THE ANTIBODY RESPONSE OF RABBITS TO INJECTIONS OF EMULSIONS AND EXTRACTS OF HOMOLOGOUS BRAIN

Rabbits injected with fresh emulsions of homologous brain developed few or no antibodies capable of fixing complement in the presence of aqueous emulsions or alcoholic extracts of rabbit brain. Complement-fixing antibodies, however, were produced in rabbits by means of injections (1) of sterile emulsions of homologous brain which had been allowed to stand at room temperature for 5 to 30 days and (2) of emulsions of homologous brain experimentally infected with vaccine virus. The antisera that were produced following injections of emulsions of autolyzed homologous brain were shown by absorption tests to contain both specific and non-specific antibodies. The specific brain antigen was found to be approximately six times as abundant in the white matter as in the grey. It was almost absent from the brain of fetal and newly born rabbits, but increased in amount with the age of the animal to reach a maximum concentration at maturity. The specific antigen seemed to parallel the myelin content of brain tissue.     

TREATMENT OF EXPERIMENTAL ACUTE GENERAL PERITONITIS IN THE DOG WITH ILEOSTOMY AND SODIUM CHLORIDE SOLUTION

1. In experimentally produced general peritonitis drainage of the gut by ileostomy 6 inches above the cecum has no beneficial effect. 2. Animals with experimentally produced general peritonitis treated with ileostomy plus 1 per cent sodium chloride solution live three times as long as those not given the salt solution.     

EXPERIMENTAL HIGH INTESTINAL OBSTRUCTION IN THE MONKEY

The blood findings in five monkeys after experimental high intestinal obstruction are reported. All animals showed the marked rise in non-protein nitrogen characteristic of intestinal obstruction in man and the dog. Two monkeys showed a very marked drop in chlorides, the others a less marked fall. Coincident with the change in chlorides there is a rise in the CO₂-combining power. The uric acid and creatinine showed no typical changes. No vomiting was observed. This emphasizes the fact that vomiting alone does not account for the fall in blood chlorides characteristic of intestinal obstruction.     

SKIN INFECTION OF RABBITS WITH HEMOLYTIC STREPTOCOCCI ISOLATED FROM A PATIENT WITH ERYSIPELAS : I. METHOD OF DEMONSTRATING PROTECTIVE ACTION OF IMMUNE SERA.

Cultures of a hemolytic streptococcus isolated from a human case of erysipelas were tested for ability to produce lesions by injecting various amounts intradermally in shaved rabbits. Severe lesions could be developed at will in this way despite the fact that intravenous or intraperitoneal inoculations of large doses of the cultures failed to kill. The lesions were of two sorts, phlegmonous and erysipelas-like. A serum capable of warding off the injurious action of the streptococcus on the skin was procured from animals receiving repeated intracutaneous inoculations of the organism. Normal serum by contrast had no protective effect. By intradermal injections at several points in the same normal rabbit of small quantities of mixtures of equal parts of serum and various dilutions of a suspension of streptococci it proved possible to test sera for the presence of substances protective against the streptococcus.     

Kann man zur Zeit die von Wassermannsche Reaktion auf aktive Tuberkulose im Kindesalter zur Scheidung der aktiven und inaktiven Tuberkulosen verwerten?

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