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101.
Sarita Silveira Verena Graupmann Maria Agthe Evgeny Gutyrchik Janusch Blautzik Idil Demir?apa Andrea Berndt Ernst P?ppel Dieter Frey Maximilian Reiser Kristina Hennig-Fast 《Social cognitive and affective neuroscience》2014,9(10):1601-1607
Being reminded of the inherently finite nature of human existence has been demonstrated to elicit strivings for sexual reproduction and the formation and maintenance of intimate relationships. Recently, it has been proposed that the perception of potential mating partners is influenced by mortality salience. Using functional magnetic resonance imaging, we investigated the neurocognitive processing of attractive opposite-sex faces after priming with death-related words for heterosexual men and women. Significant modulations of behavioral and neural responses were found when participants were requested to decide whether they would like to meet the presented person. Men were more in favor of meeting attractive women after being primed with death-related words compared to a no-prime condition. Increased neural activation could be found under mortality salience in the left anterior insula and the adjacent lateral prefrontal cortex (lPFC) for both men and women. As previously suggested, we believe that the lPFC activation reflects an approach-motivated defense mechanism to overcome concerns that are induced by being reminded of death and dying. Our results provide insight on a neurocognitive level that approach motivation in general, and mating motivation in particular is modulated by mortality salience. 相似文献
102.
Dr Kevin Fitzgerald Maria Frank-Kamenetsky Svetlana Shulga-Morskaya Abigail Liebow Brian R Bettencourt Jessica E Sutherland Renta M Hutabarat Valerie A Clausen Verena Karsten Jeffrey Cehelsky Saraswathy V Nochur Victor Kotelianski Jay Horton Timothy Mant Joseph Chiesa James Ritter Malathy Munisamy Akshay K Vaishnaw Jared A Gollob Amy Simon 《Lancet》2014
103.
Mahalakshmi Subramaniam Beatrice Kern Simone Vogel Verena Klose Gaby Schneider Jochen Roeper 《The European journal of neuroscience》2014,40(6):2898-2909
The impairment of protein degradation via the ubiquitin‐proteasome system (UPS) is present in sporadic Parkinson's disease (PD), and might play a key role in selective degeneration of vulnerable dopamine (DA) neurons in the substantia nigra pars compacta (SN). Further evidence for a causal role of dysfunctional UPS in familial PD comes from mutations in parkin, which results in a loss of function of an E3‐ubiquitin‐ligase. In a mouse model, genetic inactivation of an essential component of the 26S proteasome lead to widespread neuronal degeneration including DA midbrain neurons and the formation of alpha‐synuclein‐positive inclusion bodies, another hallmark of PD. Studies using pharmacological UPS inhibition in vivo had more mixed results, varying from extensive degeneration to no loss of DA SN neurons. However, it is currently unknown whether UPS impairment will affect the neurophysiological functions of DA midbrain neurons. To answer this question, we infused a selective proteasome inhibitor into the ventral midbrain in vivo and recorded single DA midbrain neurons 2 weeks after the proteasome challenge. We found a selective increase in the mean in vivo firing frequencies of identified DA SN neurons in anesthetized mice, while those in the ventral tegmental area (VTA) were unaffected. Our results demonstrate that a single‐hit UPS inhibition is sufficient to induce a stable and selective hyperexcitability phenotype in surviving DA SN neurons in vivo. This might imply that UPS dysfunction sensitizes DA SN neurons by enhancing ‘stressful pacemaking’. 相似文献
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Annika Eickhoff Jonas Tjaden Sarah Stahlke Matthias Vorgerd Verena Theis Veronika Matschke Carsten Theiss 《中国神经再生研究》2022,(11):2465-2471
Plasticity of cerebellar Purkinje cells (PC) is influenced by progesterone via the classical progesterone receptors PR-A and PR-B by stimulating dendritogenesis... 相似文献
107.
Verena Niggli Arthur Zimmermann Hansuli Keller 《International journal of cancer. Journal international du cancer》1996,65(4):473-478
Signal transduction pathways controlling tumor cell locomotion are not yet well understood. We have studied the role of protein kinase C (PKC)-dependent protein phosphorylation associated with changes in cell shape and locomotor activity of Walker carcinosarcoma cells in culture. We show that the inhibitory effect of phorbol-12-myristate-13-acetate (PMA), an activator of PKC, on cell polarity and locomotion can be suppressed by the PKC-selective inhibitor Ro 31-8220. PMA induces increased phosphorylation of at least 2 proteins, of 65 and 80 kDa, in intact Walker carcinosarcoma cells. These bands are enriched in cytosolic fractions isolated from cells incubated with 32PO4. Pre-incubation with Ro 31-8220 inhibits the PMA-induced phosphorylation of both bands in a concentration-dependent manner. This effect is very likely not due to inhibition of translocation of PKC to the membrane as Ro 31-8220 enhances, rather than inhibits, PMA-induced transfer of PKC β11 to the particulate fraction. We have carried out a quantitative analysis of phosphorylation of the 80-kDa band. Ro 31-8220 reverses both PMA-induced phosphorylation of this band and PMA-induced suppression of cell polarity in parallel. Increased phosphorylation of proteins via PKC may thus be a stop signal for locomoting Walker carcinosarcoma cells. © 1996 Wiley-Liss, Inc. 相似文献
108.
Keser Tobias Kofler Mario Katzmayr Mariella Schiefecker Alois J. Rass Verena Ianosi Bogdan A. Lindner Anna Gaasch Maxime Beer Ronny Rhomberg Paul Schmutzhard Erich Pfausler Bettina Helbok Raimund 《Neurocritical care》2020,33(1):132-139
Neurocritical Care - Despite the tremendous impact of swallowing disorders on outcome following ischemic stroke, little is known about the incidence of dysphagia after subarachnoid hemorrhage (SAH)... 相似文献
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