-six of 90 patients (84%) with available protocols met eligibility criteria for a particular study. Only 39 of 76 patients (51%) agreed to participate in cancer clinical trials, for an overall accrual rate of 14% (39/276). The remainder (37/76, 49%) declined trial participation despite meeting eligibility criteria. The most common reasons were a desire for other treatment (34%), distance from the cancer center (13%), patient refusal to disclose reason (11%), and insurance denial (8%). Patients with private insurance were less likely to enroll in clinical trials compared to those with government-funded insurance (OR, 0.34; P =.03; 95% CI, 0.13 to 0.9). CONCLUSION: Barriers to cancer clinical trial accrual can be prospectively identified and addressed in the development and conduct of future studies, which may potentially lead to more robust clinical trials enrollment. Investigation of patient perceptions regarding the clinical trials process and the role of third party-payers is warranted. 相似文献
994.
995.
Viral infections in pregnancy 总被引:1,自引:0,他引:1
Viral infections are a common complication of pregnancy and in some cases, can have profound effects for the unborn fetus. The human herpesvirus family is composed of large, enveloped DNA viruses that have close structural similarity. The family includes the herpes simplex viruses types 1 and 2, varicella zoster virus, Epstein Barr virus, cytomegalovirus (CMV), and human herpes viruses types 6, 7 and 8. These viruses all share the ability to establish latency and reactivate at a later time. Structural fetal abnormalities can result from intrauterine infection and transmission of the infection during the pregnancy or at the time of delivery can result in important neonatal disease. Human parvovirus B19 is a DNA virus with strong tropism for erythroid precursors and infection during pregnancy can result in fetal hydrops and stillbirth. The causative agents of hepatitis are hepatotropic viruses termed hepatitis A, B, C, D (deltavirus) and E. All except hepatitis B virus are RNA viruses. Vertical transmission of maternal infection with hepatitis B and C can result in significant long term sequelae. 相似文献
996.
Ock-Hwa Kim Bo-Yun Choi Dong Kwan Kim Na Hyun Kim Jin Kyung Rho Woo Jun Sul Sei Won Lee 《American journal of cancer research》2022,12(5):2350
Lung cancer is the primary cause of cancer-related deaths worldwide. Recently, although the microbiome has emerged as the key modulator of the carcinogenesis, it has not been evaluated in lung cancer. Here, we evaluated the microbial composition of lung cancer tissues according to the histologic type and genetic mutation, compared it with that of the adjacent normal lung tissues, and investigated the association between the lung microbiome and clinical parameters. We collected lung tissue samples from 162 patients with non-small cell lung cancer (NSCLC, 162 cancer and 54 adjacent normal tissues), surgically resected between January 2018 and December 2019, and analyzed their microbiome using 16S rRNA gene amplicon sequencing, the QIIME2 pipeline, and statistical analyses. NSCLC tissues had significantly lower alpha diversity than the normal tissues, and their microbial composition differed according to the histologic type and cancer genetic mutation. The genera Romboutsia, Novosphingobium, Acinetobacter, and Prevotella were significantly overrepresented in NSCLC tissues. Alpha diversity steadily declined from a normal to a more advanced stage, and microbial compositional differences were noted along with recurrence. Stenotrophomonas was the most predominant genus in the NSCLC tissues of patients with recurrence. The pathways related to the tricarboxylic acid cycle and L-glutamate and L-glutamine biosynthesis were predominant in adenocarcinoma, whereas those related to purine and pyrimidine nucleotide degradation and formaldehyde assimilation were predominant in squamous cell carcinoma. Our findings suggest that the altered lung cancer microbial composition might be associated with cancer initiation and/or progression. 相似文献
997.
Baldwin Pok Man Kwan Anne-Marie Hill Mercedes Elliott Lisa van der Lee 《Hong Kong Physiotherapy Journal》2022,42(1):55
Background:Pneumonia is a frequent diagnosis for patients admitted to Australian intensive care units (ICUs) for invasive ventilation. Physiotherapists in ICU provide interventions to enhance respiratory function and physical recovery.Objective:This retrospective cohort study aimed to describe physiotherapy management of adults with pneumonia who require invasive mechanical ventilation in a single Level 3 ICU in a quaternary teaching hospital.Methods:All adults admitted with a medical diagnosis of pneumonia requiring invasive mechanical ventilation over a two-year period were included. Demographic and clinical data, including APACHE II score, ventilator-free days (VFDs) to day 28, ICU length of stay (LOS), and type and frequency of physiotherapy episodes of care delivered in ICU, were collected from electronic medical records. Correlations between VFDs to day 28 and the frequency of physiotherapy interventions delivered per subject were examined using Spearman’s rho analysis.Results:From 208 records screened, 66 subjects with an ICU admission diagnosis of pneumonia, who required invasive mechanical ventilation, were included. Median (IQR) ICU LOS was 10 (5–17) days, and mortality rate was 15.2% (). The cohort had a median of 20.5 (IQR 2–25) VFDs to day 28. Community-acquired pneumonia (66.7%, ) was the most frequent type of pneumonia diagnosis. There were 1110 episodes of physiotherapy care, with patients receiving a median of 13.5 (IQR 6.8–21.3) episodes during their ICU stay, with a median rate of 1.2 (IQR 1.0–1.6) episodes per day. Over 96.7% of patients with pneumonia received physiotherapy treatment during their ICU stay. Overall, physiotherapy treatments consisting only of respiratory techniques were most commonly provided (55.1%, ). Airway suctioning (92.4%, ), patient positioning (72.7%, ) or positioning advice to nurses (77.3%, ), and hyperinflation techniques (63.6%, ) were among the respiratory techniques most delivered.Conclusion:This study described the current intensive care physiotherapy management in a single center for adults with pneumonia who required invasive mechanical ventilation, demonstrating that respiratory physiotherapy interventions are often provided for this ICU patient cohort. Further research is warranted to determine the efficacy of respiratory physiotherapy interventions to justify their use for ICU patients with pneumonia receiving invasive mechanical ventilation. 相似文献
998.
CHEING Chor Kwan LAU Kwok Kwong YU Kwok Wai CHAN Yan Wo Albert MAK Miu Chloe 《中华医学杂志(英文版)》2010,123(11):1469-1469
Charcot-Marie-Tooth disease (CMT), also known as hereditary motor and sensory neuropathies,comprises a genetically heterogeneous group of inherited peripheral neuropathies. Clinically it is characterized by progressive distal weakness, muscle atrophy, distal sensory loss and loss of deep tendon reflexes. Following electrophysiological criteria, CMT is divided into two main forms: 相似文献
999.