经典型皮肤卡勃基氏肉瘤与放射治疗

经典型皮肤卡勃基氏肉瘤与放射治疗于顺江ＹＭＫｉｒｏｖａＪＰＬｅＢｏｕｒｇｅｏｉｓ１９８６年６月至１９９６年１２月，ＨＭｏｎｄｏｒ医院肿瘤科对６５０例卡勃基氏肉瘤患者进行了放疗，其中仅５例为经典型皮肤卡勃基氏肉瘤，现报告如下。５例患者：男２例，女３例，...     

Cross sectional study of use of alternative medicines in Chinese cancer patients

The aim of this study was to ascertain the prevalence of alternative medicine consumption in Chinese cancer patients on active conventional treatment. A cross sectional survey of 100 consecutive advanced cancer patients admitted to a cancer clinical trial referral unit were personally interviewed by their assigned oncology research nurse using a specially designed questionnaire. The results showed that 64% of our patients used indigenous Chinese medication. In all age groups except the over-70s (P = 0.043), > 50% took such medication, more female (76%) than male (57.6%) patients (P = 0.323). Patients of all educational levels (P = 0.062) and religious backgrounds (P = 0.08) consumed alternative medicines. Duration of alternative medication consumption was less than three months in 50% of patients, with costs between US$40 and 2000/month for 70% of patients. Reasons cited for alternative medication consumption was hope that it might be of some benefit to their well being or disease control, and maybe even result in a miracle cure. Sources of advice on medication were mostly from strangers (by word of mouth), family, friends, the media, and infrequently from qualified professional Chinese doctors. Reasons for discontinuing such treatment were mostly given as lack of positive effect. In conclusion, Chinese cancer patients, willingly, rampantly and non-selectively seek out and consume alternative medications, with almost total ignorance of the medication consumed, oblivious to any potential side effects, and with little subjective benefit.      

QUO VADIS:奎那普利对血管ACE和缺血的影响(摘要)

疾病 冠心病。目的 通过运动试验、24小时动态ECG以及临床缺血事件了解奎那普利治疗1年后对CABG病人缺血的影响。     

纳米羟基磷灰石沉积层/钛酸钾薄层/钛合金生物复合材料体外培养成骨细胞的研究

在制备出具有表面活性的纳米羟基磷灰石沉积层/钛酸钾薄层/钛合金（HA/K2Ti6O13/β-Ti）生物复合材料的基础上,将体外培养的成骨细胞与HA/K2Ti6O13/β-Ti生物复合材料、未经处理β钛合金两种骨替代材料共同培养,在既定时间内观察两种骨替代材料对成骨细胞生长、附着的影响。结果表明两种骨替代材料对成骨细胞生长无明显抑制或促进作用,均具有良好的细胞相容性,它们皆能使成骨细胞附着于各自材料表面,分泌形成胶原纤维样基质。HA/K2Ti6O13/β-Ti生物复合材料较β钛合金具有更优异的的生物活性和成骨性能,是一种很好的生物植入材料。     

1-(α-萘甲基)-2甲基-6,7-二甲氧基-1,2,3,4-四氢异喹啉盐酸盐的HPLC手性拆分法及半制备

1-(α-Naphthylmethy)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolinehydrochloride (code No, 86040)is a new kind of calcium antagonist. It has(+)and(一)enantiomers.Accordingly .the resolution and quantification of these two enantiomers have received agreat deal of attention,In this report the application of direct HPLC separation and semipreparation tothe determination of the enantiomeric composition of the new drug are described. All analysis andsemipreparation were performed with 25 cm×4. 6 mm i.d, 25 cm×8 mm i,d.and 30 cm×8 mmi.d. stainless steel column packed with a chiral β-cycledextrin bonded phase. Detection wavelengthwas 284 nm, The optimal composition of the mobile phase was EtOH─pH 4.0 phosphate buffer(35:65) at flow rate of 0. 3 ml·min^-1 for analysis and l.0 ml·min^-1 for semipreparation. Theseparation factor of the enantiomers was l.25. Purity of the semipreparation was 8l.4%,Quantityof semipreparation was 1 mg. This procedure was simple ,rapid and gave good resolution,The effectsof the composition of mobile phase, pH value, flow rate and column temperature on the resolution hadbeen sudied.     

贲门失弛缓症术后并发食管旁疝致胃底绞窄坏死1例

介绍1例贲门失弛缓症Heller术后16 a并发食管旁疝致胃底绞窄坏死的病例．报告本例患者的详细病历资料和诊治经过．患者起病5 d后剖胸探查,发现胃底疝入左侧胸腔并绞窄坏死,行近端胃大部切除,修复食管裂孔．术后随访1 a无复发．食管旁疝发生嵌顿时,应立即插入胃管减压．如减压不成功或症状不改善,应急诊手术探查．