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71.
Mitogenic activity of lipopolysaccharide (LPS), concanavalin A (Con A), phorbol myristate acetate (PMA) and phytohemagglutinin (PHA) were investigated using spleen cells prepared from C57BL/6 mice orally pretreated with one of five kampohozai extracts (Shosaikoto, Daisaikoto, Hochuekkito, Juzendaihoto and Tokishakuyakusan). Shosaikoto and Daisaikoto elevated the mitogenic activity of LPS and reduced those of Con A. The mitogenic activities of PMA and PHA were elevated by low doses of Shosaikoto and Daisaikoto and suppressed by high doses. Juzendaihoto and Tokishakuyakusan showed no effect on the mitogenic activity of LPS and Con A, but increased those of PMA and PHA. Hochuekkito increased the mitogenic activity of LPS, Con A, PMA and PHA. In the absence of mitogens, these five kampohozais showed no mitogenic activity. These results indicate that the kampohozais used in this experiment appear to possess the immunomodulating or immunostimulating activities that might be expected from clinical experiences in Japan and China. 相似文献
72.
Ichiki M Kawasaki M Takayama K Ninomiya K Kuba M Iwami F Miyazaki N Oishi K Takeo S Aizawa H Nakanishi Y 《Cancer chemotherapy and pharmacology》2006,58(3):368-373
Purpose: This multicenter phase II study was conducted to investigate the efficacy and safety of carboplatin in combination with paclitaxel administered according to a biweekly schedule as a first-line chemotherapy for advanced non-small-cell lung cancer (NSCLC). Patients and methods: Eligibility criteria included histologically or cytologically confirmed NSCLC (stage IIIb or IV), no prior treatment, and measurable or evaluable disease. Paclitaxel (140 mg/m2) was administered intravenously on day 1, in combination with carboplatin at an area under the concentration time curve (AUC) of 3, every 2 weeks. Results: Seventy-four patients (45 men) with a median age of 62 years (range 40–74) and a median ECOG performance status of 1 (range 0–2) were enrolled. The response rate was 35.1% [95% confidence interval (CI): 24.4–47.1%], with 26 partial responses. The median survival was 357 days, and the median time to progression was 218 days. Toxicity was generally mild; National Cancer Institute-Common Toxicity Criteria (NCI-CTC) grades 3 and 4 neutropenia was observeded in 50.0% of the patients, and grades 3 and 4 nausea/vomiting in 4.1%. Conclusions: Biweekly carboplatin combined with paclitaxel demonstrated anti-tumor activity in advanced NSCLC, with response and survival rates similar to those of carboplatin combined with paclitaxel administered every 3 weeks but with a more favorable toxicity profile, and the present data indicate that the regimen is suitable for use on an outpatient basis. 相似文献
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Crude habu venom decreased coronary perfusion pressure and produced a small increase in myocardial tension of isolated and perfused rat hearts. Indomethacin infusion depressed the fall in perfusion pressure caused by the venom, without affecting the increase in tension. Heated venom decreased perfusion pressure, but did not increase myocardial tension. These results suggest that crude habu venom has coronary vasodilating and positive inotropic effects, possibly through actions of a phospholipase A2 and a heat-labile component, respectively. 相似文献
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77.
Mai Kikumoto Shuichiro Neshige Takeo Shishido Hiroki Ueno Shiro Aoki Koji Iida Hirofumi Maruyama 《Internal medicine (Tokyo, Japan)》2022,61(8):1237
We evaluated a 39-year-old pregnant woman with right temporal lobe epilepsy. During the second trimester, seizure deterioration was responsive to an increased daily dose of levetiracetam (LEV). However, immediately after delivery, new non-habitual seizures emerged along with a sharply increased LEV concentration. The frequency of habitual seizures also slightly increased. The non-habitual seizures completely disappeared, and the frequency of the habitual seizures improved to the baseline level after the LEV dosage was reduced. Thus, a paradoxical effect of an increased LEV blood concentration was assumed to be a potential cause of these events. Peripartum pharmacokinetic fluctuations in LEV levels should be monitored carefully. 相似文献
78.
Kyohei Takahashi Yukihiro Tohdoh Takeo Matsubayashi Vladimír Jellúš Katsuya Maruyama 《Clinical imaging》2012,36(6):816-820
Longitudinal relaxation time (T1) determined by 3.0-T magnetic resonance imaging of the tibialis anterior and extensor digitorum longus muscles increased gradually with muscle fatigue caused by three 120-s periods of repeated ankle dorsiflexion separated by 5-min rest periods. T1 values decreased in the recovery period, although they remained higher than the preexercise values. T1 values for the soleus muscle were unchanged throughout the experiment. Results suggest that muscle T1 values increase with increasing muscle fatigue. 相似文献
79.
Md. Rezwan Miah Takeo Ohsaka 《Journal of electroanalytical chemistry (Lausanne, Switzerland)》2009,633(1):71-77
Oxygen reduction reaction (ORR) was investigated using polycrystalline gold (Au (poly)) electrode modified with chemisorbed iodine (I(ads)) submonolayer (sub I(ads)) in O2-saturated 0.1 M KOH solution. The sub I(ads) was tailored by potential-dependent partial reductive desorption of I(ads) from its full monolayer. The Au (1 1 1) facet of the Au (poly) electrode was considered to remain bared at the sub I(ads)/Au (poly) electrode. The interesting finding of the present study is that (unlike the bare Au (poly) electrode) the sub I(ads)/Au (poly) electrode exhibited a quasi-reversible two-electron reduction of O2 in alkaline media. The probable origin of the observed quasi-reversible behavior of the ORR is discussed. Experimental investigations were performed using cyclic and steady-state voltammetric, amperometric and coulometric techniques. 相似文献
80.
Leontiou CA Gueorguiev M van der Spuy J Quinton R Lolli F Hassan S Chahal HS Igreja SC Jordan S Rowe J Stolbrink M Christian HC Wray J Bishop-Bailey D Berney DM Wass JA Popovic V Ribeiro-Oliveira A Gadelha MR Monson JP Akker SA Davis JR Clayton RN Yoshimoto K Iwata T Matsuno A Eguchi K Musat M Flanagan D Peters G Bolger GB Chapple JP Frohman LA Grossman AB Korbonits M 《The Journal of clinical endocrinology and metabolism》2008,93(6):2390-2401