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71.
Matteo Brunelli John N Eble Shaobo Zhang Guido Martignoni Liang Cheng 《Modern pathology》2003,16(10):1053-1059
It has been suggested that gains of chromosomes 7 and 17 and loss of Y occur in renal papillary adenoma and that progression to papillary renal cell carcinoma is marked by gains of additional chromosomes, most frequently 12, 16, and 20. Previous studies have included very few lesions of <5 mm in diameter, a requirement of the present definition of papillary adenoma. Ten papillary adenomas (ranging from 1 to 5 mm in diameter) from autopsy material and 10 surgically resected papillary renal cell carcinomas were studied with fluorescence in situ hybridization in paraffin sections using centromeric probes for chromosomes 7, 12, 16, 17, 20, and Y diluted 1:100 with tDenHyb1 buffer. The signals in 50 to 150 nuclei were counted in each tumor. Controls for all the probes were normal renal tissues from the same patients. Three or more signals per nucleus were frequently observed in papillary adenomas: chromosome 7 (range, 10 to 50%; > or = 30% in 9 of 10), 17 (range, 10 to 47%; > or = 30% in 7), 16 (range, 1 to 63%; > or = 10% in 5), 12 (range, 0 to 32%; > or =10% in 4), and 20 (range, 5 to 49%; > or = 10% in 5). Loss of the Y chromosome was observed in 80 to 90% of nuclei in 9 adenomas from males. Three or more signals were frequent in papillary renal cell carcinomas: chromosome 7 (range, 32 to 63%; > or =30% in 10 of 10), 17 (range, 28 to 61%; > or = 30% in 7), 16 (range, 0 to 45%; > or = 10% in 6), 12 (range, 1 to 37, > or = 10% in 5), 20 (range, 2 to 44%; > or = 10% in 4). No signal for Y was observed in 12 to 88% (> or = 81% in 6) of nuclei in 7 carcinomas from males. Statistical analysis showed no difference between adenomas and carcinomas. Gains of chromosomes 7, 17, 16, 12, and 20 and loss of the Y chromosome occur early in the evolution of papillary renal cell neoplasia in tumors that are only a few millimeters in diameter. Progressive gains of these chromosomes do not appear to correlate with the transition from adenoma to carcinoma. 相似文献
72.
Percutaneous transluminal coronary angioplasty in a patient with paroxysmal nocturnal hemoglobinuria
Ping-Ching Fong Yau-Ting Tai Chu-Pak Lau John Li Florence Hiu-Yee Yap Raymond Liang Albert Kwok-Wai Lie 《Catheterization and cardiovascular interventions》1992,25(2):144-147
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired chronic hemolytic anemia associated with an unusual susceptibility to hemolytic crisis, infection, and venous thrombosis which would be aggravated by a number of factors including surgery. We report a case of PNH undergoing percutaneous transluminal coronary angioplasty and discuss the corresponding perioperative management. 相似文献
73.
Twenty-seven in-patients with obstetric DIC in our hospital from Jan. 1971 to Dec. 1990 were analysed retrospectively. The incidence was 0.12% in the first decade and 0.02%, in the second, showing a difference of significance between them. The most common predisposing factors included amniotic fluid embolism, abruptio placenta and hemorrhagic shock. Bleeding from multi-organs in various extent and coagulation disorders occurred in all those 27 cases. [Besides anti-shock treatment, heparin was employed together with fibrinogen in 4 postpartum and 1 antepartum DIC patients, fibrinogen alone in 8 cases, and hysterectomy in 11 cases. 17 patients were saved and 9 died. It is important that early diagnosis and much attention paid to clinical characteristics together with serial laboratory tests. Key management should include prompt treatment and eradication of predisposing factors. Quick decision spite of to terminate the pregnancy and even hysterectomy should be done in some risks. 相似文献
74.
采用大鼠30%Ⅲ度烫伤模型,应用光镜、电镜、3β-羟甾脱氢酶(3β-HSD)组织化学染色及其相对活性的测定和血清睾酮及黄体生成素(LH)浓度的检测,分不同时相对严重烫伤后30天内大鼠睾丸间质细胞的改变进行了动态观察。结果表明,烫伤后睾丸间质细胞有不同程度的变性、坏死;间质细胞内3β-HSD活性迅速降低,伤后30天仍保持较低水平;血清睾酮水平迅速下降,并持续维持较低水平,伤后30天仍不回升,而血清LH浓度无明显改变。提示烫伤后血清睾酮下降的机理可能与睾丸间质细胞的受损及糖皮质激素升高有关。 相似文献
75.
G K Scriba J A Hower N Y Liang P V Fennessey R T Borchardt 《The Journal of pharmacology and experimental therapeutics》1988,247(2):609-616
The effect of ibopamine (IBO) (SB 7505, SK&F 100168-A), a new drug for the treatment of congestive heart failure, and its active metabolite epinine (EPN) (N-methyldopamine), on the catecholamine content of hypothalamus and brainstem was studied in vitro after monoamine oxidase inhibition with pargyline. IBO and EPN increased levels of epinephrine (EPI) in a concentration- and time-dependent manner in both brain areas without significantly affecting the concentration of other catecholamines. Inhibition of either dopamine beta-hydroxylase, the neuronal EPI and norepinephrine uptake system, or esterase hydrolysis of IBO prevented the increase of EPI, whereas inhibition of phenylethanolamine N-methyltransferase, enzymatic dealkylation or the neuronal dopamine or serotonin uptake system had no influence on the increase of EPI levels. These results suggest that IBO after hydrolysis to EPN can be converted enzymatically to EPI by dopamine beta-hydroxylase in hypothalamus and brainstem. EPN seems to be accumulated into adrenergic and noradrenergic neurons by the high affinity uptake system. Changes in the EPI content of the central nervous system neurons might be responsible for some of the pharmacologic effects of IBO. 相似文献
76.
77.
中药治疗激素依赖性肾病综合征98例 总被引:2,自引:0,他引:2
肾病综合征是由多种病因引起的以大量蛋白尿、低蛋白血症、高度浮肿、高脂血症为临床特点的一组症状群,其基本病理缺陷是肾小球毛细血管基底膜通透性增加,属于中医“水肿”范畴。 相似文献
78.
The immediate, short-term and long-term depressor effects, the immediate effects on cardiac functions in grade II and grade III vascular hypertension, and the effects on angiotensin II in grade III vascular hypertension by acupuncture at otoacupoint Heart were studied in 30 cases of vascular hypertensive patients. The immediate depressor effect of acupuncture at otoacupoint Stomach was also recorded for comparison. It was found that acupuncture at otoacupoint Heart produced marked immediate depressor effect, and the short-term effective rate was 100%, the long-term effective rate was 63.3%, as well as evident immediate effects on cardiac functional activities in grade II and grade III hypertension and marked effects on angiotensin II in grade III hypertension. Acupuncture at otoacupoint Stomach produced no depressor effect on vascular hypertension. 相似文献
79.
80.
观察了30例伴有高脂血症的Ⅱ型糖尿病患者用小剂量乐脂平(500mg/d)治疗4周后血清脂质、脂蛋白的变化。结果:血总胆固醇、甘油三酯及极低密度脂蛋白—胆固醇水平较治疗前下降,高密度脂蛋白—胆固醇明显升高,血糖、血肌酐及血尿酸无明显变化。服用该药未观察到不良反应,提示乐脂平能较好地改善糖尿病患者的脂代谢紊乱。 相似文献