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41.
Anastazija Hvala Dušan Ferluga Tomaž Rott Tatjana Kobenter Mira Koselj-Kajtna Staša Kaplan-Pavlovčič 《Ultrastructural pathology》2013,37(4):295-299
Knowledge about the normal structure and pathology of interstitial capillary is limited. Splitting and multilayering of the basal membrane (BM), as a marker of chronic rejection, has been published in association with transplant glomerulopathy. The authors investigated the ultrastructural features of the interstitial capillary basal membrane in normal (15 biopsies) and in transplanted kidneys (27 biopsies from 21 patients), expressing transplant glomerulopathy (8 biopsies from 6 patients), acute tubulo-interstitial rejection (9 biopsies from 6 patients), and recurrent or de novo glomerulonephritis (10 biopsies from 8 patients). All biopsies were fixed in 1%OsO 4, embedded in Epon, and examined by electron microscope. Measurements of the interstitial capillary BM were made. The BM of interstitial capillary of intact kidney was a homogenous continuous structure, 88 nm in width on average. Thickening with diffuse multilayering of BM was most intensive in patients with transplant glomerulopathy, and much less intensive in patients with acute tubulointerstitial rejection and in patients with recurrent or de novo glomerulonephritis. These findings may provide the first information about the morphology of the normal basal lamina of interstitial capillary and support the diagnostic value of interstitial capillary changes in chronic rejection. 相似文献
42.
Tatjana A. Nazir 《Cognitive neuropsychology》2013,30(1):73-80
Introduction Due to structural characteristics of the visual pathways, stimuli that are presented in the right half of the visual field (RVF) are initially projected to the left cerebral hemisphere, while those presented in the left half of the visual field (LVF) are projected to the right cerebral hemisphere. This anatomical feature has frequently been taken to support the notion that the well-documented RVF advantage in recognising printed words is a reflection of functional differences between the two hemispheres; notably that of the dominance of the left hemisphere for processing language. Word stimuli that are sent straight to the left hemisphere are believed to profit from more efficient processing than those sent initially to the right hemisphere, because the latter stimuli must follow a longer and more noisy pathway before reaching the language-dominant hemisphere. In the work by Jordan, Patching, and Thomas (2003) the above notion is further developed to speculate that the point of entry of visual information into the cortex may determine the procedure that will underlie the ensuing word recognition process: "... the left hemisphere can process words by mapping orthographic information in parallel onto lexical entries whereas the right hemisphere has a more rudimentary process, that can only map orthographic information sequentially" (p. 50). 相似文献
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Boris Klempa Tatjana Avsic-Zupanc Jan Clement Tamara K. Dzagurova Heikki Henttonen Paul Heyman Ferenc Jakab Detlev H. Kruger Piet Maes Anna Papa Evgeniy A. Tkachenko Rainer G. Ulrich Olli Vapalahti Antti Vaheri 《Archives of virology》2013,158(3):521-529
Dobrava-Belgrade virus (DOBV) is a human pathogen that has evolved in, and is hosted by, mice of several species of the genus Apodemus. We propose a subdivision of the species Dobrava-Belgrade virus into four related genotypes – Dobrava, Kurkino, Saaremaa, and Sochi – that show characteristic differences in their phylogeny, specific host reservoirs, geographical distribution, and pathogenicity for humans. 相似文献
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Fabian Brunk Andreas Moritz Annika Nelde Tatjana Bilich Nicolas Casadei Sabine A. K. Fraschka Jonas S. Heitmann Sebastian Hörber Andreas Peter Hans-Georg Rammensee Harpreet Singh Juliane Walz Dominik Maurer Claudia Wagner 《European journal of immunology》2021,51(11):2651-2664
Both B cells and T cells are involved in an effective immune response to SARS-CoV-2, the disease-causing virus of COVID-19. While B cells—with the indispensable help of CD4+ T cells—are essential to generate neutralizing antibodies, T cells on their own have been recognized as another major player in effective anti-SARS-CoV-2 immunity. In this report, we provide insights into the characteristics of individual HLA-A*02:01- and HLA-A*24:02-restricted SARS-CoV-2-reactive TCRs, isolated from convalescent COVID-19 patients. We observed that SARS-CoV-2-reactive T-cell populations were clearly detectable in convalescent samples and that TCRs isolated from these T cell clones were highly functional upon ectopic re-expression. The SARS-CoV-2-reactive TCRs described in this report mediated potent TCR signaling in reporter assays with low nanomolar EC50 values. We further demonstrate that these SARS-CoV-2-reactive TCRs conferred powerful T-cell effector function to primary CD8+ T cells as evident by a robust anti-SARS-CoV-2 IFN-γ response and in vitro cytotoxicity. We also provide an example of a long-lasting anti-SARS-CoV-2 memory response by reisolation of one of the retrieved TCRs 5 months after initial sampling. Taken together, these findings contribute to a better understanding of anti-SARS-CoV-2 T-cell immunity and may contribute to paving the way toward immunotherapeutics approaches targeting SARS-CoV-2. 相似文献
46.
Sixten Krper Bernd Jahrsdrfer Victor M. Corman Jan Pilch Patrick Wuchter Rainer Blasczyk Rebecca Müller Torsten Tonn Tamam Bakchoul Richard Schfer David Juhl Tatjana Schwarz Nina Gdecke Thomas Burkhardt Michael Schmidt Thomas Appl Hermann Eichler Harald Klüter Christian Drosten Erhard Seifried Hubert Schrezenmeier 《Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie》2021,48(3):137
BackgroundConvalescent plasma is one of the treatment options for COVID-19 which is currently being investigated in many clinical trials. Understanding of donor and product characteristics is important for optimization of convalescent plasma.MethodsPatients who had recovered from COVID-19 were recruited as donors for COVID-19 convalescent plasma (CCP) for a randomized clinical trial of CCP for treatment of severe COVID-19 (CAPSID Trial). Titers of neutralizing antibodies were measured by a plaque-reduction neutralization test (PRNT). Correlation of antibody titers with host factors and evolution of neutralizing antibody titers over time in repeat donors were analysed.ResultsA series of 144 donors (41% females, 59% males; median age 40 years) underwent 319 plasmapheresis procedures providing a median collection volume of 850 mL and a mean number of 2.7 therapeutic units per plasmapheresis. The majority of donors had a mild or moderate course of COVID-19. The titers of neutralizing antibodies varied greatly between CCP donors (from <1:20 to >1:640). Donor factors (gender, age, ABO type, body weight) did not correlate significantly with the titer of neutralizing antibodies. We observed a significant positive correlation of neutralization titers with the number of reported COVID-19 symptoms and with the time from SARS-CoV-2 diagnosis to plasmapheresis. Neutralizing antibody levels were stable or increased over time in 58% of repeat CCP donors. Mean titers of neutralizing antibodies of first donation and last donation of repeat CCP donors did not differ significantly (1:86 at first compared to 1:87 at the last donation). There was a significant correlation of neutralizing antibodies measured by PRNT and anti-SARS-CoV-2 IgG and IgA antibodies which were measured by ELISA. CCP donations with an anti-SARS-CoV-2 IgG antibody content above the 25th percentile were substantially enriched for CCP donations with higher neutralizing antibody levels.ConclusionWe demonstrate the feasibility of collection of a large number of CCP products under a harmonized protocol for a randomized clinical trial. Titers of neutralizing antibodies were stable or increased over time in a subgroup of repeat donors. A history of higher number of COVID-19 symptoms and higher levels of anti-SARS-CoV-2 IgG and IgA antibodies in immunoassays can preselect donations with higher neutralizing capacity. 相似文献
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48.
Quantification of perfusion in murine myocardium: A retrospectively triggered T1‐based ASL method using model‐based reconstruction 下载免费PDF全文
49.
Early development of human lymphomas in a prostate cancer xenograft program using triple knock‐out Immunocompromised mice 下载免费PDF全文
50.
Transcranial Parenchymal Sonographic Findings in Patients With Cerebral Small Vessel Disease 下载免费PDF全文