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91.
Chung-Jen Lee Yi-Jen Hsieh Yu-Li Lin Chih-Hsien Wang Bang-Gee Hsu Jen-Pi Tsai 《Nutrients》2022,14(12)
Vitamin D deficiency and high brachial-ankle pulse wave velocity (baPWV) are each independently associated with higher incidence of mortality and cardiovascular (CV) disease or CV events, respectively. This study aimed to evaluate the relationship between serum 25-hydroxyvitamin D levels and baPWV in non-dialysis patients with stage 3–5 chronic kidney disease (CKD). We enrolled 180 CKD patients. A commercial enzyme-linked immunosorbent assay was used to measure 25-hydroxyvitamin D levels. BaPWV values were measured using an automatic pulse wave analyzer. Either left or right baPWV > 18.0 m/s was considered indicative of peripheral arterial stiffness (PAS). In this study, 73 (40.6%) patients were found to have PAS. Compared to those without PAS (control group), patients with PAS were older and had higher incidence of diabetes mellitus, higher systolic and diastolic blood pressure, higher levels of intact parathyroid hormone, and C-reactive protein, and lower levels of 25-hydroxyvitamin D. Multivariate logistic regression analysis found 25-hydroxyvitamin D levels (odds ratio [OR]: 0.895, 95% confidence interval [CI] 0.828–0.968, p = 0.005) and old age (OR: 1.140, 95% CI 1.088–1.194, p < 0.001) to be independently associated with PAS in patients with stage 3–5 CKD. Lower serum 25-hydroxyvitamin D levels and older age were associated with PAS in these patients. 相似文献
92.
Yu-Jyuan Wang Pei-Ying Lin Shu-Ling Hsieh Rajendranath Kirankumar Hsin-Yi Lin Jia-Huei Li Ya-Ting Chen Hao-Ming Wu Shuchen Hsieh 《Materials》2021,14(8)
The purpose of this study was to use agar as a multifunctional encapsulating material to allow drug and ferromagnetism to be jointly delivered in one nanoparticle. We successfully encapsulated both Fe3O4 and doxorubicin (DOX) with agar as the drug carrier to obtain DOX-Fe3O4@agar. The iron oxide nanoparticles encapsulated in the carrier maintained good saturation of magnetization (41.9 emu/g) and had superparamagnetism. The heating capacity test showed that the specific absorption rate (SAR) value was 18.9 ± 0.5 W/g, indicating that the ferromagnetic nanoparticles encapsulated in the gel still maintained good heating capacity. Moreover, the magnetocaloric temperature could reach 43 °C in a short period of five minutes. In addition, DOX-Fe3O4@agar reached a maximum release rate of 85% ± 3% in 56 min under a neutral pH 7.0 to simulate the intestinal environment. We found using fluorescent microscopy that DOX entered HT-29 human colon cancer cells and reduced cell viability by 66%. When hyperthermia was induced with an auxiliary external magnetic field, cancer cells could be further killed, with a viability of only 15.4%. These results show that agar is an efficient multiple-drug carrier, and allows controlled drug release. Thus, this synergic treatment has potential application value for biopharmaceutical carrier materials. 相似文献
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Pagona Lagiou Chung-Cheng Hsieh Evangelia Samoli Areti Lagiou Biao Xu Guo-Pei Yu Sagano Onoyama Lucy Chie Lars J. Vatten Hans-Olov Adami Dimitrios Trichopoulos Michelle A. Williams 《Annals of epidemiology》2013,23(11):669-673
PurposePlacental weight has been associated with mammographic pattern and coronary heart disease in the adult offspring, but the mechanisms are unknown. We evaluated the associations of maternal and cord blood hormones with placental weight in normal pregnancies.MethodsProspective study of 167 normal singleton pregnancies in Boston, USA and 256 in Shanghai, China. Maternal hormone levels at the 27th gestational week were available for all pregnancies. Cord blood measurements were available for 86 pregnancies in Boston and 104 in Shanghai. Pearson partial correlation coefficients of log-transformed hormone levels with placental weight were calculated.ResultsMaternal levels of estriol, testosterone, and progesterone (P < .05) were positively associated with placental weight. There was no such evidence for adiponectin, prolactin, and insulin-like growth factor (IGF)-I. Cord blood steroids tended to be inversely associated with placental weight, the results being statistically significant for testosterone (P < .05). There was a marginally significant positive association of cord blood IGF-I with placental weight. Reported results were adjusted for study center.ConclusionsPlacental weight appears to be positively correlated with maternal steroids. Its correlation with cord blood steroids, however, appears inverse, compatible with negative feedback mechanisms. There is also a suggestion for placental weight to be positively associated with cord blood IGF-I. 相似文献
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Role of melatonin receptor 1A and pituitary homeobox‐1 coexpression in protecting tubular epithelial cells in membranous nephropathy 下载免费PDF全文
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T. H. Hsieh C. P. Yu 《Inhalation toxicology》2013,25(2):121-130
Existing experimental data on pulmonary clearance of low-toxicity, poorly soluble particles in several mammalian species including the rat, mouse, guinea pig, dog, monkey, and human have been analyzed using a two-exponential time-decay function with one exponential representing the fast clearance phase and the other for the slow clearance phase. Mass fractions of both clearance phases and the corresponding clearance rates were determined from the lung burden data for different specific initial lung burdens (initial lung burden/ lung weight). It was found that the slow clearance mass fraction increased with lung burden for all species, and it approached almost 100% when the specific initial lung burden exceeded 1 mg/ g lung. However, the slow clearance mass fraction at low lung burdens was found to be much higher for the slow-clearing species (guinea pig, dog, monkey, and human) than for the fast-clearing species (rat and mouse). It was also found that the fast clearance rate was nearly a constant, but the slow clearance rate decreased with lung burden. In addition, both clearance rates differed slightly between the fast-clearing and slow-clearing species. Based upon these data, a formula is proposed to calculate the clearance rate at any lung burden for humans. 相似文献
100.
Po-Hsiang Liao Dennis Jine-Yuan Hsieh Chia-Hua Kuo Cecilia-Hsuan Day Chia-Yao Shen Chao-Hung Lai Ray-Jade Chen V. Vijaya Padma Wei-Wen Kuo Chih-Yang Huang 《Oncotarget》2015,6(34):35383-35394
Aging is the most important risk factor in cardiovascular disease (CVD), which is the leading causes of death worldwide and the second major cause of death in Taiwan. The major factor in heart failure during aging is heart remodeling, including long-term stress-induced cardiac hypertrophy and fibrosis. Exercise is good for aging heart health, but the impact of exercise training on aging is not defined. This study used 3-, 12- and 18-month-old rats and randomly divided each age group into no exercise training control groups (C3, A12 and A18) and moderate gentle swimming exercise training groups (E3, AE12 and AE18). The protocol of exercise training was swimming five times weekly with gradual increases from the first week from 20 to 60 min for 12 weeks. Analyses of protein from rat heart tissues and sections revealed cardiac inflammation, hypertrophy and fibrosis pathway increases in aged rat groups (A12 and A18), which were improved in exercise training groups (AE12 and AE18). There were no heart injuries in young rat hearts in exercise group E3. These data suggest that moderate swimming exercise training attenuated aging-induced cardiac inflammation, hypertrophy and fibrosis injuries of rat hearts. 相似文献