全文获取类型
收费全文 | 1853篇 |
免费 | 97篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 88篇 |
妇产科学 | 21篇 |
基础医学 | 181篇 |
口腔科学 | 42篇 |
临床医学 | 118篇 |
内科学 | 373篇 |
皮肤病学 | 60篇 |
神经病学 | 102篇 |
特种医学 | 39篇 |
外科学 | 317篇 |
综合类 | 60篇 |
一般理论 | 11篇 |
预防医学 | 100篇 |
眼科学 | 124篇 |
药学 | 190篇 |
中国医学 | 8篇 |
肿瘤学 | 112篇 |
出版年
2023年 | 21篇 |
2022年 | 72篇 |
2021年 | 157篇 |
2020年 | 77篇 |
2019年 | 104篇 |
2018年 | 98篇 |
2017年 | 70篇 |
2016年 | 78篇 |
2015年 | 85篇 |
2014年 | 125篇 |
2013年 | 126篇 |
2012年 | 167篇 |
2011年 | 137篇 |
2010年 | 76篇 |
2009年 | 61篇 |
2008年 | 79篇 |
2007年 | 60篇 |
2006年 | 40篇 |
2005年 | 44篇 |
2004年 | 16篇 |
2003年 | 24篇 |
2002年 | 29篇 |
2001年 | 23篇 |
2000年 | 22篇 |
1999年 | 14篇 |
1998年 | 5篇 |
1997年 | 2篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1994年 | 4篇 |
1993年 | 4篇 |
1992年 | 15篇 |
1991年 | 15篇 |
1990年 | 19篇 |
1989年 | 10篇 |
1988年 | 12篇 |
1987年 | 3篇 |
1986年 | 3篇 |
1985年 | 5篇 |
1984年 | 4篇 |
1982年 | 2篇 |
1980年 | 4篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1977年 | 6篇 |
1976年 | 6篇 |
1975年 | 4篇 |
1972年 | 3篇 |
1966年 | 5篇 |
1965年 | 3篇 |
排序方式: 共有1957条查询结果,搜索用时 0 毫秒
101.
Rajalakshmi Poyuran Nandeesh bn Yerasi Varun Kumar Reddy Amey R. Savardekar 《Neuropathology》2017,37(4):346-350
Gliosarcoma, a variant of isocitrate dehydrogenase‐wildtype glioblastoma, is largely a lobar surfacing neoplasm often with dural attachment. In this biphasic neoplasm, the sarcomatous component usually takes the form of fibrosarcoma or malignant fibrous histiocytoma. Heterologous sarcomatous differentiation is a rare phenomenon. Here, we present a case of gliosarcoma with liposarcomatous and myosarcomatous differentiation in a 68‐year‐old man which was purely intraventricular. This is the first report of such a morphologic pattern in this location. Varied histological components with their immunohistochemical profile are discussed. Of note was the presence of a p53 negative giant cell glioblastoma component, as was the expression in the rest of the tumor. 相似文献
102.
Satyaswarup Tripathy Devi Prasad Mohapatra Ranjit Kumar Sahu Subair Mohsina Ramesh Kumar Sharma Subhendu Khan Sharda Renu Chandra Kunwari Singh Suraj R. Nair Shijina Koliath Imran Pathan 《Indian Journal of Plastic Surgery》2022,55(1):45
Introduction The study was carried out to quantify the changes induced by the pandemic in plastic surgery practice and training and to study the impact of the webinars on plastic surgery education from a residents’ perspective. Methods In this multicentric study, the number and type of surgeries, cause of injuries, and their regional variation during the coronavirus disease 2019 (COVID-19) period (February–September 2020) were compared with pre–COVID-19 time. An online survey on the impact of webinars was conducted for plastic surgery trainees across the country. Results There was a significant reduction in total number of surgeries ( p = 0.003). The procedures for hand ( p = 0.156), faciomaxillary injuries ( p = 0.25), and replantations ( p = 0.46) were comparable; there was a significant reduction in combined orthopedic-plastic-surgical procedures ( p = 0.009) during the pandemic. There was a significant reduction in road accidents ( p = 0.007) and suicidal injuries ( p = 0.002) and increase in assault ( p = 0.03) and domestic accidents ( p = 0.01) during the COVID-19 period. A usefulness score of >8 was given for the webinars by 68.7% residents. There was no significant difference in perception of utility when correlated with the academic program at their institutes ( p = 0.109); 92% opined webinars should continue in post-COVID times. Conclusion There was a drastic reduction in number of elective and emergency procedures during the COVID-19 time, negatively affecting resident training program. Majority of residents felt that webinars could prove a useful adjunct to training in formal training program in post-COVID-19 scenario. 相似文献
103.
The present study was undertaken to isolate a novel antidiabetic molecule from Swietenia macrophylla seeds. The hydroalcohol extract of Swietenia macrophylla seeds was subjected for bioassay guided isolation employing glucose utilization assay by the isolated rat hemi‐diaphragm method in vitro. One tetranortriterpenoid, swietenine, isolated from the chloroform fraction exhibited significant (p < 0.01) activity and the effect was comparable to that of human insulin (p < 0.01). Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
104.
A Sahu K Saha A Mukherjee V N Sehgal 《International journal of immunopharmacology》1992,14(4):721-730
The present study describes the in vivo effects of anti-leprosy drugs on rat peritoneal macrophages and T-cell homeostasis. It was observed that BCG-elicited rat peritoneal macrophages produced more H2O2 and expressed more Ia antigen on their cell surfaces compared with resident peritoneal macrophages. Furthermore, elicited macrophages isolated from rats administered multidrug therapy (MDT), consisting of dapsone, clofazimine and rifampicin in high dose (10 x MDT) released more O2-. On the contrary, there was a significant decrease in the Ia antigen expression on these macrophages. Anti-leprosy drug treatment in high dose (10 x MDT) decreased the total number of blood T-helper (W3/25+) cells and increased the total number of blood T-suppressor (OX-8+) cells which resulted in a significant decrease in a W3/25: OX-8 ratio. Electron microscopy of elicited macrophages isolated from 10 x MDT treated rats showed development of many filipodia compared with control macrophages. These data show that 10 x MDT treatment in rats for 1 month alters the homeostasis of blood T-cell subpopulations which perhaps decreases the Ia expression on macrophages. However, the increase in O2- production and the appearance of filipodia on the macrophages is due to a direct effect of drugs on the macrophages. MDT treatment for 1 month in a therapeutic dose has no effect on the above-mentioned parameters. 相似文献
105.
106.
107.
The most common cause of proximal radioulnar synostosis in adults is traumatic, usually after forearm fractures. Disabling complications are mainly loss of rotatory movements of the forearm. Various surgical procedures have been described in the literature to end up in forearm synostosis as a complication. We here presented a rare case of proximal forearm synostosis following a common but improper surgical technique for an olecranon fracture complicated by implant infection. The synostosis was treated by resection and fascia lata interposition graft. 相似文献
108.
Jajati K. Mohapatra Abhipsa Sahu Sushanta K. Barik Aniket Sanyal Bramhadev Pattnaik 《Virus genes》2009,39(1):81-89
India is endemic for foot-and-mouth disease (FMD) and in recent years a unique group within serotype A, carrying a codon deletion
at an antigenically critical site in capsid protein VP3 has emerged (VP359-deletion group). This tempted us to analyze the noncoding region, which is an under represented area, though critically associated
with virus biology and pathogenesis. Analysis of the large fragment of 5′ untranslated region (LF-5′ UTR) of type A FMD virus
revealed discrepancy in the overall tree topology between LF-5′ UTR and 1D region possibly due to independent evolution of
coding and noncoding regions. The VP359-deletion group maintained its phylogenetic distinctness even at the LF-5′ UTR. Eighteen lineage specific signatures detected
here support independent evolutionary paths for the lineages. Extensive deletions of 45 and 89 nucleotides corresponding to
the pseudoknot region were noticed. Conservation pattern in the ‘A253AACA’ motif in the cre/bus stem-loop indicates the importance of first three ‘A’ residues in VPg uridylylation. Of the three polypyrimidine tract binding
protein (PTB) binding sites mapped on the internal ribosome entry site (IRES), the pyrimidine tract (Py tract) in the loop
of domain 2 was found to be maximally conserved and it might be the major PTB binding site. Strikingly, a deletion group lineage
specific transversion was noticed in the Py tract at the 3′ end of IRES without significantly affecting its in vitro infectious
titer. Hence, we presume that for efficient cap-independent viral translation, either a minimum number of pyrimidine residues
rather than a complete Py tract or a Py tract tolerating transversions only at specific locations and a core motif ‘CUUU’
within the Py tract is essential. 相似文献
109.
Sahu Tapish Mustafa Taha Garg Naresh Dhamija Neeraj K. Malik Vinod 《The Indian journal of surgery》2010,72(1):306-308
Mucormycosis of the anterior abdominal wall is an uncommon disease and it is very rare to find this disease in immunocompetent, non-diabetic patients which usually affects patients with trauma, with contaminated wounds, patients with underlying malignancies or patients with immunocompromised state, e.g., diabetics. We herein report a case of primary cutaneous mucormycosis in an immunocompetent and non-diabetic patient. Our patient was a 48-year-old female, executive by profession. She was diagnosed to have cutaneous mucormycosis of the anterior abdominal wall, and was managed with multiple debridements of the wound and intravenous amphotericin B therapy. She was administered a total of 1500 mg of liposomal amphotericin B and when fully healed, split skin grafting was done. We would like to emphasize the importance of high index of suspicion and early start of therapy in a condition with high rate of mortality. 相似文献
110.
ObjectiveTo estimate the overall quality-adjusted life-years (QALYs) gained by averting 1 coronavirus disease 2019 (COVID-19) infection over the duration of the pandemic.MethodsA cohort-based probabilistic simulation model, informed by the latest epidemiological estimates on COVID-19 in the United States provided by the Centers for Disease Control and Prevention and literature review. Heterogeneity of parameter values across age group was accounted for. The main outcome studied was QALYs for the infected patient, patient’s family members, and the contagion effect of the infected patient over the duration of the pandemic.ResultsAverting a COVID-19 infection in a representative US resident will generate an additional 0.061 (0.016-0.129) QALYs (for the patient: 0.055, 95% confidence interval [CI] 0.014-0.115; for the patient’s family members: 0.006, 95% CI 0.002-0.015). Accounting for the contagion effect of this infection, and assuming that an effective vaccine will be available in 3 months, the total QALYs gains from averting 1 single infection is 1.51 (95% CI 0.28-4.37) accrued to patients and their family members affected by the index infection and its sequelae. These results were robust to most parameter values and were most influenced by effective reproduction number, probability of death outside the hospital, the time-varying hazard rates of hospitalization, and death in critical care.ConclusionOur findings suggest that the health benefits of averting 1 COVID-19 infection in the United States are substantial. Efforts to curb infections must weigh the costs against these benefits. 相似文献