全文获取类型
收费全文 | 2720篇 |
免费 | 129篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 67篇 |
妇产科学 | 62篇 |
基础医学 | 350篇 |
口腔科学 | 73篇 |
临床医学 | 192篇 |
内科学 | 592篇 |
皮肤病学 | 81篇 |
神经病学 | 177篇 |
特种医学 | 88篇 |
外科学 | 411篇 |
综合类 | 6篇 |
预防医学 | 105篇 |
眼科学 | 34篇 |
药学 | 305篇 |
中国医学 | 4篇 |
肿瘤学 | 294篇 |
出版年
2022年 | 32篇 |
2021年 | 40篇 |
2020年 | 32篇 |
2019年 | 26篇 |
2018年 | 44篇 |
2017年 | 32篇 |
2016年 | 43篇 |
2015年 | 34篇 |
2014年 | 41篇 |
2013年 | 89篇 |
2012年 | 131篇 |
2011年 | 124篇 |
2010年 | 75篇 |
2009年 | 64篇 |
2008年 | 134篇 |
2007年 | 140篇 |
2006年 | 143篇 |
2005年 | 154篇 |
2004年 | 139篇 |
2003年 | 132篇 |
2002年 | 157篇 |
2001年 | 76篇 |
2000年 | 76篇 |
1999年 | 65篇 |
1998年 | 41篇 |
1997年 | 34篇 |
1996年 | 31篇 |
1995年 | 22篇 |
1994年 | 18篇 |
1993年 | 28篇 |
1992年 | 51篇 |
1991年 | 62篇 |
1990年 | 53篇 |
1989年 | 42篇 |
1988年 | 40篇 |
1987年 | 30篇 |
1986年 | 62篇 |
1985年 | 42篇 |
1984年 | 27篇 |
1983年 | 18篇 |
1982年 | 19篇 |
1979年 | 32篇 |
1978年 | 28篇 |
1977年 | 19篇 |
1976年 | 11篇 |
1974年 | 13篇 |
1973年 | 13篇 |
1972年 | 18篇 |
1971年 | 14篇 |
1969年 | 10篇 |
排序方式: 共有2863条查询结果,搜索用时 0 毫秒
41.
Aoyama T Shimizu T Matsuo T Sakamoto H Kamata K Higashihara M Tsuji H Shigematsu H Kobayashi Y 《Internal medicine (Tokyo, Japan)》2002,41(6):458-462
A 37-year-old woman had been found to have proteinuria in October 1996. About 8 months later, the first renal biopsy was performed, revealing focal segmental necrotizing and crescentic glomerulonephritis. At that time, serum creatinine was 1.0 mg/dl and urinary protein 3+. In October 1999, laboratory tests revealed positivity for MPO-ANCA and a serum creatinine level of 1.42 mg/dl, anemia and proteinuria of 2+. A second renal biopsy showed almost the same histological findings. Accordingly, a diagnosis of MPO-ANCA positive glomerulonephritis was made. This patient was thought to be a rare case of MPO-ANCA-positive slowly progressive glomerulonephritis presenting focal segmental tuft necrosis and crescents. 相似文献
42.
43.
44.
45.
46.
47.
Hatano H Kudo Y Ogawa I Shimasue H Shigeishi H Ohta K Higashikawa K Takechi M Takata T Kamata N 《Oral diseases》2012,18(8):756-762
Oral Diseases (2012) 18, 756-762 Objectives: An odontoma, which shows proliferating odontogenic epithelium and mesenchymal tissue, is one of the most common odontogenic tumors encountered. These are commonly found in tooth-bearing regions, although the etiology remains unknown. There are no previous reports of an established line of immortalized human odontoma cells. Methods: Using odontoma fragments obtained from a girl treated at our department, we established an immortalized human odontoma cell line and investigated cell morphology, dynamic proliferation, the presence of contamination, and karyotype. Moreover, cell characterization was examined using osteogenic and odontogenic markers. Results: We successfully established a mesenchymal odontoma cell (mOd cells). The cells were found to be fibroblastic and had a high level of telomerase activity. Cell growth was confirmed after more than 200 population doublings without significant growth retardation. mOd cells expressed mRNA for differentiation markers, including collagen type I (COLI), alkaline phosphatase, bone sialoprotein, osteopontin, osteocalcin, cementum-derived protein (CP-23), dentin sialophosphoprotein (DSPP), and distal-less homeobox 3 (DLX3), as well as bone morphogenetic proteins (BMPs). In addition, they showed a high level of calcified nodule formation activity in vitro. Conclusions: We successfully established a cell line that may be useful for investigating the mechanisms of normal odontogenesis as well as characteristics of odontoma tumors. 相似文献
48.
49.
50.
Ebara S Song SN Mizuta H Ito Y Hasegawa K Kamata T Matsumura-Nishikawa T Ogawa T Soneda J Yoshizaki K 《International journal of hematology》2012,95(2):198-203
Dysregulated overproduction of interleukin-6 (IL-6) from activated B cells in affected lymph nodes has been implicated in
the pathogenesis of multicentric Castleman’s disease (MCD), a rare lymphoproliferative disorder accompanied by systemic manifestations.
We here report the case of a 32-year-old female presenting with MCD associated with a dermoid cyst in the pelvic cavity. The
co-occurrence of MCD and dermoid cyst has not been reported before. Immunohistochemical analysis of the tissue sections showed
IL-6 production in CD68-positive macrophage cells, which had infiltrated the dermoid cyst. Removal of the cyst resulted in
partial improvement in systemic symptoms accompanied by a decrease in serum IL-6, while complete improvement was obtained
by treatment with an anti-IL-6 receptor antibody following resection of the dermoid cyst. To the best of our knowledge, this
is the first study to provide evidence of IL-6 production by CD68+ cells in a dermoid cyst involved in MCD. 相似文献