全文获取类型
收费全文 | 609篇 |
免费 | 34篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 22篇 |
妇产科学 | 27篇 |
基础医学 | 46篇 |
口腔科学 | 7篇 |
临床医学 | 53篇 |
内科学 | 126篇 |
皮肤病学 | 5篇 |
神经病学 | 154篇 |
特种医学 | 17篇 |
外科学 | 93篇 |
预防医学 | 9篇 |
眼科学 | 2篇 |
药学 | 46篇 |
肿瘤学 | 37篇 |
出版年
2023年 | 6篇 |
2021年 | 8篇 |
2020年 | 8篇 |
2019年 | 8篇 |
2018年 | 20篇 |
2017年 | 14篇 |
2016年 | 9篇 |
2015年 | 10篇 |
2014年 | 15篇 |
2013年 | 20篇 |
2012年 | 22篇 |
2011年 | 30篇 |
2010年 | 11篇 |
2009年 | 9篇 |
2008年 | 49篇 |
2007年 | 44篇 |
2006年 | 33篇 |
2005年 | 42篇 |
2004年 | 26篇 |
2003年 | 30篇 |
2002年 | 28篇 |
2001年 | 32篇 |
2000年 | 24篇 |
1999年 | 24篇 |
1998年 | 4篇 |
1997年 | 4篇 |
1996年 | 9篇 |
1995年 | 3篇 |
1992年 | 7篇 |
1991年 | 6篇 |
1990年 | 5篇 |
1989年 | 9篇 |
1988年 | 8篇 |
1987年 | 9篇 |
1985年 | 3篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1976年 | 2篇 |
1975年 | 4篇 |
1974年 | 6篇 |
1972年 | 4篇 |
1971年 | 3篇 |
1970年 | 4篇 |
1969年 | 3篇 |
1967年 | 2篇 |
1966年 | 5篇 |
1965年 | 2篇 |
排序方式: 共有645条查询结果,搜索用时 140 毫秒
111.
Midori Nakajima Simeon Wong Elysa Widjaja Shiro Baba Tohru Okanishi Lynne Takada Yosuke Sato Hiroki Iwata Maya Sogabe Hikaru Morooka Robyn Whitney Yuki Ueda Tomoshiro Ito Kazuyori Yagyu Ayako Ochi O. Carter Snead James T. Rutka James M. Drake Hiroshi Otsubo 《Clinical neurophysiology》2018,129(6):1182-1191
Objective
To investigate whether advanced dynamic statistical parametric mapping (AdSPM) using magnetoencephalography (MEG) can better localize focal cortical dysplasia at bottom of sulcus (FCDB).Methods
We analyzed 15 children with diagnosis of FCDB in surgical specimen and 3?T MRI by using MEG. Using AdSPM, we analyzed a ±50?ms epoch relative to each single moving dipole (SMD) and applied summation technique to estimate the source activity. The most active area in AdSPM was defined as the location of AdSPM spike source. We compared spatial congruence between MRI-visible FCDB and (1) dipole cluster in SMD method; and (2) AdSPM spike source.Results
AdSPM localized FCDB in 12 (80%) of 15 children whereas dipole cluster localized six (40%). AdSPM spike source was concordant within seizure onset zone in nine (82%) of 11 children with intracranial video EEG. Eleven children with resective surgery achieved seizure freedom with follow-up period of 1.9?±?1.5?years. Ten (91%) of them had an AdSPM spike source in the resection area.Conclusion
AdSPM can noninvasively and neurophysiologically localize epileptogenic FCDB, whether it overlaps with the dipole cluster or not.Significance
This is the first study to localize epileptogenic FCDB using MEG. 相似文献112.
113.
114.
Yasushi Iimura Kevin Jones Kyoko Hattori Yushi Okazawa Atsuko Noda Kana Hoashi Yutaka Nonoda Eishi Asano Tomoyuki Akiyama Cristina Go Ayako Ochi O. Carter Snead Elizabeth J. Donner James T. Rutka James M. Drake Hiroshi Otsubo 《Clinical neurophysiology》2017,128(7):1197-1205
Objective
Subtotal hemispherectomy involves the resection of multiple lobes in children with drug-resistant epilepsy, skipping the motor area (MA). We determined epileptogenicity using the occurrence rate (OR) of high-frequency oscillations (HFOs) and the modulation index (MI), demonstrating strength of coupling between HFO and slow wave. We hypothesized that epileptogenicity increased over the multiple lobes but skipped the MA.Methods
We analyzed 23 children (14 subtotal hemispherectomy; 9 multilobar resections). Scalp video-EEG and magnetoencephalography were performed before surgery. We analyzed the OR(HFO) and MI(5 phases=0.5–8 Hz) on electrodes of total area, resection areas, and MA. We compared the data between good [International League Against Epilepsy (ILAE) class I–II] and poor (III–VI) seizure outcome groups.Results
ILAE class Ia outcome was achieved in 18 children. Among the MI(5 phases) in the resection areas, MI(3–4 Hz) was the highest. The OR(HFO) and MI(3–4 Hz) in both total area and resection areas were significantly higher in the good seizure outcome group than in the poor outcome group. The OR(HFO) and MI(3–4 Hz) in resection areas were significantly higher than in the MA.Conclusions
Our patients with multilobar drug-resistant epilepsy showed evidence of multifocal epileptogenicity that specifically skipped the MA.Significance
This is the first study demonstrating that the electrophysiological phenotype of multifocal epilepsy specifically skips the MA using OR(HFO) and MI(3–4 Hz). 相似文献115.
Safety‐related outcomes of the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery board certification system for expert surgeons 下载免费PDF全文
116.
Saito J Hirota T Kikunaga N Otsubo K Ieiri I 《Journal of pharmaceutical sciences》2011,100(9):3875-3883
Organic cation transporters (OCTs) mediate the transport of organic cations and some drugs (e.g., metformin and cimetidine). OCT1, OCT2, and OCT3 are located in the imprinting cluster of the insulin-like growth factor 2 receptor. It has been reported that OCT1 and OCT3 show a biallelic expression, whereas OCT2 undergoes maternal imprinting in the human placenta; however, a loss of the imprinting of OCT2 has recently been reported in some placental samples. This study investigated whether epigenetic mechanisms are involved in interindividual differences in the placental expression of OCT2. Because OCT2 mRNA levels were higher in biallelic samples than that in monoallelic samples, we compared the DNA methylation and chromatin modifications in the promoter regions. There was no remarkable difference in DNA methylation between the mono allelic samples and biallelic samples. In contrast, histone H3 acetylation (H3Ac) was increased in the biallelic samples. A significant negative correlation was observed between the trimethylation of lysine-9 on histone H3 (H3K9me3) and the OCT2 mRNA levels. Our results suggest that H3Ac plays a role in the allelic expression of OCT2. In addition, H3K9me3 in the OCT2 promoter may explain the interindividual differences in placental OCT2 mRNA levels. 相似文献
117.
Hitoshi Suzuki Hirofumi Hashimoto Makoto Kawasaki Miho Watanabe Hiroki Otsubo Toru Ishikura Hiroaki Fujihara Hideo Ohnishi Etsuro Onuma Hisafumi Yamada‐Okabe Yoh Takuwa Etsuro Ogata Toshitaka Nakamura Yoichi Ueta 《International journal of cancer. Journal international du cancer》2011,128(9):2215-2223
118.
Otsubo S Kawata T Takasaki M Ishihara M Ueda S Sugimoto H Otsubo K Akiba T Nitta K Hirano M 《Internal medicine (Tokyo, Japan)》2011,50(7):733-737
A serotype-1 hepatitis C virus (HCV) infection in a 67-year-old hemodialysis patient was treated using interferon (IFN)-beta. Although the patient had a high RNA titer (5.1 log IU/mL) and had been receiving long-term hemodialysis therapy (30 years), the initial 4-week IFN-beta administration enabled a rapid virological response without any major adverse effects. However, the final outcome after 24 weeks of IFN beta treatment was classified as unchanged based on the criteria of the Conference on Intractable Hepatitis. Here, we describe our experience treating HCV infection using IFN-beta and discuss the indications for such therapy. 相似文献
119.
120.
Masao Murakami Akiyoshi Egashira Keiko Tanaka Chizuru Mine Hitomi Otsubo Takeshi Kuramoto 《Journal of assisted reproduction and genetics》2014,31(12):1605-1610