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31.
32.
Steffel J Wernig M Knauf U Kumar S Wiestler OD Wernig A Brüstle O 《Stem cells (Dayton, Ohio)》2003,21(2):181-189
There is increasing evidence that muscle-derived precursor cells can, under appropriate conditions, give rise to other than myogenic cell types. Transplantation into the embryonic ventricular zone provides a unique opportunity to study the migration and differentiation of non-neural somatic progenitor cells in response to instructive cues within the developing neuroepithelium. Here, we demonstrate that myogenic cell lines grafted into the ventricles of rat embryos showed widespread migration into several host brain compartments. In contrast to incorporation patterns observed after transplantation of neural cells, grafted myoblasts incorporated virtually exclusively along endogenous blood vessels. Preferential incorporation sites included cortex, olfactory bulb, hippocampus, striatum, thalamus, hypothalamus, and tectum. While the engrafted myoblasts showed no evidence of neural differentiation, a fraction exhibited pronounced coexpression of endothelial marker antigens. These findings support the concept of a close developmental relationship between the myogenic and the endothelial lineages. Used as a delivery system, transfected myoblasts may be exploited for widespread gene transfer to the perivascular compartment of the perinatal central nervous system. 相似文献
33.
Ependymome entstehen aus den
wandauskleidenden Ependymzellen der Ventrikel einschließlich des
Zentralkanals des Rückenmarks. Entsprechend können sie
ventrikelnah im Bereich des Gehirns sowie im Inneren des
Rückenmarks und an dessen Ende, dem Filum terminale, beobachtet
werden. Sie stellen ca. 3–9% aller neuroepithelialen
Tumoren,wobei der Anteil im Kindesalter deutlich höher ist—hier
machen sie bis zu 20% aller soliden intrakraniellen Tumoren aus.
In dem vorliegenden Text sollen die intrakraniellen Ependymome
behandelt werden—auf die spinalen Ependymome, die in der Regel
als intramedulläre Tumoren auftreten, soll aufgrund der
grundsätzlichen Verschiedenheiten spinaler und intrakranieller
Tumoren hier nicht eingegangen werden. Die intrakraniellen
Manifestationen der Ependymome führen zu Anfällen oder zu
neurologischen Ausfallserscheinungen. Je nach Lage des Tumors,
insbesondere bei Lokalisation des Tumors in der hinteren
Schädelgrube tritt häufig ein begleitender Hydrozephalus auf.
Die Therapie der Wahl ist die mikrochirurgische Exstirpation,
die auf eine maximale Entfernung des Tumors abzielt. Rezidive
entstehen in der Regel lokal, selten auch als Aussaat über den
Liquorraum. Aufgrund der Rezidivneigung ist eine regelmäßige
Nachsorge unerlässlich. 相似文献
34.
Jung G Brandl M Eisner W Fraunberger P Reifenberger G Schlegel U Wiestler OD Reulen HJ Wilmanns W 《International journal of cancer. Journal international du cancer》2001,91(2):225-230
After adoptive transfer of pre-activated lymphocytes into the operation cavity of glioma patients, tumor regression and improved survival have been reported in some patients. Results were most impressive when bispecific antibodies with tumor x CD3 specificity were also applied. In this study, we attempted to avoid time-consuming pre-activation procedures for adoptively transferred cells by using a combination of bispecific antibodies directed to the EGF receptor (EGFR) on tumor cells and to CD3 and CD28 on T cells. Eleven patients with high-grade malignant glioma received 3 injections of 2 bispecific antibody fragments (EGFR x CD3 and EGFR x CD28) together with freshly isolated autologous lymphocytes via an Ommaya reservoir. Intracavitary fluid aspirated during immunotherapy was examined for markers of T-cell activation. Increased levels of soluble IL-2 receptor and TNF-alpha were detected in the intracavitary fluid of all patients tested. Two of the 11 treated patients experienced a beneficial response to therapy as defined by a transient contrast enhancement in subsequent MRI scans and prolonged survival. Side effects were transient and consisted of fever, nausea, headache and aggravation of pre-existing neurologic deficits. These adverse effects were most likely due to the antibody construct containing anti-CD3 specificity. Two patients developed cerebral edema and required steroid treatment. 相似文献
35.
36.
M M Valter A Hügel H J Huang W K Cavenee O D Wiestler T Pietsch N Wernert 《Cancer research》1999,59(21):5608-5614
37.
38.
39.
40.
Dr. I. Bueno-Gimeno OD Dr. E. España-Gregori PhD R. Montés-Micó OD Dr. M. Diaz-Llopis PhD Dr. J. L. Menezo-Rozalén PhD 《Annals of Ophthalmology》2002,34(2):113-117
This study determined the amplitude of accommodation in patients with advanced acquired immunodeficiency syndrome (AIDS).
The Push-up and Minus lens techniques were used to measure the accommodation amplitude of 42 patients with AIDS, aged 17 to
44 years, and of aged-matched controls. With both techniques, the AIDS group had average accommodative values below those
of the controls and below normal values. Insufficiency of accommodation in patients with AIDS was more severe in younger than
in older patients.
The authors have stated that they do not have a significant financial interest or other relationship with any product manufacturer
or provider of services discussed in this article. 相似文献