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181.
Vitamin D levels and disease status in Texas patients with systemic lupus erythematosus 总被引:1,自引:0,他引:1
Thudi A Yin S Wandstrat AE Li QZ Olsen NJ 《The American journal of the medical sciences》2008,335(2):99-104
OBJECTIVES: Previous studies have suggested a relationship between low serum levels of vitamin D and lupus. Vitamin D receptor ligands can mediate immunosuppressive effects and low levels of this hormone have been proposed as contributing to the immune activation in lupus and other autoimmune diseases. We sought to investigate the prevalence of vitamin D insufficiency in our patients with lupus. METHODS: Serum levels of 25-OH vitamin D were measured in 37 female patients with lupus using an enzyme-linked immunoassay. Correlations with clinical and immunologic measures were determined. RESULTS AND CONCLUSIONS: Approximately 65% of the patients with lupus had values less than 80 nmol, which is accepted as the lower limit of vitamin D adequacy. In addition, 20% of the subjects had levels of 25-hydroxyvitamin D that were lower than the normal range for the assay (<47.7 nmol/L). The group of patients with these lowest levels showed disease activity measures, including global assessment scores, that were higher in the than in those with levels considered normal in the assay (P < or = 0.003). However, levels of autoantibodies including dsDNA were higher in the group with levels of vitamin D that were greater than 47.7 nmol/L (P = 0.0069). The increased disease symptoms present in patients with very low levels of vitamin D suggests a role for supplementation with exogenous vitamin D to optimize therapeutic outcomes. However, the possibility that such treatment could lead to increased autoantibody levels requires further study. 相似文献
182.
Archana C Buch Harsh Kumar NK Panicker Sonali Misal YK Sharma Charusheela R Gore 《Indian journal of dermatology》2014,59(4):364-368
Background:
Autoimmune blistering diseases are a group of bullous disorders characterized by pathogenic antibodies directed at the target antigens, which are components of the desmosomes or adhesion complex at the dermoepidermal junction. Direct immunofluorescence (DIF) is invaluable in the diagnosis of these lesions.Aim:
The aim of this study was to evaluate the sensitivity of DIF in immunobullous dermatoses and to study the pattern of DIF. The study also aims to correlate DIF with clinical and histologic findings and to analyze discrepancies.Materials and Methods:
Total 100 biopsies received over a period of 2 years in the Department of Pathology were analyzed. DIF, histopathology and clinical data were reviewed.Results:
Out of 100, 89 cases showed DIF patterns concordant with clinical/histologic diagnosis. The sensitivity of DIF was 94.44% (51/58) in the pemphigus and 84% (21/25) in the bullous pemphigoid (BP) group, 100% each in dermatitis herpetiformis (2/2) and linear IgA disease (1/1). A total of 11 histologically proven cases of immunobullous lesions were DIF negative-four (three of pemphigus vulgaris and one of BP) due to having no epidermis, three (cases of BP) owing to sampling/technical errors and the remaining four (cases of pemphigus vulgaris) due to being on treatment.Conclusion:
Immunofluorescence helps confirm the diagnosis of bullous lesions in which there is clinical and the histopathologic overlap. Sampling errors contributed to false negative (FN) results. 相似文献183.
184.
Scrotal pain and swelling are common presentations in children and are usually secondary to torsion of the testis, hydatid of Morgagni or epididymo-orchitis. Fournier’s gangrene is a rare, but life-threatening disease, that can present in a similar fashion. We present a rare case of Fournier’s gangrene in a 5-year-old boy associated with a preceding varicella rash. 相似文献
185.
CRM Lammens EMA Bleiker S Verhoef FJ Hes MGEM Ausems D Majoor‐Krakauer RH Sijmons RB Van Der Luijt AMW Van Den Ouweland Tam Van Os N Hoogerbrugge EB Gómez García CJ Dommering CM Gundy NK Aaronson 《Clinical genetics》2010,77(5):483-491
Lammens CRM, Bleiker EMA, Verhoef S, Hes FJ, Ausems MGEM, Majoor‐Krakauer D, Sijmons RH, Luijt van der RB, Ouweland van den AMW, Van Os Tam, Hoogerbrugge N, Gomez‐Garcia EB, Dommering CJ, Gundy CM, Aaronson NK. Psychosocial impact of von Hippel–Lindau disease: levels and sources of distress. Von Hippel–Lindau disease (VHL) is a hereditary tumor susceptibility syndrome, characterized by an increased risk of developing multiple benign and malignant tumors at various sites and ages with limited preventive options. This study evaluates the prevalence of distress among VHL family members and factors associated significantly with such distress. Forty‐eight families with a VHL mutation were identified via the nine family cancer clinics in the Netherlands. In total, 171 family members (carriers, 50% at‐risk, non‐carriers) were approached, of whom 123 (72%) completed a self‐report questionnaire. Approximately 40% of the VHL family members reported clinically relevant levels of distress, approaching 50% among the carriers and, possibly even more striking, 36% among the non‐carriers. Having lost a first degree relative due to VHL during adolescence (OR 11.2; 95% CI 1.4–86.9) was related significantly to heightened levels of distress. Approximately, only one‐third of those who reported heightened levels of distress had received professional psychosocial support. A substantial percentage of family members experience clinically relevant levels of distress. We would recommend the introduction of a procedure for screening for distress in this vulnerable population. Special attention should be paid to those individuals who have lost a close relative due to VHL during adolescence. 相似文献
186.
Marier JF Dimarco M Guilbaud R Dodard C Morelli G Tippabhotla SK Singla AK Thudi NR Monif T 《Journal of clinical pharmacology》2007,47(11):1381-1389
The pharmacokinetics of 150 mg lamivudine, 300 mg zidovudine, and 200 mg nevirapine were assessed following single oral administration of a fixed-dose combination tablet and coadministration of the separate innovator products in healthy male subjects (n = 64) under fasting conditions in an open-label, randomized, 2-way crossover study. Multiple blood samples were collected up to 72 hours and plasma concentrations of antiretrovirals were assayed using liquid chromatography/tandem mass spectrometry methods. Pharmacokinetic parameters were calculated using noncompartmental methods, and bioequivalence was assessed using an analysis of variance model. The ratio of the least squares mean (fixed-dose combination to individual products) and 90% confidence intervals of AUC(0-t), AUC(0-infinity), and C(max) for lamivudine, zidovudine, and nevirapine were all within 80.0% to 125.0%, suggesting a similar rate and extent of antiretroviral exposure in the bloodstream. Mean oral clearance (CL/F) values of lamivudine, zidovudine, and nevirapine for the fixed-dose combination were 23.7, 127, and 1.65 L/h, respectively. The fixed-dose combination and individual products were equally safe and well tolerated, with only a few subjects experiencing drug-related adverse events. The current fixed-dose combination of lamivudine, zidovudine, and nevirapine is expected to provide a similar efficacy/safety profile as coadministration of the individual products, a better adherence to treatment, and considerable cost savings in the treatment of HIV. 相似文献
187.
BK Goyal Premansu Roy PM Bhat NK Das KG Paul BS Duggal 《Medical Journal Armed Forces India》2012,68(2):129-131