全文获取类型
收费全文 | 1216篇 |
免费 | 67篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 51篇 |
妇产科学 | 14篇 |
基础医学 | 185篇 |
口腔科学 | 17篇 |
临床医学 | 78篇 |
内科学 | 363篇 |
皮肤病学 | 40篇 |
神经病学 | 80篇 |
特种医学 | 38篇 |
外科学 | 199篇 |
综合类 | 5篇 |
预防医学 | 29篇 |
眼科学 | 7篇 |
药学 | 82篇 |
中国医学 | 1篇 |
肿瘤学 | 91篇 |
出版年
2023年 | 14篇 |
2022年 | 20篇 |
2021年 | 44篇 |
2020年 | 23篇 |
2019年 | 32篇 |
2018年 | 45篇 |
2017年 | 30篇 |
2016年 | 36篇 |
2015年 | 31篇 |
2014年 | 30篇 |
2013年 | 48篇 |
2012年 | 64篇 |
2011年 | 65篇 |
2010年 | 31篇 |
2009年 | 28篇 |
2008年 | 46篇 |
2007年 | 51篇 |
2006年 | 65篇 |
2005年 | 48篇 |
2004年 | 59篇 |
2003年 | 41篇 |
2002年 | 36篇 |
2001年 | 30篇 |
2000年 | 35篇 |
1999年 | 19篇 |
1998年 | 18篇 |
1997年 | 14篇 |
1996年 | 13篇 |
1995年 | 9篇 |
1994年 | 13篇 |
1993年 | 12篇 |
1992年 | 21篇 |
1991年 | 28篇 |
1990年 | 19篇 |
1989年 | 22篇 |
1988年 | 16篇 |
1987年 | 13篇 |
1986年 | 24篇 |
1985年 | 24篇 |
1984年 | 11篇 |
1983年 | 14篇 |
1982年 | 3篇 |
1980年 | 6篇 |
1979年 | 4篇 |
1978年 | 4篇 |
1977年 | 4篇 |
1969年 | 4篇 |
1968年 | 3篇 |
1967年 | 2篇 |
1966年 | 4篇 |
排序方式: 共有1288条查询结果,搜索用时 15 毫秒
21.
Concentrations of fumes, ozone (O3), carbon monoxide (CO), nitric oxide (NO), manganese (Mn) and total and hexavalent chromium (Cr) as well as size distribution of fumes were measured at a point corresponding to the welder's breathing zone during CO2-arc welding, using a welding robot and three kinds of wires. Concentrations of fumes, O3, CO, Mn and total-Cr were found to exceed their corresponding occupational exposure limit (OEL) values, while the concentrations of NO and Cr(VI) were below those OEL levels. Airborne concentration of Mn exceeded its OEL value, and the Mn content was 8 times higher in welding fumes than in the wire. Using an additive equation of OEL and exposure concentration of each hazardous component, health risk in welders with combined exposure to welding fumes and gases was assessed as 18.6 to 46.0 times of OEL, which exceeded the unity. This finding suggests that effective protection of welders from the exposure can be attained by use of the supplied-air respirator or combined use of a dust respirator and a local exhaust system. 相似文献
22.
J. Takaya R. Ishihara M. Kino H. Higashino Y. Kobayashi 《European journal of pediatrics》1998,157(7):544-546
Adrenal enlargement was followed by serial ultrasonography in an infant with congenital lipoid adrenal hyperplasia (lipoid
CAH) from day 12 until 2 years and 4 months of age, when they were no longer detectable. Contrary to other types of CAH in
which the configuration changes soon after replacement therapy, this infant with lipoid CAH showed persistent adrenal cortex
enlargement due to massive accumulation of lipids and cholesterol resulting in a damaged glandular cyto-architecture.
Conclusion ultrasonographically persistent enlargement of the adrenals after replacement therapy is suggestive of the lipoid form of
CAH.
Received: 3 June 1997 / Accepted in revised form: 19 December 1997 相似文献
23.
24.
Masashi Ogawa Maho Morikawa Masaki Kobatake Taku Murakami Yuki Yamamoto Rikiya Watanabe Katsumi Yamada Katsuhito Nishiyama Yoshiro Yasutomo Kenta Hara 《Internal medicine (Tokyo, Japan)》2022,61(16):2489
An 82-year-old man was transferred to our hospital due to impaired consciousness. His albumin-corrected calcium level was 14.2 mg/dL, intact parathyroid hormone (PTH) and PTH-related protein levels were reduced, and his 1,25-dihydroxyvitamin D [1,25(OH)2VitD] level was elevated at 71.5 pg/mL. Computed tomography revealed masses on the bilateral ribs. The mass on the rib was biopsied and diagnosed as diffuse large B-cell lymphoma (DLBCL). Immunostaining of the biopsy sample with the anti-CYP27B1 antibody revealed the ectopic expression of 1α-hydroxylase in the lesion. We herein report a rare case of hypercalcemia induced by the overproduction of 1,25(OH)2VitD in DLBCL ectopically expressing 1α-hydroxylase. 相似文献
25.
Andika Pramudya Wardana Muhammad Ikhlas Abdjan Nanik Siti Aminah Mochamad Zakki Fahmi Imam Siswanto Alfinda Novi Kristanti Mirza Ardella Saputra Yoshiaki Takaya 《RSC advances》2022,12(46):29884
We report a natural product compound isolated from Syzygium polycephalum known as 3,4,3′-tri-O-methylellagic acid (T-EA) as a candidate drug for cancer treatment. The characterization of the isolated T-EA compound was carried out using various spectroscopic methods. The in vitro evaluation showcased the inhibition activity of T-EA towards the T47D and HeLa cell lines with EC50 values of 55.35 ± 6.28 μg mL−1 and 12.57 ± 2.22 μg mL−1, respectively. Meanwhile, the in silico evaluation aimed to understand the interaction of T-EA with enzymes responsible for cancer regulation at the molecular level by targeting the hindrance of cyclin-dependent kinase 9 (CDK9) and sirtuin 1 (SIRT1) enzymes. T-EA showed a binding free energy towards the SIRT1 protein of ΔGbind (MM-GBSA): −30.98 ± 0.25 kcal mol−1 and ΔGbind (MM-PBSA): −24.07 ± 0.30 kcal mol−1, while that of CDK9 was ΔGbind (MM-GBSA): −29.50 ± 0.22 kcal mol−1 and ΔGbind (MM-PBSA): −25.87 ± 0.40 kcal mol−1. The obtained results from this research could be considered as important information on 3,4,3′-tri-O-methylellagic acid as a drug to treat cervical and breast cancers.We report a natural product compound isolated from Syzygium polycephalum known as 3,4,3′-tri-O-methylellagic acid (T-EA) as a candidate drug for cancer treatment using in vitro and in silico approaches. 相似文献
26.
Takehiko Onoki Takaya Metoki Shinya Iwasawa Kengo Kawano Masato Kimura Shigeo Kure Chiharu Ota 《Internal medicine (Tokyo, Japan)》2022,61(23):3525
Kawasaki disease (KD) is a systemic vasculitis syndrome that mostly affects children under 4 years old. Among the reported KD cases, only 1% were over 10 years old. We herein report 2 cases of adult-onset KD (AKD) in 19- and 17-year-old boys diagnosed with a persistent fever and cervical lymphadenitis. Both patients showed cardiac complications, such as coronary artery dilation and myocarditis. Repeated intravenous immunoglobulin therapy was effective in the 19-year-old, while plasma exchange therapy was needed for the 17-year-old, with no sequelae noted at discharge. KD should be considered as a differential diagnosis for persistent fever in adults. 相似文献
27.
28.
29.
Masaki Y Sumiyoshi M Suwa S Ohta H Matsunaga E Tamura H Takaya N Mineda Y Kojima S Nakata Y 《International heart journal》2005,46(2):323-326
Dissection of the sinus of Valsalva is an extremely rare accident during percutaneous coronary intervention (PCI), but it can lead to serious complications such as dissection of the ascending aorta. We experienced a localized dissection of the right coronary cusp without coronary artery involvement that was induced by a guiding catheter during PCI in a patient with acute myocardial infarction. The localized dissection showed pooling of the contrast medium in the acute phase, but it subsided spontaneously after 12 days without any sequelae. Manipulation of the guiding catheter should be performed with great caution not only in the coronary artery but also in the sinus of Valsalva. 相似文献
30.
Alterations of plasma ghrelin levels in rats with lipopolysaccharide-induced wasting syndrome and effects of ghrelin treatment on the syndrome 总被引:5,自引:0,他引:5
Hataya Y Akamizu T Hosoda H Kanamoto N Moriyama K Kangawa K Takaya K Nakao K 《Endocrinology》2003,144(12):5365-5371
Ghrelin not only strongly stimulates GH secretion, but is also involved in energy homeostasis by stimulating food intake and promoting adiposity through a GH-independent mechanism. These effects of ghrelin may play an important role in the pathophysiology of inflammatory wasting syndrome, in which both the somatotropic axis and energy balance are altered. In this study we investigated plasma ghrelin concentrations after lipopolysaccharide (LPS) administration to rats, a model of the wasting syndrome and critical illness. In addition, the therapeutic potential of the antiwasting effects of ghrelin was explored using LPS-injected rats. A single LPS injection suppressed plasma ghrelin levels 6 and 12 h later. Maximal reduction was observed 12 h after LPS injection, in a dose-dependent manner. In contrast, plasma ghrelin levels were elevated after repeated LPS injections on d 2 and 5. Peripheral administration of ghrelin twice daily (10 nmol/rat) for 5 d increased body weight gain in repeated LPS-injected rats. Furthermore, both adipose tissue weight and plasma leptin concentrations were increased after ghrelin administration in these rats. In conclusion, plasma ghrelin levels are altered in LPS-injected rats, and ghrelin treatment may provide a new therapeutic approach to the wasting syndrome and critical illness. 相似文献