全文获取类型
收费全文 | 1384篇 |
免费 | 73篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 66篇 |
妇产科学 | 27篇 |
基础医学 | 164篇 |
口腔科学 | 30篇 |
临床医学 | 78篇 |
内科学 | 305篇 |
皮肤病学 | 19篇 |
神经病学 | 57篇 |
特种医学 | 163篇 |
外国民族医学 | 2篇 |
外科学 | 178篇 |
综合类 | 80篇 |
预防医学 | 63篇 |
眼科学 | 10篇 |
药学 | 69篇 |
中国医学 | 34篇 |
肿瘤学 | 109篇 |
出版年
2023年 | 3篇 |
2022年 | 16篇 |
2021年 | 37篇 |
2020年 | 13篇 |
2019年 | 24篇 |
2018年 | 37篇 |
2017年 | 27篇 |
2016年 | 31篇 |
2015年 | 35篇 |
2014年 | 39篇 |
2013年 | 67篇 |
2012年 | 82篇 |
2011年 | 96篇 |
2010年 | 86篇 |
2009年 | 69篇 |
2008年 | 50篇 |
2007年 | 58篇 |
2006年 | 42篇 |
2005年 | 27篇 |
2004年 | 27篇 |
2003年 | 21篇 |
2002年 | 24篇 |
2001年 | 25篇 |
2000年 | 25篇 |
1999年 | 29篇 |
1998年 | 42篇 |
1997年 | 35篇 |
1996年 | 37篇 |
1995年 | 41篇 |
1994年 | 25篇 |
1993年 | 21篇 |
1992年 | 6篇 |
1991年 | 9篇 |
1990年 | 19篇 |
1989年 | 33篇 |
1988年 | 19篇 |
1987年 | 20篇 |
1986年 | 28篇 |
1985年 | 12篇 |
1984年 | 16篇 |
1983年 | 16篇 |
1982年 | 13篇 |
1981年 | 14篇 |
1980年 | 16篇 |
1979年 | 5篇 |
1978年 | 9篇 |
1977年 | 4篇 |
1976年 | 8篇 |
1975年 | 8篇 |
1916年 | 2篇 |
排序方式: 共有1466条查询结果,搜索用时 0 毫秒
991.
992.
Bassant M. Barakat Qi‐En Wang Chunhua Han Keisha Milum De‐Tao Yin Qun Zhao Gulzar Wani El‐Shaimaa A. Arafa Mohamed A. El‐Mahdy Altaf A. Wani 《International journal of cancer. Journal international du cancer》2010,127(4):977-988
Cisplatin is one of the most widely used anticancer agents, displaying activity against a wide variety of tumors. However, development of drug resistance presents a challenging barrier to successful cancer treatment by cisplatin. To understand the mechanism of cisplatin resistance, we investigated the role of damaged DNA binding protein complex subunit 2 (DDB2) in cisplatin‐induced cytotoxicity and apoptosis. We show that DDB2 is not required for the repair of cisplatin‐induced DNA damage, but can be induced by cisplatin treatment. DDB2‐deficient noncancer cells exhibit enhanced resistance to cell growth inhibition and apoptosis induced by cisplatin than cells with fully restored DDB2 function. Moreover, DDB2 expression in cisplatin‐resistant ovarian cancer cell line CP70 and MCP2 was lower than their cisplatin‐sensitive parental A2780 cells. Overexpression of DDB2 sensitized CP70 cells to cisplatin‐induced cytotoxicity and apoptosis via activation of the caspase pathway and downregulation of antiapoptotic Bcl‐2 protein. Further analysis indicates that the overexpression of DDB2 in CP70 cells downregulates Bcl‐2 expression through decreasing Bcl‐2 mRNA level. These results suggest that ovarian cancer cells containing high level of DDB2 become susceptible to cisplatin by undergoing enhanced apoptosis. 相似文献
993.
E K Seo N C Kim Q Mi H Chai M E Wall M C Wani H A Navarro J P Burgess J G Graham F Cabieses G T Tan N R Farnsworth J M Pezzuto A D Kinghorn 《Journal of natural products》2001,64(11):1483-1485
A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain (3), and a known isoflavone, formononetin (4), were identified as inactive constituents. Compound 1 was evaluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest dose (25 mg/kg body weight) tested. 相似文献
994.
995.
Kareem Masrat Nabi Bushra Kashtwari Mahpara Wani Aijaz A. Dhar Manoj K. 《Proceedings of the National Academy of Sciences, India. Section B.》2019,89(4):1213-1217
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences - Saffron reproduces vegetatively; hence, improvement through breeding is difficult. From the last few decades,... 相似文献
996.
Background: Annually, 1.8 million New York (NY) residents experience substance use disorders (SUDs). Even though emergency departments (EDs) continue to experience high numbers of SUD-related visits, only 15% receive treatment. Objectives: This study estimates hospital-based EDs rates for SUDs in the State of New York. Also, the geographic distribution of substance use treatment centers and EDs are mapped to correlate utilization with access to care. Methods: The 2011–2013 Healthcare Cost and Utilization Project’s NY State Emergency Department Database provided information on utilization of services in EDs, charges, diagnoses, and discharge, as well as patient demographic variables. All patients within NY who had visited the ED for SUDs comprised the study population. Geographic mapping of EDs and substance abuse treatment centers at the county-level is based on data from the National Emergency Department Inventory and National Survey of Substance Abuse Treatment Services, respectively. Results: A total of 492,419 ED visits for SUDs were reported through 2011–2013. Despite NY’s Medicaid expansion in 2012, ED visits increased in 2013. About $856 million was spent in treating SUDs in EDs, with average charge of $1,764 per visit. Conclusions/Importance: Alcohol and drug-induced mental disorders are increasingly prevalent in New York’s EDs. There is a need to develop health policies and programs to improve access to care for SUDs in urban states. 相似文献
997.
Mohd Younus Wani N. A. Ganie D. M. Wani Ab Waheed Wani S. Q. Dar Afzal Husain Khan Nadeem A Khan Mohammad Saood Manzar Mohammad Hadi Dehghani 《Phytotherapy research : PTR》2023,37(3):1136-1152
In Asia, mulberry has long been used to treat various infectious and internal ailments as a traditional medication. The compounds found in it have the potential to improve human health. Because there is no approved and defined evaluation procedure, it has not been formally or scientifically recognized. As a result of these investigations, a new frontier in traditional Chinese medicine has opened up, with the possibility of modernization, for the interaction between active components of mulberry and their biological activities. These studies have used current biotechnological technologies. For ages, mulberry has been used as an herbal remedy in Asia to cure various diseases and internal disorders. It has a high concentration of bioactive chemicals that benefit human health. The most abundant phenolic components extracted from white mulberry leaves are flavonoids (Kuwanons, Moracinflavans, Moragrols, and Morkotins), phenolic acids, alkaloids, and so forth. Flavonoids, benzofurans, chalcones, and alkaloids have been discovered to have cytotoxic effects on human cancer cell lines. There is growing evidence that mulberry fruits can potentially prevent cancer and other aging-related disorders due to their high concentration of bioactive polyphenolic-rich compounds and macro and micronutrients. Anthocyanins are rapidly absorbed after eating, arriving in the plasmalemma within 15–50 min and entirely removed after 6–8 hr. Due to a lack of an approved and consistent technique for its examination, it has yet to be formally or scientifically recognized. The mulberry plant is commercially grown for silkworm rearing, and less attention is paid to its bioactive molecules, which have a lot of applications in human health. This review paper discusses the phenolic compounds of white mulberry and black mulberry in detail concerning their role in cancer prevention. 相似文献
998.
999.
Sadananda Meher Wani Hamza Bruno Mohammad Ibrarullah 《The Indian journal of surgery》2018,80(3):294-295
We report a large, asymptomatic, intraperitoneal loose body in a 72-year-old male, presented with bilateral inguinal hernia. 相似文献
1000.