全文获取类型
收费全文 | 9859篇 |
免费 | 490篇 |
国内免费 | 92篇 |
专业分类
耳鼻咽喉 | 53篇 |
儿科学 | 157篇 |
妇产科学 | 186篇 |
基础医学 | 1481篇 |
口腔科学 | 189篇 |
临床医学 | 579篇 |
内科学 | 2600篇 |
皮肤病学 | 264篇 |
神经病学 | 842篇 |
特种医学 | 324篇 |
外科学 | 1448篇 |
综合类 | 33篇 |
预防医学 | 277篇 |
眼科学 | 153篇 |
药学 | 752篇 |
中国医学 | 23篇 |
肿瘤学 | 1080篇 |
出版年
2023年 | 38篇 |
2022年 | 111篇 |
2021年 | 179篇 |
2020年 | 87篇 |
2019年 | 122篇 |
2018年 | 176篇 |
2017年 | 189篇 |
2016年 | 196篇 |
2015年 | 207篇 |
2014年 | 300篇 |
2013年 | 342篇 |
2012年 | 588篇 |
2011年 | 654篇 |
2010年 | 377篇 |
2009年 | 306篇 |
2008年 | 557篇 |
2007年 | 678篇 |
2006年 | 638篇 |
2005年 | 641篇 |
2004年 | 621篇 |
2003年 | 617篇 |
2002年 | 595篇 |
2001年 | 187篇 |
2000年 | 160篇 |
1999年 | 201篇 |
1998年 | 152篇 |
1997年 | 107篇 |
1996年 | 88篇 |
1995年 | 93篇 |
1994年 | 88篇 |
1993年 | 66篇 |
1992年 | 119篇 |
1991年 | 92篇 |
1990年 | 97篇 |
1989年 | 120篇 |
1988年 | 89篇 |
1987年 | 73篇 |
1986年 | 53篇 |
1985年 | 62篇 |
1984年 | 49篇 |
1983年 | 43篇 |
1982年 | 34篇 |
1981年 | 17篇 |
1980年 | 22篇 |
1979年 | 29篇 |
1977年 | 19篇 |
1976年 | 18篇 |
1974年 | 17篇 |
1973年 | 18篇 |
1969年 | 19篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
51.
Miura T Goto M Hosoya N Odawara T Kitamura Y Nakamura T Iwamoto A 《Journal of medical virology》2003,70(4):497-505
Mitochondrial DNA (mtDNA) of peripheral blood mononuclear cells (PBMCs) collected from Human immunodeficiency virus 1 (HIV-1)-infected patients and healthy controls were measured longitudinally using real-time polymerase chain reaction to evaluate the effects of antiretroviral agents on mtDNA synthesis in vivo and to assess the value of monitoring mtDNA in PBMCs to predict adverse events amongst these patients. MtDNA levels in PBMCs were significantly decreased in treatment-naive HIV-1-infected patients compared with healthy people. MtDNA levels were not only significantly correlated with CD4(+) T-cell count, but also inversely correlated with HIV-1 viral load. MtDNA levels in untreated patients and healthy controls were stable during the period of observation. On the other hand, amongst patients treated with regimens containing AZT/3TC or d4T/3TC, mtDNA increased during treatment and recovered to levels comparable to healthy controls. In contrast, mtDNA decreased immediately after the initiation of an AZT/ddC-containing regimen. We did not find a correlation between mtDNA levels and changes in clinical parameters. There was no significant difference in mtDNA levels between patients with and those without lipoatrophy. Furthermore, there was no obvious difference in mtDNA levels amongst those patients exhibiting signs and symptoms of peripheral neuropathy. In conclusion, the decrease in mtDNA levels in PBMCs amongst HIV-1-infected patients and its amelioration by antiretroviral therapy may suggest the influence of direct effects on mitochondria or mtDNA by HIV-1 infection. Further investigations are needed to elucidate the mechanisms contributing to decreased mtDNA and the value of mtDNA measurement in the care of HIV-1-infected individuals. 相似文献
52.
53.
54.
To clarify the effect of the age of host erythrocytes on the multiplication ofBabesia parasites,B. gibsoni was cultured together with reticulocytes, immature erythrocytes, or mature erythrocytes from dogs. Parasitemia reached peak levels (34.1%±15.8%) at cultivation day 8 in immature-erythrocyte culture, whereas the highest parasitemia attained in mature-cell culture was only 3.6%±2.2% at day 5. These results clearly demonstrate thatB. gibsoni parasites preferentially invade and multiply in young erythrocytes rather than in mature cells. 相似文献
55.
56.
Association of Epstein-Barr virus with oral cancers 总被引:2,自引:0,他引:2
57.
Yasuyuki Sumikawa Yuriko Ueki Akira Miyoshi Lei Cheng Min Yin Hai-Bo Shi Masuko Daitoku Sumikawa Takeshi Kono Toshiyuki Aoki Ichiro Katayama 《Arerugī》2007,56(10):1270-1275
BACKGROUND: The comparative studies of the prevalence of atopic dermatitis and skin barrier functions in Japanese and Chinese were performed. METHODS: Clinical investigations were performed in 68 elementary school students in Lhasa, Tibet Autonomous Region and 67 students in Yixing, Jiangsu Province in China, and 99 students in Nishinomiya, Hyogo in Japan. Transepidermal water loss (TEWL) and capacitance were measured. Questionary survey about bathing frequency was also performed for students in Lhasa, Yixing and Osaka. RESULT: The prevalence rate of atopic dermatitis was 0% in Lhasa, 2.63% in Yixing, 4.26% in Nishinomiya. TEWL of students in Nishinomiya was higher than that in Yixing and Lhasa. Capacitance of students in Lhasa was lower than that in Nishinomiya and Yixing. The frequency of taking a bath in Lhasa was about 2.2 times per month and fewer than that in Nishinomiya and Yixing. CONCLUSION: There was tendency that the prevalence of atopic dermatitis increased according to increase of TEWL. It was thought that more investigations are necessary whether the development of habitat and environment influence the prevalence of atopic dermatitis and skin barrier function. 相似文献
58.
59.
Zou Jian-Ping; Yamamoto Norihiko; Fujii Tetsuya; Takenaka Hiroshi; Kobayashi Michiko; Herrmann Steven H.; Wolf Stanley F.; Fujiwara Hiromi; Hamaoka Toshiyuki 《International immunology》1995,7(7):1135-1145
Unfractionated spleen cells taken from tumor-bearing mice 2weeks after tumor implantation contained tumor-primed T cellswhich produced cytokines including IL-2 and IFN- when culturedin vitro. With progressive tumor growth this initial lymphokine-producingcapacity decreased. Here, we investigated the ability of IL-12to (I) restore suppressed IFN- production, (II) cause tumorregression and (II) induce anti-tumor protective immunity. Additionof rIL-12 to spleen cell cultures from 4- to 10-week-old tumor-bearingmice resulted in a striking enhancement in the production ofIFN- compared with cultures of these cells in the absence ofrIL-12 or of normal spleen cells in the presence of rIL-12.Five I.p. injections of rIL-12 into mice bearing s.c. tumorsinduced complete tumor regression. This was found when rIL-12was given at early (1–2 weeks), intermediate (4–5weeks) or even late (7 weeks) stages of tumor growth. Furthermore,IL-12-treated mice which rejected the primary tumor exhibitedcomplete resistance to a rechallenge with the same tumor butdid not reject a second syngenetic tumor. Immunohistochemicalanalyses following IL-12 treatment revealed that CD4+ and CD8+T cells infiltrate the tumor. More importantly, IFN- mRNA expressionwas observed in fresh tumor masses from tumor-bearing mice receivingIL-12 treatment The importance of IFN- was further demonstratedby the observation that the systemic administration of anti-IFN-mAb prior to IL-12 treatment completely abrogated the anti-tumoreffect of IL-12. Thus, these results indicate that administrationof modest levels of rIL-12 to tumor-bearing mice results intumor regression through mechanisms involving reversal of suppressedIFN- production by anti-tumor T cells and the establishmentof a tumor-specific protective immune response. 相似文献
60.