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31.
Hiroyuki?Takahama Masanori?Asakura Yukio?Abe Masayoshi?Ajioka Kazutaka?Aonuma Toshihisa?Anzai Takaharu?Hayashi Shinya?Hiramitsu Hiroya?Kawai Hidetaka?Kioka Kazuo?Kimura Young-Jae?Lim Ken?Matsuoka Hirohiko?Motoki Yoji?Nagata Sunao?Nakamura Nobuyuki?Ohte Yukio?Ozaki Taishi?Sasaoka Shunsuke?Tamaki Toshimitsu?Hamasaki Masafumi?Kitakaze 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2018,32(4):381-388
Background
Previous studies suggest that the pathophysiology of heart failure with preserved ejection fraction (HFpEF) is characterized not only by high ventricular stiffness, but also by vascular stiffness. Azilsartan has higher vascular affinity compared with other angiotensin II receptor blockers (ARBs), which were proven to have no beneficial effects on clinical outcomes in patients with HFpEF in earlier clinical trials. We aimed to test the hypothesis that azilsartan may improve left ventricular diastolic function in HFpEF patients with hypertension in this trial.Methods
The Effects of Angiotensin Receptor Blockers on Diastolic Function in Patients Suffering from Heart Failure with Preserved Ejection Fraction: J-TASTE trial is a multicenter, randomized, open-labeled, and assessor(s)-blinded, active controlled using candesartan, parallel-group clinical trial, to compare changes in left ventricular (LV) diastolic dysfunction between HFpEF patients with hypertension who have received candesartan or azilsartan for 48 weeks. The primary endpoint is the change in early diastolic wave height/early diastolic mitral annulus velocity (E/e’) assessed by echocardiography from the baseline to the end of the study (48 weeks). A total of 190 patients will be recruited into the study.Conclusions
The design of the J-TASTE trial will provide data on whether differences between the effects of the two tested drugs on LV diastolic function exist in HFpEF patients with hypertension and will improve understanding of the pathophysiological role of vascular stiffness on diastolic function.32.
Gastric cancer with metastasis to the gingiva 总被引:3,自引:0,他引:3
Shimoyama S Seto Y Aoki F Ogawa T Toma T Endo H Itouji T Kaminishi M 《Journal of gastroenterology and hepatology》2004,19(7):831-835
The present case report describes a gastric cancer which showed unusual metastasis in the oral region. A 56-year-old male patient underwent total gastrectomy and splenectomy due to advanced gastric cancer in the upper third of the stomach. Fifteen months later, he presented with anorexia and gingival swelling of durations of approximately 3 and 1 month, respectively. The gastric tumor was histologically a signet ring cell and a poorly differentiated cancer with a moderate degree of vascular invasion. Biopsy specimens from the gingival tumor revealed a signet ring cell cancer. Other metastatic sites were the brain, limb bones and abdominal lymph nodes. A bone scintigram revealed an abnormal uptake in the limb bones, while it did not exhibit any abnormality in the oral region. Correlation between the histology of the gingival tumor with that of the gastric cancer, as well as the absence of a gingival tumor at the time of prior gastrectomy, led to a diagnosis that the gingival tumor was a metastasis from gastric cancer. Gastric cancer metastasizing to the oral region, either the osseus or the oral soft tissue, is very rare. Although it cannot be proved without an autopsy, negative findings in the mandible by bone scanning in the present case suggest that direct gingival metastasis can be considered, rather than mandibular metastasis involving the gingiva. Hematogenous spread could be a mechanism of metastasis for this unusual tumor. 相似文献
33.
34.
Takashi Morihara Noriyuki Hayashi Mikiko Yokokoji Hiroyasu Akatsu Michael A. Silverman Nobuyuki Kimura Masahiro Sato Yuhki Saito Toshiharu Suzuki Kanta Yanagida Takashi S. Kodama Toshihisa Tanaka Masayasu Okochi Shinji Tagami Hiroaki Kazui Takashi Kudo Ryota Hashimoto Naohiro Itoh Kouhei Nishitomi Yumi Yamaguchi-Kabata Tatsuhiko Tsunoda Hironori Takamura Taiichi Katayama Ryo Kimura Kouzin Kamino Yoshio Hashizume Masatoshi Takeda 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(7):2638-2643
35.
Asai Shuji Takahashi Nobunori Terabe Kenya Sobue Yasumori Nishiume Tsuyoshi Suzuki Mochihito Yokota Yutaka Ishiguro Naoki Kojima Toshihisa 《Clinical rheumatology》2020,39(11):3331-3339
Clinical Rheumatology - Periarticular osteophyte formation is observed during the repair of damaged joints in rheumatoid arthritis (RA); however, little is known about its clinical and functional... 相似文献
36.
Akitoshi Hakoda Toshihisa Takeuchi Yuichi Kojima Yasuhiro Fujiwara Yasuaki Nagami Yuji Naito Shinsaku Fukuda Tomoyuki Koike Mitsushige Sugimoto Kenta Hamada Hideki Kobara Norimasa Yoshida Tomoki Inaba Akihito Nagahara Eriko Koizumi Kazunari Murakami Takahisa Furuta Naotaka Ogasawara Hajime Isomoto Kotaro Shibagaki Hiromi Kataoka Hidekazu Suzuki Kazuhide Higuchi 《Journal of Clinical Biochemistry and Nutrition》2022,70(2):189
Bleeding after gastric endoscopic submucosal dissection (ESD) remains problematic, especially in patients receiving antithrombotic therapy. Therefore, this study aimed to identify the risk factors. In this retrospective study, patients (n = 1,207) who underwent gastric ESD while receiving antithrombotic therapy were enrolled at Osaka Medical and Pharmaceutical University Hospital and 18 other referral hospitals in Japan. Risks of post-ESD bleeding were calculated using multivariable logistic regression. The dataset was divided into a derivation cohort and a validation cohort. We created a prediction model using the derivation cohort. The accuracy of the model was evaluated using the validation cohort. Post-ESD bleeding occurred in 142 (11.8%) participants. Multivariable analysis yielded an odds ratio of 2.33 for aspirin, 4.90 for P2Y12 receptor antagonist, 1.79 for cilostazol, 0.95 for other antithrombotic agents, 6.53 for warfarin, 5.65 for dabigatran, 7.84 for apixaban, 10.45 for edoxaban, 6.02 for rivaroxaban, and 1.46 for heparin bridging. The created prediction model was called safe ESD management using the risk analysis of post-bleeding in patients with antithrombotic therapy (SAMURAI). This model had good predictability, with a C-statistic of 0.77. In conclusion, use of the SAMURAI model will allow proactive management of post-ESD bleeding risk in patients receiving antithrombotic therapy. 相似文献
37.
Zi-chen CHEN Yu-zhong ZHANG Huan-di ZHAO Xinyu WEI Toshihisa Murofushi Juan HU Ying CHENG Fei-yun CHEN Xin-da XU Min XU Qing ZHANG 《华中科技大学学报(医学英德文版)》2021,(4):695-704
Objective:Auditory neuropathy(AN)is a unique pattern of hearing loss with preservation of hair cell function.The condition is characterized by the presence of o... 相似文献
38.
Clinical impact of the presence of macrophages in endomyocardial biopsies of patients with dilated cardiomyopathy 下载免费PDF全文
39.
40.
Kazuhiro Ota Shimpei Kawaguchi Taro Iwatsubo Shinya Nishida Hironori Tanaka Yosuke Mori Noriyuki Nakajima Akitoshi Hakoda Noriaki Sugawara Yuichi Kojima Toshihisa Takeuchi Masahiro Sakaguchi Kazuhide Higuchi 《Internal medicine (Tokyo, Japan)》2022,61(3):335
A 77-year-old man complained of postmeal vomiting and sustained general fatigue. An abdominal computed tomography scan showed massive gastric expansion and fluid storage. Gastroscopy revealed four gastric bezoars that were considered to have caused pyloric ring obstruction. The patient was asked to drink 500 mL per day of Coca-ColaⓇ for 4 days. On the fourth day, we performed endoscopic crushing and removal by injecting Coca-ColaⓇ, cutting the softened bezoar with endoscopic snares, and collecting the pieces with endoscopic nets. We herein report (with a video presentation) a rare case of tannin-phytobezoars endoscopically removed with the administration and injection of Coca-ColaⓇ. 相似文献