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61.
62.
Thomas W. McGovern M.D. CPT MC USA Scott D. Bennion M.D. COL MC USA 《Pediatric dermatology》1994,11(4):319-322
Abstract: Dermatitis herpetiformis (DH) is seen most commonly as a pruritic, papulovesicular eruption in young children or adolescents. Differentiation from other bullous diseases of childhood may be difficult. We report the first case of an adolescent in whom pruritic, palmar, purpuric macules and papules were the only manifestations of DH. The patient later developed typical vesiculobullous extensor lesions and symptomatic gluten-sensitive enteropathy (GSE). All lesions and GSE symptoms resolved with dapsone and a gluten-free diet. Our purpose is to illustrate an unusual presentation of pediatric DH. 相似文献
63.
乙型肝炎病毒(HBV)所致的肝细胞坏死,被认为是与人类白细胞抗原(HLA)有关的MHC限制的T细胞为主的免疫应答的结果。本研究证实,转染HBV基因组或X基因后的人肝癌细胞系可诱导HLAⅡ(即HLA DR)表达。核转录及RNA杂交分析提示表达X基因的细胞其HLA DR mRNA水平增加,X蛋白增加该基因的转录。氯霉索乙酰基转移酶(CAT)基因分析进一步提示,X蛋白通过作用于HLA DR基因上游的调节序列诱导HLA DR表达。结果表明:X蛋白可能通过调节HLA DR表达参与HBV感染的免疫发病机理。 相似文献
64.
Dr. Wang
Zhengguo member of the editorial board of the Chinese Medical Journal a noted military
surgeon of the Research Institute of Surgery the Third Military Medical University Chongqing China received the Michael E. DeBakey International Military Surgeons
Award on March in Bethesda Maryland USA in recognition of his many years of
dedicated valuable efforts in supporting the worldwide activities to improve military
medicine surgery. 《中华医学杂志(英文版)》1998,111(10):955
Dr. Wang Zhengguo, member of the editorial board of the Chinese Medical Journal, a noted military surgeon of the Research Institute of Surgery, the Third Military Medical University, Chongqing, China, received 1998 the Michael E. DeBakey International Military Surgeons Award on March 23, 1998 in Bethesda, Maryland, USA, in recognition of his many years of dedicated and valuable efforts in supporting the worldwide activities to improve military medicine and surgery. 相似文献
65.
66.
MAJ MD USA MCMartin J. Gillespie CPT MD USA MCJohn Friedland MDKenneth E. Dehaven 《Operative Techniques in Sports Medicine》1998,6(2):102-110
This article provides a complete review of arthrofibrosis following ACL reconstruction, and a complete review of theetiology, classification, and histology of arthrofibrosis. A clinician's guide to the recognition of arthrofibrosis and when the arthrofibrosis is clinically significant, treatment of arthrofibrosis after determination of arthrofibrosis, and its treatment to include surgical and nonsurgical management is noted. We emphasize prevention with appropriate indications and timing of ACL reconstruction and appropriate intraoperative surgical techniques for a correctly performed ACL reconstruction. The appropriate rehabilitation and expected clinical progress and parameters to follow after ACL reconstruction with emphasis on early recognition and early treatment will significantly improve the outcome of treatment of clinically significant arthrofibrosis and hopeful prevention of arthrofibrosis. By applying the techniques reviewed, prevention of arthrofibrosis is the orthopaedic surgeons best weapon. 相似文献
67.
AIM:To isolate and characterize solid tumor inhibitory and other constituents from a bioactive extract of Casimiroa tetrameria((Rutaceae).METHODS:A crude extract of C.tetrameria obtained from the US National Cancer Institute Natural Product Repository and found to exhibit selective toxicity to solid tumor cells was subjected bioactivity-guided fractionation involving solvent-solvent partitioning,gel filtration,and chromatography.The structures of all isolated compounds were elucidated by spectroscopic analy... 相似文献
68.
张军 《中医杂志(英文版)》2010,(1)
Introduction Autism is a complex developmental disability that typically appears during the first two years of man's life and is the result of a neurological disorder that affects the functioning of the brain,and the 相似文献
69.
LOS诱导的特异性抗体分泌细胞的ELISPOT法检测 总被引:3,自引:1,他引:3
目的 :动态测定卡他性莫拉氏菌 (Moraxellacatarrhalis,M .cat)脱毒脂寡糖 (dLOS)蛋白质结合疫苗诱导的抗体分泌细胞的应答状态。方法 :以M .catdLOS蛋白质结合疫苗滴鼻免疫BALB/c小鼠。应用酶联免疫斑点试验 (ELISPOT)检测免疫小鼠不同免疫诱导部位和免疫效应部位 ,包括 :鼻相关淋巴组织 (NALT)、脾脏、颈部淋巴结、鼻内容物、肺脏和派伊尔氏结的特异性抗体分泌细胞 ,并同时测定血清、鼻冲洗液、肺泡灌洗液、唾液及粪便提取液中特异性IgA、IgG和IgM的水平。结果 :M .catdLOS蛋白质结合疫苗免疫小鼠的NALT、脾脏、颈部淋巴结、鼻内容物、肺脏和派伊尔氏结中 ,均测出分泌LOS特异抗体的抗体分泌细胞 ,以鼻内容物中IgA分泌细胞的数目最多 ,其次是在NALT和肺脏中 ,这与特异性抗体测定的结果相一致。结论 :M .catdLOS蛋白质结合疫苗经滴鼻免疫 ,能刺激产生LOS特异的黏膜和全身抗体分泌细胞的应答。ELISPOT试验具有快速、灵敏、特异的优点 ,为动态分析单个抗体分泌细胞应答规律提供了新方法。 相似文献
70.
Co‐occurring medical conditions in adults with Down syndrome: A systematic review toward the development of health care guidelines 下载免费PDF全文
George T. Capone Brian Chicoine Peter Bulova Mary Stephens Sarah Hart Blythe Crissman Andrea Videlefsky Katherine Myers Nancy Roizen Anna Esbensen Moya Peterson Stephanie Santoro Jason Woodward Barry Martin David Smith for the Down Syndrome Medical Interest Group DSMIG‐USA Adult Health Care Workgroup 《American journal of medical genetics. Part A》2018,176(1):116-133
Adults with Down syndrome (DS) represent a unique population who are in need of clinical guidelines to address their medical care. The United States Preventive Service Task Force (USPSTF) has developed criteria for prioritizing conditions of public health importance with the potential for providing screening recommendations to improve clinical care. The quality of existing evidence needed to inform clinical guidelines has not been previously reviewed. Using the National Library of Medicine (NLM) database PubMed, we first identified 18 peer reviewed articles that addressed co‐occurring medical conditions in adults with DS. Those conditions discussed in over half of the articles were prioritized for further review. Second, we performed detailed literature searches on these specific conditions. To inform the search strategy and review process a series of key questions were formulated a priori. The quality of available evidence was then graded and knowledge gaps were identified. The number of participating adults and the design of clinical studies varied by condition and were often inadequate for answering all of our key questions. We provide data on thyroid disease, cervical spine disease, hearing impairment, overweight‐obesity, sleep apnea, congenital heart disease, and osteopenia‐osteoporosis. Minimal evidence demonstrates massive gaps in our clinical knowledge that compromises clinical decision‐making and management of these medically complex individuals. The development of evidence‐based clinical guidance will require an expanded clinical knowledge‐base in order to move forward. 相似文献