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91.
卒中急性期病人中医综合康复护理效果观察 总被引:2,自引:1,他引:1
[目的]探讨中医综合康复护理对卒中急性期病人神经功能缺损及日常生活能力(ADL)的影响。[方法]选择2004年9月-2006年9月在3家协作医院住院的卒中急性期238例病人为研究对象,随机分为实验组和对照组,两组药物治疗基本相同。实验组按中医综合康复护理方案进行护理.对照组采用卒中护理常规进行护理。对入选的病人在入院第1周内和4周后进行神经功能缺损及ADL的评定。[结果]4周后实验组在临床神经功能缺损、ADL等方面明显优于对照组,差异有统计学意义(P〈0.01)。[结论]中医综合康复护理可促进肢体的功能恢复,提高病人的ADL。 相似文献
92.
Michael D Seidman Mumtaz J Khan Wen Xue Tang Wayne S Quirk 《Otolaryngology--head and neck surgery》2002,127(3):138-144
OBJECTIVES: Lecithin is a polyunsaturated phosphatidylcholine (PPC), which are high energy functional and structural elements of all biologic membranes. PPC play a rate-limiting role in the activation of numerous membrane-located enzymes, including superoxide dismutase and glutathione, which are important antioxidants protecting cell membranes from damage by reactive oxygen species (ROS). ROS-induced damage to mitochondrial DNA may lead to reduced mitochondrial function in the cochlea and resultant hearing loss. STUDY DESIGN AND SETTING: The effects of lecithin on aging and age-associated hearing loss were studied in rats by measuring hearing sensitivities using auditory brainstem responses (ABR). In addition, mitochondrial function as a measure of aging was assessed by determining mitochondrial membrane potentials using flow cytometry and by amplifying mitochondrial DNA deletions associated with aging. Harlan-Fischer rats aged 18 to 20 months (n = 14) were divided into 2 groups. The experimental group was supplemented orally for 6 months with lecithin, a purified extract of soybean phospholipid (Nutritional Therapeutics, Allendale, NJ). RESULTS: The data obtained were compared with the control group. ABRs were recorded at 2-month intervals and showed significant preservation of hearing sensitivities in the treated subjects. Flow cytometry revealed significantly higher mitochondrial membrane potentials in the treated subjects, suggesting preserved mitochondrial function. Finally, the common aging mitochondrial DNA deletion (mtDNA(4834)) were amplified from brain and cochlear tissue including stria vascularis and auditory nerve. This specific deletion was found significantly less frequent in all tissues in the treated group compared with the controls. CONCLUSION: These experiments support our hypothesis and provide evidence that lecithin may preserve cochlear mitochondrial function and protect hearing loss associated with aging. 相似文献
93.
目的:探讨冠心病心力衰竭对各种室性心律失常的影响。方法:选择381例冠心病住院患者,根据心功能分级标准(NYHA)分为4组,检测24h动态心电图(Holter),分析室性心律失常类型及发生率,进行统计分析。结果:各级心功能组其室性心律失常发生率经x^2检验示,室性心律失常的发生率除联律和持续性或非持续性室性心动过速外各组间差异无显著性(P>0.05)。结论:非心肌梗死冠心病患者室性心律失常发作频率与心力衰竭的程度无关,但联律和持续或非持续性室性心动过速在重度心力衰竭患者发生率增加。 相似文献
94.
经阴道超声诊断子宫内膜癌 总被引:1,自引:0,他引:1
目的 探讨应用经阴道超声(TVS)诊断绝经前后出血妇女子宫内膜癌的价值。方法 采用彩色多普勒超声诊断仪检测74例阴道异常出血的妇女,其中绝经前28例,绝经后46例,所有患者均取子宫内膜组织行病理对照。结果 TVS检测子宫内膜癌的敏感性、特异性、假阳性率、假阴性率、阳性预测值和阴性预测值,绝经前妇女依次为61.5%,50.0%,14.3%,23.8%,94.1%和54.5%,绝经后妇女依次为97.3%,55.6%,44.4%,2.7%,90.0%和83.0%。结论 TVS检测可作为子宫内膜癌首选的筛查方法,尤其对于绝经后妇女价值更大。 相似文献
95.
目的:探讨MRI对先天性胆脂瘤的诊断价值。方珐:回顾性分析7例经手术病理证实的先天性胆脂瘤的MRI表现,7例均为脑外型,其中6例胆脂瘤位于桥小脑角区,l例胆脂瘤位于脊髓内.结果:先天性胆脂瘤的绝大多数MRI表现为T1WI呈低信号,T2WI呈高信号,信号欠均匀,且病灶具有“见缝就钻”的特点。增强扫描,病灶无强化,但如合并感染可有轻度强化。结论:MRI的表现及特殊序列FLAIR、SPIR像的相互补充应用对先天性胆脂瘤的诊断及鉴别诊断具有重要意义。 相似文献
96.
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98.
Ming Li Allison Martin Cheng Wen Steven W. Turner Lynley K. Lewis Judith A. Whitworth 《Clinical and experimental pharmacology & physiology》1995,22(12):919-923
1. We tested the ability of ouabain to cause chronic hyper tension by continuously infusing ouabain for 28 days (mini-osmotic pump implantation; i.p.). The blood pressure and metabolic effects of sham (150 mmol/L NaCI; n= 12) or ouabain infusion (10 μg/kg per day; n= 14; 100 μg/kg per day; n = 14) were examined in conscious Sprague-Dawley rats. 2. Plasma ouabain concentrations measured after 28 days of ouabain infusion were as follows: sham, not detectable (n= 11); ouabain 10 μg/kg per day, 0.60 ± 0.07 nmol/L (n= 14); and ouabain 100 μg/kg per day, 7.17 ± 0.57 nmol/L (n= 14; P < 0.001). 3. Sham or ouabain infusion did not alter food intake, bodyweight, water intake or urine output in conscious rats. 4. Blood pressure was not altered by sham treatment. Ouabain at 10 μg/kg per day or 100 μg/kg per day did not produce consistent rises in blood pressure. Ouabain at 10 μg/kg per day increased blood pressure on treatment day 12 only (+ 6mmHg; P < 0.05), while at 100μg/kg per day blood pres sure increased on treatment days 16 (+ 9 mmHg; P < 0.05) and day 18 (+ 8mmHg; P < 0.05) only. There was no significant difference in blood pressure between sham and ouabain groups. 5. Renal blood flow was decreased in rats infused with ouabain at 10 μg/kg per day (2.0 ± 0.3 mL/min per 100 g body-weight; n= 5; P < 0.01) and 100 μg/kg per day (2.2 ± 0.4 mL/ min per 100 g bodyweight; n= 7; P < 0.05) compared with sham treatment (3.5 ± 0.2 mL/min per 100 g bodyweight; n= 6). Renal vascular resistance was increased in rats treated with ouabain at 10 μg/kg per day (65.5 ± 12.6 mmHg/mL per min per 100 g bodyweight; n= 5; P < 0.01) and 100 μg/kg per day (66.0 ± 15.6 mmHg/mL per min per 100 g bodyweight; n= 7; P < 0.05) compared with sham treatment (32.6 ± 2.5 mmHg/mL per min per 100 g bodyweight; n= 6). 6. High plasma concentrations of ouabain do not cause consistent increases in blood pressure in conscious Sprague-Dawley rats. 相似文献
99.
锌对新生大鼠海马培养神经元生长发育的作用 总被引:13,自引:0,他引:13
采用无血清培养的新生大鼠海马神经细胞,观察锌对脑细胞生长发育的作用。结果表明,锌能促进体外培养海马神经元的神经突起生长,突起数增多;神经元的活存数和神经元胞体的直径和面积增加。用流式细胞术分析证明,神经元总蛋白含量增高。本结果提示,锌对海马神经元的生长发育具有促进作用 相似文献
100.
粒细胞集落刺激因子治疗大鼠局灶性脑缺血再灌注损伤 总被引:5,自引:0,他引:5
OBJECTIVE: To study the therapeutic effects of granulocyte colony-stimulating factor (G-CSF) on focal cerebral ischemia-reperfusion injury in rats. METHODS: Adult male SD rats were subjected to transient (2 h) middle cerebral artery occlusion (MCAO) and scored 48 h later for such neurological functions as spontaneous movement, paresis, forelimb motor function, climbing ability, pain sensation, and position sense. Twenty rats with the total score less than 12 were divided equally into two groups to receive daily subcutaneous injection of 20 microg/kg of G-CSF for 19 days or the same dose of saline injection (control group). The rats in the two groups were also given intraperitoneal injection of Brdu10 mg/kg for 19 days. The neurological functions of the rats in both groups were examined on a weekly basis after MCAO and on day 21, the rats were killed to prepare frozen sections of the brain tissues for double immunohistochemical staining with Brdu and glial fibrillary acidic protein antibody to identify the neural cells newly evolved from the stem cells. RESULTS: The rats in G-CSF group showed better neurological function recovery than the control rats 3 weeks after MCAO (P<0.05). Obvious regeneration of the neural cells was observed around the infarction area in the rats receiving G-CSF treatment. CONCLUSION: G-CSF promotes neurological function recovery and neural cell regeneration after cerebral infarction in rats and can be effective for intervention of focal cerebral ischemia-reperfusion injury. 相似文献