全文获取类型
收费全文 | 7201篇 |
免费 | 386篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 168篇 |
儿科学 | 272篇 |
妇产科学 | 300篇 |
基础医学 | 1154篇 |
口腔科学 | 116篇 |
临床医学 | 590篇 |
内科学 | 1326篇 |
皮肤病学 | 345篇 |
神经病学 | 581篇 |
特种医学 | 298篇 |
外科学 | 1173篇 |
综合类 | 34篇 |
一般理论 | 6篇 |
预防医学 | 281篇 |
眼科学 | 117篇 |
药学 | 492篇 |
中国医学 | 1篇 |
肿瘤学 | 339篇 |
出版年
2022年 | 44篇 |
2021年 | 78篇 |
2020年 | 49篇 |
2019年 | 78篇 |
2018年 | 91篇 |
2017年 | 76篇 |
2016年 | 105篇 |
2015年 | 107篇 |
2014年 | 135篇 |
2013年 | 206篇 |
2012年 | 273篇 |
2011年 | 312篇 |
2010年 | 198篇 |
2009年 | 200篇 |
2008年 | 284篇 |
2007年 | 314篇 |
2006年 | 304篇 |
2005年 | 311篇 |
2004年 | 291篇 |
2003年 | 244篇 |
2002年 | 260篇 |
2001年 | 209篇 |
2000年 | 271篇 |
1999年 | 189篇 |
1998年 | 70篇 |
1997年 | 79篇 |
1996年 | 71篇 |
1995年 | 59篇 |
1994年 | 42篇 |
1993年 | 47篇 |
1992年 | 140篇 |
1991年 | 137篇 |
1990年 | 137篇 |
1989年 | 113篇 |
1988年 | 89篇 |
1987年 | 84篇 |
1986年 | 87篇 |
1985年 | 92篇 |
1984年 | 66篇 |
1983年 | 74篇 |
1981年 | 42篇 |
1979年 | 61篇 |
1978年 | 39篇 |
1973年 | 49篇 |
1972年 | 47篇 |
1971年 | 49篇 |
1968年 | 38篇 |
1933年 | 41篇 |
1923年 | 44篇 |
1913年 | 42篇 |
排序方式: 共有7593条查询结果,搜索用时 31 毫秒
31.
S Rivera C Gaugler C Langlet F Villega D Astruc B Escande P Kuhn J Messer 《Archives de pédiatrie》2004,11(11):1346-1350
Primary deficiency of surfactant is responsible for the respiratory distress syndrome and concerns premature neonates born before 33 weeks of gestation. However, newborns may develop respiratory disorders related to a secondary deficiency or dysfunction of surfactant. We report the course of three extremely low birth weight premature infants who experienced clinical respiratory decompensation at two weeks and showed a marked improvement after exogenous natural surfactant administration. 相似文献
32.
33.
E Walther R Hünig F Harder U Laffer A C Almendral H Dieterich J P Obrecht J Torhorst J Roth 《Helvetica chirurgica acta》1992,59(1):175-179
353 patients with stages pTis, pT1-2, pN0-1, cM0 breast cancer have been treated consecutively by breast conserving therapy in a prospective, nonrandomized study at the University Hospital Basel and the Women's Clinic Rheinfelden/Baden/Germany. The median age was 47 years, the median follow-up time 67 months, and 4% only of this collective were lost to follow-up after a median time of 42 months. In 79% of the cases the tumor was excised totally, while in 19% the resection margins were positive and in 2% only the margins were not available for histological judgement. The rate of local failure reached 8% with a median time interval of 53 months. 116 patients showed postactinic induration in the primary tumor region. 73 of these were given additional diagnostic examination: The postactinic induration was judget clinically suspicious in 51 cases and clinically nonsuspicious of local failure in 22 cases. All 73 patients received additional examination by mammography and biopsy. By comparison with the histological results the clinical results were correct in 59% and false in 41%, while the mammographic results were correct in 82% and false in 18% of the cases. 相似文献
34.
Th. Büttner S. Schulz W. Kuhn A. Blumenschein H. Przuntek 《European journal of neurology》1994,1(2):153-157
Colour discrimination and visual contrast perception were investigated in 18 patients with Huntington's disease (HD) and in 18 age- and sex-matched healthy volunteers using the Farnsworth-Munsell 100 Hue test (FM) and stationary contrast targets. The mean total error score (MTES) and the partial scores for the “red-green” and the “blue-yellow” axes in the FM of the patients with HD were significantly elevated as compared to controls (MTES in HD: 113.0 ± 90.8; MTES in controls: 19.2 ± 8.8). The spatial contrast sensitivity in HD patients was normal. The colour perception dysfunction indicates that the visual system is affected in HD. The visual disorder may be related to an imbalance of certain neurotransmitters in the visual system of HD patients. Possible anatomical sites of the dysfunction responsible for colour discrimination abnormalities could be the retinal cone system and/or impaired parvocellular central visual pathways in HD. 相似文献
35.
G J Jaffe T C Burton E Kuhn A Prescott A Hartz 《American journal of ophthalmology》1992,114(4):448-456
Twenty-one patients with symmetric nonproliferative retinopathy who underwent extracapsular cataract extraction and intraocular lens implantation were followed up postoperatively for an average (+/- standard deviation) of 18 +/- 7 months to determine the incidence of progression of diabetic retinopathy, the final visual acuity, and factors predictive of progression of retinopathy and final visual acuity. Progression of retinopathy, defined as the development of clinically significant macular edema, an increase in intraretinal hemorrhages or hard exudate, or the development of proliferative diabetic retinopathy, was assessed in both eyes of 19 patients; in two remaining patients, dense preoperative cataract in the fellow eye precluded comparison of retinopathy progression in the operated-on eye to progression in the fellow eye. Overall, retinopathy progressed in 14 of 19 operated-on eyes (74%). Cataract extraction was highly associated with asymmetric progression of nonproliferative retinopathy; it progressed only in the operated-on eye in seven of 19 patients (37%), but in no patients did progression occur in the fellow eye alone (P = .0078). Women had a significantly increased risk of progression of retinopathy in the operated-on eye compared to men (P = .005). Visual acuity improved in 19 of 21 operated-on eyes (86%); however, only 11 eyes (52%) achieved a visual acuity of 20/50 or better and only six eyes (14%) achieved a visual acuity of 20/25 or better. In only five eyes was the final visual acuity in the operated-on eye more than two lines better than the final visual acuity in the fellow eye.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
36.
Stefanie Klaffke Andrea A Kuhn Michail Plotkin Holger Amthauer Daniel Harnack Roland Felix Andreas Kupsch 《Movement disorders》2006,21(10):1724-1727
Alterations in presynaptic and postsynaptic dopaminergic system and cerebral glucose metabolism in corticobasal degeneration (CBD) were assessed to evaluate the potential usefulness of different imaging methods for CBD. (123)I-FP-CIT/(123)I-beta-CIT SPECT and (123)I-IBZM SPECT as well as (18)F-FDG PET were performed in eight CBD patients. Decreased presynaptic dopamine transporter binding was found in all CBD patients while D2 receptor binding was reduced in only one patient. (18)F-FDG PET displayed a contralateral hypometabolism in cortical and subcortical areas in seven out of eight patients. Our results demonstrate that glucose metabolism and DAT are reduced, while D2 receptors may be frequently preserved in CBD. 相似文献
37.
Pyogenic infections of the central nervous system of dental origin are quite uncommon in industrialized countries. We report
six cases with intracerebral (n=4) and intraspinal (n=2) infections treated in our hospital. The microbial pathogen was successfully isolated in all patients. Fusobacterium nucleatum as well as Streptococcus species were found in three cases. Bacillus species were identified in two patients. Actinomyces was the etiologic agent in one case. All patients suffered from dental pathologies, so that after clinical and radiological
exclusion of other sources an oral focus was presumed. Therapeutic management consisted of an operative procedure in order
to obtain decompression, as well as evacuation of the pus on the one hand, followed by targeted antibiotics on the other.
Clinical improvement was achieved in all patients, with one patient lost to follow-up. On magnetic resonance tomography, the
inflammatory changes also disappeared in all cases. We recommend that oral infection with recurrent bacteraemia should always
be considered in the pathogenesis of the so-called “cryptic” intracerebral and intraspinal infections. 相似文献
38.
Dr. Joseph A. Kuhn MD Lawrence D. Wagman MD John A. Lorant MD Fredrick W. Grannis MD Mordecai Dunst MD William R. Dougherty MD Daniel I. Jacobs MD 《Annals of surgical oncology》1994,1(4):353-359
Background: A radical forequarter amputation with partial chest wall resection (one to four ribs) has been reported for benign and malignant
lesions involving the shoulder and chest wall region. Concerns about reconstruction and postoperative pulmonary function have
previously limited more extensive chest wall resections. The current report describes the first case in which a complete unilateral
anterior and posterior chest wall resection and pneumonectomy (hemithoracectomy) accompany a forequarter amputation. A novel
reconstructive technique used the full circumference of the forearm tissue with an intact ulna as a free osseomyocutaneous
flap.
Methods: In this case, a 21-year-old patient presented with an extensive recurrent desmoid tumor that involved the shoulder, brachial
plexus, subclavian vein, and chest wall from the lateral sternal border to the midportion of the scapula and down to the eighth
rib. The operative technique involved removal of the entire right hemithorax from the midline sternum to the transverse process
posteriorly, down to the ninth rib inferiorly. Due to the absence of a rigid hemithorax, the uninvolved ipsilateral lung was
also removed. The forearm flap was prepared before final separation of the specimen and division of the subclavian vessels.
Results: Postoperatively, the patient maintained excellent oxygenation without atelectasis or fever and was extubated on the 15th
postoperative day. As expected after pneumonectomy, significant decreases from preoperative to immediate postoperative values
were noted for the vital capacity (VC) (from 4.87 L to 1.29 L), forced 1-s expiratory volume (FEV1) (from 3.77 L to 1.02 L),
and inspiratory capacity (IC) (3.33 1 to 0.99 1). Rehabilitation included a specially designed external prosthesis to provide
cosmesis and prevent scoliosis. By the 15th postoperative week the patient had returned to normal social and physical activities,
with a gradual improvement in all respiratory parameters: VC 1.52 L, FEV1 1.29 L, IC 1.04 L. There has been no evidence of
tumor recurrence at 1 year.
Conclusions: This report provides evidence that a complete hemithoracectomy, pneumonectomy, and forequarter amputation can be safely performed
for selective tumors involving the shoulder region with extensive chest wall invasion. Reconstruction may be achieved with
an extended forearm osseomyocutaneous free flap with an excellent functional outcome.
Presented at the 46th Annual Cancer Symposium of The Society of Surgical Oncology, Los Angeles, California, March 18–21, 1993. 相似文献
39.
T Schnabel N Zamboglou F P Kuhn C Kolotas G Schmitt 《Strahlentherapie und Onkologie》1992,168(10):584-587
Palliative treatment of recurrent rectal cancer remains to be a challenge. From 1989 to 1991 13 patients with recurrent rectal cancer were treated with intraarterial infusion of 5-Fluorouracil and simultaneous radiotherapy in a palliative intent. Seven patients had received postoperative adjuvant radiotherapy with 56 to 60 Gy. Three patients had been treated with systemic chemotherapy. Radiotherapy of the recurrence was performed with 19.8 to 30.6 Gy in the pre-irradiated patients and with 50.4 to 59.4 Gy in the others. One complete remission, three partial remissions and nine minor responses were observed. Three patients had complete pain relief after the treatment, in the remaining patients major pain reduction was achieved. Palliation lasted from three to twelve months (median: five months). Our results indicate that locoregional chemo- and radiotherapy are a effective modality in recurrent rectal cancer. 相似文献
40.
Elisabeth M Weiss Edith Stadelmann Christian G Kohler Colleen M Brensinger Karen A Nolan Herbert Oberacher Walther Parson Florian Pitterl Harald Niederst?tter Georg Kemmler Hartmann Hinterhuber Josef Marksteiner 《Journal of the International Neuropsychological Society》2007,13(5):881-887
The catechol-O-methyltransferase (COMT) Val158Met polymorphism modulates executive functions and working memory and recent neuroimaging studies implicate an association with emotional processing. We examined the relationship between the COMT Val158Met polymorphism and facial emotion recognition and differentiation in 100 healthy individuals. Compared to Met homozygosity, Val homozygosity was associated with better and faster recognition of negative facial expressions such as anger and sad. Our study provides evidence for a possible influence of the COMT polymorphism on emotion recognition abilities in healthy subjects. Additional research is needed to further define the neurocognitive phenotypes associated with COMT polymorphisms. 相似文献