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101.
M J Taphoorn W A de Vries-Knoppert H Ponssen J G Wolbers 《Journal of neurosurgery》1989,70(2):277-279
Malignant optic glioma in adulthood is a rare tumor that causes early loss of vision and nearly always leads to death within a year. A case history is presented illustrating the clinical and neuroradiological characteristics of the malignant optic glioma in adults. A review of the literature is given. 相似文献
102.
103.
Observations on the lesion site in the Miller Fisher syndrome: presentation of a case including CT and MRI 总被引:3,自引:0,他引:3
M. J. B. Taphoorn P. Lanting G. J. Hazenberg B. J. M. Uitdehaag M.C. Kaiser 《Acta neurologica Scandinavica》1989,80(2):167-169
Debate about the lesion site in the Miller Fisher syndrome is still going on. We studied a patient with features of the Miller Fisher syndrome in whom arguments for both central and peripheral nervous system dysfunction were found. 相似文献
104.
105.
van der Linden Sophie D. Rutten Geert-Jan M. Dirven Linda Taphoorn Martin J. B. Satoer Djaina D. Dirven Clemens M. F. Sitskoorn Margriet M. Gehring Karin 《Journal of neuro-oncology》2021,154(3):315-326
Journal of Neuro-Oncology - Evidence-based cognitive rehabilitation programs for brain tumor patients are not widely available, despite the high need. We aimed to evaluate the effects of a... 相似文献
106.
Habets Esther J. J. Hendriks Eef J. Taphoorn Martin J. B. Douw Linda Zwinderman Aeilko H. Vandertop W. Peter Barkhof Frederik De Witt Hamer Philip C. Klein Martin 《Journal of neuro-oncology》2019,143(3):573-581
Journal of Neuro-Oncology - To evaluate the pharmacokinetics and efficacy of imatinib in patients with recurrent oligodendroglial tumors. Patients with progressive WHO grade II-III recurrent tumors... 相似文献
107.
J. A. F. Koekkoek L. Dirven J. C. Reijneveld E. M. Sizoo H. R. W. Pasman T. J. Postma L. Deliens R. Grant S. McNamara W. Grisold E. Medicus G. Stockhammer S. Oberndorfer B. Flechl C. Marosi M. J. B. Taphoorn J. J. Heimans 《Journal of neuro-oncology》2014,117(2):303-310
Brain metastases treated with stereotactic radiosurgery may show delayed enlargement on post-treatment imaging that is of ambiguous etiology. Histopathologic interpretation of brain specimens is often challenging due to the presence of significant radiation effects admixed with irradiated residual tumor of indeterminate viability. The purpose of this study was to assess the impact of histologic findings on clinical outcomes following resection of these lesions. Between 2004 and 2010, 690 patients with brain metastases were enrolled in a prospective gamma knife data repository, and lesions requiring excision were identified. Tissue specimens were divided into four groups based on the ratio of treatment related inflammatory changes (TRIC) to tumor cells, and subsequently patient outcomes were assessed. Of 2,583 metastases treated, 36 were excised due to symptomatic enlargement. Only TRIC, without residual evidence of tumor, was seen in 36 % (13/36) of specimens. Resection of these lesions resulted in 100 % local control in follow-up. Of the remaining 23 lesions that contained any viable-appearing tumor within the resected specimen, 8 recurred after resection. Lesions that enlarged in the first 6 months were more likely to contain higher amounts of residual tumor cells. Patients with even <2 % tumors cells on excision had significantly worse local control (75 vs. 100 %, p = 0.024) and survival (HR 0.27, p = 0.029) compared with those patients with exclusively TRIC. In summary, our findings underscore the importance of surgically obtaining tissue in a method that facilitates complete lesional interpretive histology in order to accurately guide ongoing patient management. 相似文献
108.
Eefje M. Sizoo Martin J.B. Taphoorn Bernard Uitdehaag Jan J. Heimans Luc Deliens Jaap C. Reijneveld H. Roeline W. Pasman 《The oncologist》2013,18(2):198-203
Background.
In the end-of-life (EOL) phase, high-grade glioma (HGG) patients have a high symptom burden and often lose independence because of physical and cognitive dysfunction. This might affect the patient''s personal dignity. We aimed to (a) assess the proportion of HGG patients dying with dignity as perceived by their relatives and (b) identify disease and care factors correlated with dying with dignity in HGG patients.Methods.
We approached relatives of a cohort of 155 deceased HGG patients for the study. Participants completed a questionnaire concerning the EOL phase of the patient, covering several subthemes: (a) symptoms and signs, (b) health-related quality of life, (c) decision making, (d) place and quality of EOL care, and (e) dying with dignity.Results.
Relatives of 81 patients participated and 75% indicated that the patient died with dignity. These patients had fewer communication deficits, experienced fewer transitions between health care settings in the EOL phase, and more frequently died at their preferred place of death. Relatives were more satisfied with the physician providing EOL care and reported that the physician adequately explained treatment options. Multivariate analysis identified satisfaction with the physician, the ability to communicate, and the absence of transitions between settings as most predictive of a dignified death.Conclusions.
Physicians caring for HGG patients in the EOL phase should timely focus on explaining possible treatment options, because patients experience communication deficits toward death. Physicians should strive to allow patients to die at their preferred place and avoid transitions during the last month of life. 相似文献109.
Florien W. Boele Linda Douw Marjolein de Groot Hinke F. van Thuijl Wilmy Cleijne Jan J. Heimans Martin J.B. Taphoorn Jaap C. Reijneveld Martin Klein 《Neuro-oncology》2013,15(10):1420-1428