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排序方式: 共有102条查询结果,搜索用时 15 毫秒
81.
Silins SL; Cross SM; Elliott SL; Pye SJ; Burrows JM; Moss DJ; Misko IS 《International immunology》1997,9(11):1745-1755
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Nasopharyngeal carcinoma (NPC) in childhood occurs so infrequently that it is not suspected in affected children until the disease has been present for a long time and local spreading has occurred. The survival rates are therefore quite poor. Six children with NPC are described. A massive local lymph node spread simulating lymphoma was present in half of the patients; in the other half the disease was more subtle, presenting with epistaxis and CNS involvement. If an evaluation of the nasopharynx were part of the initial physical examination in children, the diagnosis of NPC would be made earlier and survival rates would improve. 相似文献
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85.
Anthracyclines are effective in breast cancer and have in vitro cytotoxicity in glioma. In patients with glioma anthracyclines are not effective possibly because the hydrophilic drugs do not reach cytotoxic levels in tumor tissue. Idarubicin is more lipophilic than the other anthracyclines and is more cytotoxic in glioma cell lines. The uptake of idarubicin and its major metabolite idarubicinol in brain tumor tissue were measured in a patient with a brain metastasis from breast cancer and in 4 patients with malignant glioma after an oral dose of idarubicin (45 mg/m2 in 1 patient; 25 mg/m2 in 4 patients), given 15–24 h before brain tumor resection. The concentrations of idarubicin and of idarubicinol in tumor tissue exceeded the concurrent plasma concentrations as well as the peak plasma concentrations in all cases. The median tumor: concurrent plasma ratio of idarubicinol was 5.7 (range 1.7–18). The concentration of idarubicinol in the marginal zone between brain and tumor tissue was lower than in central tumor tissue, but was still higher than the plasma concentration in 2 of the 3 examined cases. Bone marrow suppression (platelets CTC grade 2, granulocytes CTC grade 4) occurred after a single dose of 45 ml/m2. No toxicity was seen at a dose of 25 mg/m2. These results, the in vitro activity of idarubicin in glioma, the convenience of oral administration, and its toxicity profile make clinical studies with idarubicin in malignant glioma, and perhaps also in brain metastases from breast cancer worthwhile. 相似文献
86.
Andréa BC Fialho Manuel B Braga-Neto Eder JC Guerra André MN Fialho Karine C Fernandes Juliana LM Sun Christianne FV Takeda Cícero IS Silva Dulciene MM Queiroz Lucia LBC Braga 《BMC gastroenterology》2011,11(1):13
Background
This study conducted in Northeastern Brazil, evaluated the prevalence of H. pylori infection and the presence of gastritis in HIV-infected patients. 相似文献87.
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Nishikawa A; Tanakamura Z; Furukawa F; Lee IS; Kasahara K; Ikezaki S; Takahashi M 《Carcinogenesis》1998,19(2):365-368
The modifying effects of oltipraz on induction of glandular stomach
carcinogenesis by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were
investigated in a total of 120 male 6-week-old Wistar rats, divided into
six groups. Groups 1-3 (30 animals each) were given 100 p.p.m. MNNG in
their drinking water for 10 weeks as an initiation treatment for gastric
cancer induction and respectively fed diets supplemented with 0.04%, 0.02%
and 0% oltipraz for 12 weeks, starting 1 week before and finishing 1 week
after the carcinogen exposure. Groups 4-6 (10 animals each) were similarly
treated without the application of MNNG. At the end of the 80th
experimental week, all surviving animals were autopsied and examined
histopathologically for the existence of gastric proliferative lesions. The
incidence and multiplicity of adenocarcinomas were significantly (P <
0.01) lower in group 1 than in group 3. In addition, the multiplicity of
atypical hyperplasias in the pyloric region was significantly (P < 0.05)
decreased in group 1 as compared with the group 3 value. No gastric
proliferative lesions were found in groups 4-6. In an additional short-term
experiment, oltipraz significantly reduced cell proliferative activity (P
< 0.01) and elevated glutathione levels (P < 0.05) in the glandular
stomach mucosa of rats treated with MNNG. Thus our results clearly indicate
that oltipraz can inhibit induction of proliferative glandular stomach
lesions by MNNG in the rat.
相似文献
90.
AnewratmodelofportalhypertensioninducedbyintraportalinjectionofmicrospheresLIXiangNong1,ISBenjamin2andBAlexander2Subjecthead... 相似文献