全文获取类型
收费全文 | 507篇 |
免费 | 15篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 2篇 |
妇产科学 | 2篇 |
基础医学 | 72篇 |
口腔科学 | 35篇 |
临床医学 | 31篇 |
内科学 | 56篇 |
神经病学 | 25篇 |
特种医学 | 15篇 |
外科学 | 147篇 |
综合类 | 3篇 |
预防医学 | 19篇 |
眼科学 | 3篇 |
药学 | 56篇 |
肿瘤学 | 49篇 |
出版年
2023年 | 3篇 |
2022年 | 4篇 |
2021年 | 10篇 |
2020年 | 3篇 |
2019年 | 7篇 |
2018年 | 9篇 |
2017年 | 3篇 |
2016年 | 6篇 |
2015年 | 4篇 |
2014年 | 5篇 |
2013年 | 8篇 |
2012年 | 28篇 |
2011年 | 24篇 |
2010年 | 15篇 |
2009年 | 12篇 |
2008年 | 21篇 |
2007年 | 19篇 |
2006年 | 17篇 |
2005年 | 34篇 |
2004年 | 26篇 |
2003年 | 27篇 |
2002年 | 14篇 |
2001年 | 19篇 |
2000年 | 18篇 |
1999年 | 15篇 |
1998年 | 4篇 |
1997年 | 5篇 |
1996年 | 2篇 |
1995年 | 5篇 |
1994年 | 6篇 |
1993年 | 2篇 |
1992年 | 20篇 |
1991年 | 16篇 |
1990年 | 18篇 |
1989年 | 16篇 |
1988年 | 10篇 |
1987年 | 13篇 |
1986年 | 6篇 |
1985年 | 2篇 |
1984年 | 6篇 |
1982年 | 4篇 |
1978年 | 3篇 |
1977年 | 5篇 |
1974年 | 2篇 |
1972年 | 2篇 |
1971年 | 5篇 |
1970年 | 3篇 |
1969年 | 3篇 |
1968年 | 3篇 |
1967年 | 4篇 |
排序方式: 共有522条查询结果,搜索用时 15 毫秒
81.
82.
Nonspecific recruitment of lymphocytes in purified protein derivative-induced lymphocyte proliferative response of patients with tuberculosis. 总被引:3,自引:2,他引:1
下载免费PDF全文
![点击此处可从《Infection and immunity》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Peripheral blood lymphocytes (PBL) from tuberculosis patients were studied for their in vitro proliferative response stimulated with purified protein derivative (PPD)-tuberculin. Studies were designed to characterize the lymphocytes involved in the PPD-induced proliferation. PPD-responsive lymphocytes were eliminated in PBL by the procedure of cultivation of PBL with PPD in the presence of 5-bromodeoxyuridine and light illumination of the cultured cells. These PBL which lost PPD reactivity were no longer able to proliferate to PPD stimulation but were still capable of proliferation in the presence of both PPD and X-irradiated, autologous fresh PBL or upon addition of culture fluids from PPD-stimulated PBL. In addition, these nonspecifically activated lymphocytes released a soluble factor into the culture fluids which inhibited the migration of leukocytes. It was likely that large numbers of nonspecific T cells were induced to proliferate as a result of the presentation of specific T cells with the antigen PPD. It is suggested that a similar recruitment of lymphocytes by PPD-stimulated T cells takes place in vivo during the establishment of tuberculosis or antituberculous immunity or both. 相似文献
83.
84.
Taihei Miyakawa Motonori Deshimaru Shiro Sumiyoshi Aoi Teraoka Nobuaki Udo Eisei Hattori Seijun Tatetsu 《Acta neuropathologica》1970,15(1):45-55
Summary Organic mercury firstly affects peripheral nerves all over the nervous system. In peripheral nerves, pathological changes are selectively observed in sensory nerve fibres and are as follows: Swelling and degeneration of Schwann cells, noticeable changes in both myelin sheaths and axons. Proliferating cells such as Schwann cells and macrophages may be acting the role of removal and digestion of degenerated myelin and axon. The pathological changes in myelinated fibres tend to begin at the nodes of Ranvier. With the quantity of organic mercury which was administered, only peripheral nerves were injured. From this point of view, we speculate that, of the neurological signs, only sensory disturbance might be found in some of the patients poisoned by organic mercury.
Zusammenfassung Organische Quecksilberverbindungen schädigen im Nervensystem zunächst die peripheren Nerven. Dabei werden die sensiblen Fasern bevorzugt betroffen: es kommt zur Proliferation und Degeneration der Schwannschen Zellen sowie zu starken Veränderungen an Markscheiden und Axonen. Vermehrte Schwannsche Zellen und Makrophagen bewirken die Beseitigung und Verdauung degenerierter Markscheiden und Axone. Die Veränderungen an markhaltigen Nervenfasern beginnen hauptsächlich am Ranvierschen Schnürring. Organisches Quecksilber schädigt in einer bestimmten Dosierung ausschließlich die peripheren Nerven. Diese Befunde lassen vermuten, daß bei Patienten mit organischen Quecksilbervergiftungen mitunter nur Symptome von Schäden an sensiblen Nerven auftreten können.相似文献
85.
S Teraoka M Sugawara Y Kitano T Hoshino M Takahashi Y Minagawa S Naganuma T Sanaka M Mineshima K Era 《The International journal of artificial organs》1989,12(4):229-233
Leukocyte kinesis in the capillary vascular bed during hemodialysis (HD) was investigated to elucidate the mechanism of transient leukopenia. Leukocyte movement was observed microscopically during HD using the rabbit ear chamber (REC) technique, which permits visualization of the movement of blood corpuscles in capillaries. Blood was drawn from the femoral artery and returned into the auricular and/or carotid artery so that the blood passing through the hollow fiber artificial kidney (HFAK) flowed into capillaries in the REC. Leukocyte counts of blood samples taken from the afferent and efferent limbs of the HD circuit, the right jugular vein and the right atrium were determined consecutively during HD. The difference in the leukocyte count was observed between the afferent and efferent limbs for the first 15 minutes and thereafter between the efferent limb and the jugular vein. The "transpulmonary" difference in the leukocyte count was not noticed throughout HD. Between 15 and 90 minutes after the start of HD, scarcely any circulating leukocytes were found in capillaries in the REC and some leukocytes were attached to the endothelial surface. Thereafter circulating leukocytes were seen again and detachment of leukocytes from the endothelial surface was observed. No leukocyte aggregation or embolization of aggregating leukocytes was noticed. This evidence suggests that leukopenia may be attributed to the transient shift of leukocytes to the marginal pool of the vessel lumen and this process may not be specific for the pulmonary vasculature, but may occur in the first capillary bed into which the blood passing through the HFAK flows.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
86.
87.
The purpose of this study was to investigate the effects on shear bond strength to resin after pure titanium (Ti) was exposed to plasma under different kinds of gas atmosphere. Polished Ti samples were treated using a plasma exposure apparatus in gas atmospheres of air, CO2, and C3F8. Surface analysis of Ti exposed to plasma was achieved through surface free energy and XPS measurements. The Ti sample was bonded with adhesive resin (4-META, MAC-10, HEMA, MDP, VBATDT) to a stainless steel piece. After which, shearing adhesion test was done. It was observed that plasma exposure in a specific gas atmosphere in regulated the bonding strength of titanium surface to resin. Based on the results of this study, we concluded that plasma exposure was a useful surface treatment method for dental practices. 相似文献
88.
Tamasaki H Sohmura T Teraoka F Yamamoto T Hirose Y Takahashi J Niwa H 《Dental materials journal》2005,24(1):76-82
A simple and novel method--in the form of solution spraying--was developed to fabricate biodegradable, porous poly(L-lactic acid) (PLLA) particulates for scaffold. PLLA pellets were dissolved in an organic solvent. Then, 5 % PLLA-dioxane solution was sprayed using an air-assisted atomizer with a nozzle diameter of 2.5 mm at an air flow rate of 15 L/min. After the sprayed solution solidified in liquid nitrogen, spherical particulates with median diameter of 225microm were obtained. Morphology of sprayed products could be altered by varying the fabrication conditions. When nozzle diameter was reduced to 1.5 mm, sprayed products became fibrous. When the concentration of PLLA-dioxane solution was increased, the diameter of particulates increased too. On the other hand, when air flow rate was increased, the diameter of particulates decreased. Likewise, solidification conditions also affected the morphology of sprayed products, such that they were either thin film-like or in particulate form. Based on the results of the present study, we concluded that PLLA particulates of varying morphologies could be obtained by adjusting the fabrication conditions. 相似文献
89.
Ando K Masumoto N Sakamoto M Teraoka K Suzuki T Kurihara T Abe S Tozaki M Fukuma E Hoshi K 《Breast care (Basel, Switzerland)》2011,6(6):471-473
BACKGROUND: Parotid gland metastasis in breast cancer is extremely rare, and only 14 cases have been reported between 1982 and 2010. CASE REPORT: A 67-year-old female patient was diagnosed with invasive lobular carcinoma of the left breast. Although clinical staging was T1N3M1 (stage IV), the tumor experienced a complete response to chemotherapy. We therefore performed a mastectomy followed by radiotherapy, and continued administration of trastuzumab. However, 11 months later, the patient complained of a swelling in the left parotid gland. Histology following a partial parotidectomy revealed a parotid gland metastasis from the breast. CONCLUSION: Treatment with capecitabine in addition to trastuzumab, which is one of the strategies applied in HER2-positive breast cancer, was effective in our patient. Analysis of the 14 cases of parotid gland metastasis from the breast reported between 1982 and 2010 revealed that the metastasis may occur not by direct lymphatic but by hematogenous spread. 相似文献
90.
Hisaharu Shikata Takuya Matumoto Hiroki Teraoka Masahiko Kaneko Mamoru Nakanishi Tadashi Yoshino 《International journal of hematology》2009,89(2):214-217
A 72-year-old man was diagnosed with essential thrombocythemia (ET) and was treated with hydroxyurea for approximately 5 years.
He was well until April 2007. In May 2007, a slight fall in hemoglobin levels was found. In June 2007, an upper endoscopy
performed to investigate the cause of anemia showed multiple polypoid lesions in the body of the stomach. A gastric biopsy
showed a diffuse infiltration of very immature cells. Several additional immunohistochemical staining showed that the cells
were positive for CD13, CD34, CD117, and HLA DR, but negative for myeloperoxidase, CD42b, glycophorin, B cell marker, T cell
marker, cytokeratin and desmin. We finally diagnosed the condition as myeloid sarcoma. Subsequently, the patient’s ET transformed
into acute myeloid leukemia. To our knowledge, this is an exceedingly rare event involving a patient with essential thrombocythemia. 相似文献