Acetabular development in developmental dysplasia of the hip. A radiographic study in anatomically reduced and uncomplicated hips

The objective of this prospective, controlled study was to assess the radiographic course of acetabular develop- ment in developmental dysplasia of the hip (DDH). The study consisted of 14 patients (mean age at operation, 12 months; range, 6 to 18 months) from a large, prospective series diagnosed with unilateral DDH and treated by a soft tissue surgical procedure via the posteromedial approach. All patients had intraoperative radiographic anatomic reductions, did not have any type of complica- tion during follow-up, and were followed until at least 10 years of age. Unaffected contralateral hips were used as controls. The acetabular angle of Sharp (AA) was measured to determine acetabular development. Mean follow-up was 112 months. A significant difference (p < 0.005) was observed between the mean AA values of affected and unaffected hips at operation and at the first three follow-up visits (mean age was 24, 41, and 56 months, respectively). This significant difference was not present (p > 0.05) at the latest two follow-up visits (mean age was 90 and 124 months, respectively). It can be concluded that a marked radiographic improvement in acetabular slope occurs within 1 year postoperatively. This improvement continues slowly during the childhood period, and the acetabulum attains previously determined normal AA values at nearly 7 to 8 years of age for those patients whose dysplastic hips were anatomically reduced at less than 18 months of age and for those who did not experience complications during follow-up.     

Communication with Patients on Mechanical Ventilation: A Review of Existing Technologies

How to cite this article: Anand A, Nair RR, Kodamanchili S, Panda R, Bhardwaj KK, Gowthaman TB. Communication with Patients on Mechanical Ventilation: A Review of Existing Technologies. Indian J Crit Care Med 2022;26(6):756–757.     

自体骨髓移植治疗淋巴瘤的时机选择

本文报告用自体骨髓移植治疗11例晚期淋巴瘤,获得了良好效果。作者和文献认为,自体骨髓移植不仅是一种有效手段,而且有广泛的适应症。不失时机地用自体骨髓移植治疗淋巴瘤,可使部分晚期病例,获得长期缓解。     

Ocrelizumab Concentration Is a Good Predictor of SARS-CoV-2 Vaccination Response in Patients with Multiple Sclerosis

Ocrelizumab, an anti-CD20 monoclonal antibody, counteracts induction of humoral immune responses after severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) vaccinations in patients with multiple sclerosis (MS). We aimed to assess if serum ocrelizumab concentration measured at the time of vaccination could predict the humoral response after SARS-CoV-2 vaccination. In 52 patients with MS, we found ocrelizumab concentration at the time of vaccination to be a good predictor for SARS-CoV-2 IgG anti-RBD titers after vaccination (comparable to B-cell count). As the course of ocrelizumab concentration may be predicted using pharmacokinetic models, this may be a superior biomarker to guide optimal timing for vaccinations in B-cell depleted patients with MS. ANN NEUROL 2023;93:103–108