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Integration of physical, breakpoint and genetic maps of chromosome 22. Localization of 587 yeast artificial chromosomes with 238 mapped markers 总被引:5,自引:0,他引:5
J.Bell Callum; L.Budarf Marcia; W.Nieuwenhuijsen Bart; L.Barnoski Barry; H.Buetow Kenneth; Campbell Keely; M.E.Colbert Angela; Collins Joelle; Daly Mark; R.Desjardins Philippe; DeZwaan Todd; Eckman Barbara; Foote Simon; Hart Kyle; Hiester Kevin; Hoog Marius J.Van Het; Hopper Elizabeth; Kaufman Alan; E.McDermid Heather; Overton G.Christian; Reeve Mary Pat; B.Searls David; Stein Lincoln; H.Valmiki Vinay; Watson Edward; Williams Sloan; Winston Rachel; Nussbaum Robert L.; S.Lander Eric; H.Fischbeck Kenneth; S.Emanuel Beverly; J.Hudson Thomas 《Human molecular genetics》1995,4(1):59-69
Detailed physical maps of the human genome are important resourcesfor the Identification and isolation of disease genes and forstudying the structure and function of the genome. We used datafrom STS content mapping of YACs and natural and induced chromosomalbreakpoints to anchor contigs of overlapping yeast artificialchromosome (YAC) clones spanning extensive regions of humanchromosome 22. The STSs were assigned to specific regions (bins)on the chromosome using cell lines from a somatic hybrid mappingpanel defining a maximum of 25 intervals. YAC libraries werescreened by PCR amplification of hierarchical pools of yeastDNA with 238 markers, and a total of 587 YAC clones were identified.These YACs were assembled into contigs based upon their sharedSTS content using a simulated annealing algorithm. Fifteen contigs,containing between 2 and 74 STSs were assembled, and orderedalong the chromosome based upon the cytogenetic breakpoint,meiotic and PFG maps. Additional singleton YACs were assignedto unique chromosomal bins. These ordered YAC contigs will beuseful for identifying disease genes and chromosomal breakpointsby positional cloning and will provide the foundation for higherresolution physical maps for large scale sequencing of the chromosome. 相似文献
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Mohammad A. Kaisar Ravi K. Sajja Shikha Prasad Vinay V. Abhyankar Taylor Liles 《Expert opinion on drug discovery》2017,12(1):89-103
Introduction: The blood-brain barrier (BBB) is a dynamic biological interface which actively controls the passage of substances between the blood and the central nervous system (CNS). From a biological and functional standpoint, the BBB plays a crucial role in maintaining brain homeostasis inasmuch that deterioration of BBB functions are prodromal to many CNS disorders. Conversely, the BBB hinders the delivery of drugs targeting the brain to treat a variety of neurological diseases.Area covered: This article reviews recent technological improvements and innovation in the field of BBB modeling including static and dynamic cell-based platforms, microfluidic systems and the use of stem cells and 3D printing technologies. Additionally, the authors laid out a roadmap for the integration of microfluidics and stem cell biology as a holistic approach for the development of novel in vitro BBB platforms.Expert opinion: Development of effective CNS drugs has been hindered by the lack of reliable strategies to mimic the BBB and cerebrovascular impairments in vitro. Technological advancements in BBB modeling have fostered the development of highly integrative and quasi- physiological in vitro platforms to support the process of drug discovery. These advanced in vitro tools are likely to further current understanding of the cerebrovascular modulatory mechanisms. 相似文献
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Kocher Thomas Holtfreter Birte Pitchika Vinay Kuhr Kathrin Jordan Rainer A. 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2021,64(7):782-792
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz - Zur Veränderung der oralen Krankheitslast in der deutschen Allgemeinbevölkerung über die letzten 20 Jahre... 相似文献
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Samrin Shaikh Varsha Shriram Amrita Srivastav Pranoti Barve Vinay Kumar 《Asian Pacific journal of tropical medicine》2018,(7)
Rumex nepalensis Spreng.(Polygonaceae) commonly known as Nepal Dock has wide-spectrum therapeutic potencies and is extensively used for centuries in traditional medicine systems. The leaves of this plant are edible and a rich source of natural antioxidants. They act as a possible food supplement and are largely used in pharmaceutical industry. Extracts and metabolites from this plant exhibits pharmacological activities including anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral, insecticidal, purgative, analgesic, antipyretic, anti-algal, central nervous system depressant, genotoxic, wound healing and skeletal muscle relaxant activity. Due to its remarkable biological activities, it has the potential to act as a rich source of drug against life threatening diseases. However, more studies are needed to scientifically validate the traditional uses of this plant, beside isolating and identifying their active principles and characterizing the mechanisms of action. We present herein a critical account of its botany, ecology, traditional uses, phytoconstituent profile and major pharmacological activities reported in recent years and therefore will provide a source of information on this plant for further studies. 相似文献
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Sajid S. Qureshi MS DNB FICS FAIS Seema Kembhavi MD Monica Bhagat MS DNB Siddharth Laskar MD Girish Chinnaswamy MD Tushar Vora MD Maya Prasad MD Mukta Ramadwar MD FRC Path Saral Desai MD Nehal Khanna MD Purna Kurkure MD Sneha Shah MD Vinay Shankdhar MS Mch Prabha Yadav MS Mch 《Journal of surgical oncology》2014,110(6):689-695
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