全文获取类型
收费全文 | 156335篇 |
免费 | 32801篇 |
国内免费 | 2446篇 |
专业分类
耳鼻咽喉 | 5235篇 |
儿科学 | 5506篇 |
妇产科学 | 2433篇 |
基础医学 | 3986篇 |
口腔科学 | 1583篇 |
临床医学 | 26966篇 |
内科学 | 49387篇 |
皮肤病学 | 7466篇 |
神经病学 | 15282篇 |
特种医学 | 6716篇 |
外科学 | 42111篇 |
综合类 | 247篇 |
现状与发展 | 72篇 |
一般理论 | 1篇 |
预防医学 | 7161篇 |
眼科学 | 3402篇 |
药学 | 1341篇 |
中国医学 | 46篇 |
肿瘤学 | 12641篇 |
出版年
2024年 | 516篇 |
2023年 | 4820篇 |
2022年 | 1237篇 |
2021年 | 3179篇 |
2020年 | 6092篇 |
2019年 | 2275篇 |
2018年 | 7501篇 |
2017年 | 7433篇 |
2016年 | 8557篇 |
2015年 | 8515篇 |
2014年 | 15630篇 |
2013年 | 15815篇 |
2012年 | 5786篇 |
2011年 | 5869篇 |
2010年 | 10548篇 |
2009年 | 14404篇 |
2008年 | 6097篇 |
2007年 | 4390篇 |
2006年 | 6848篇 |
2005年 | 4224篇 |
2004年 | 3475篇 |
2003年 | 2480篇 |
2002年 | 2600篇 |
2001年 | 3913篇 |
2000年 | 3131篇 |
1999年 | 3329篇 |
1998年 | 3782篇 |
1997年 | 3566篇 |
1996年 | 3457篇 |
1995年 | 3300篇 |
1994年 | 2038篇 |
1993年 | 1654篇 |
1992年 | 1482篇 |
1991年 | 1487篇 |
1990年 | 1144篇 |
1989年 | 1249篇 |
1988年 | 1109篇 |
1987年 | 929篇 |
1986年 | 942篇 |
1985年 | 773篇 |
1984年 | 595篇 |
1983年 | 558篇 |
1982年 | 544篇 |
1981年 | 420篇 |
1980年 | 385篇 |
1979年 | 334篇 |
1978年 | 346篇 |
1977年 | 419篇 |
1975年 | 297篇 |
1972年 | 320篇 |
排序方式: 共有10000条查询结果,搜索用时 7 毫秒
991.
Alysa R. Herman MD Klaus J. Busam MD Robert A. Greenberg MD Kishwer S. Nehal MD 《Dermatologic surgery》2003,29(4):436-439
BACKGROUND: Basal cell carcinoma shows a wide spectrum of clinical and histologic appearances. A distinct tumor variant with follicular infundibulocystic differentiation is recognized, and there are only a few reports on its clinical presentation and management. OBJECTIVE: To report a case of multiple infundibulocystic basal cell carcinomas with a unique unilateral presentation. METHODS: A clinical history was obtained. Photographs were taken, and punch biopsies were performed. RESULTS: An 83-year-old Caucasian female presented with multiple unilateral, asymptomatic, skin-colored, dome-shaped papules around the right mouth for 11 years without apparent change. Punch biopsies revealed findings typical of infundibulocystic basal cell carcinoma. CONCLUSIONS: A patient with clinically indolent multiple unilateral infundibulocystic basal cell carcinomas is described. Given the location of these multiple lesions, standard treatment modalities for basal cell carcinomas would have significant cosmetic and functional implications. A management approach with clinical follow-up and surgical intervention only for changing lesions is discussed. 相似文献
992.
β2-glycoprotein-I (β2GPI) is a phospholipid-binding plasma protein that consists of five homologous domains. Domain V is distinguished from others by bearing a positively charged lysine cluster and hydrophobic extra C-terminal loop. β2GPI has been known as a natural anticoagulant regulator. β2GPI exerts anticoagulant activity by inhibition of phospholipid-dependent coagulation reactions such as prothrombinase, tenase, and factor XII activation. It also binds factor XI and inhibits its activation. On the other hand, β2GPI inhibits anticoagulant activity of activated protein C. According to the data from knockout mice, β2GPI may contribute to thrombin generation in vivo. Phospholipid-bound β2GPI is one of the major target antigens for antiphospholipid antibodies present in patients with antiphospholipid syndrome (APS). Binding of pathogenic anti-β2GPI antibodies increases the affinity of β2GPI to the cell surface and disrupts the coagulation/fibrinolysis balance on the cell surface. These pathogenic antibodies activate endothelial cells via signal transduction events in the presence of β2GPI. Impaired fibrinolysis has been reported in patients with APS. Using a newly developed chromogenic assay, we demonstrated lower activity of intrinsic fibrinolysis in euglobulin fractions from APS patients. Addition of monoclonal anti-β2GPI antibodies with β2GPI also decreased fibrinolytic activity in this assay system. β2GPI is proteolytically cleaved by plasmin in domain V (nicked β2GPI) and becomes unable to bind to phospholipids, reducing antigenicity against antiphospholipid antibodies. This cleavage occurs in patients with increased fibrinolysis turnover. Nicked β2GPI binds to plasminogen and suppresses plasmin generation in the presence of fibrin, plasminogen, and tissue plasminogen activator (tPA). Thus, nicked β2GPI plays a role in the extrinsic fibrinolysis via a negative feedback pathway loop. 相似文献
993.
994.
995.
996.
997.
998.
Walter Daghino MD Luigi Milano MD Sergio Ronco MD Giorgio Ronco MD Angelo Dettoni MD Massimo Cartesegna MD 《The Journal of foot and ankle surgery》2003,42(3):155-160
This article is a retrospective study comparing the efficacy of Regnauld arthroplasty to first ray osteotomies for the treatment of hallux valgus. One hundred consecutive cases of Regnauld arthroplasties were compared with 100 consecutive first ray osteotomies. One hundred fourty-one patients were available for follow-up, and based on clinical/radiographic examinations, 72 were treated with the osteotomy protocol (group A) and 69 with Regnauld arthroplasty (group B). Age at surgery, clinical symptoms, and preoperative radiologic findings were similar for the 2 groups; there was a preponderance of female patients (90%). The average follow-up was 49 months in group A and 51 months in group B. Clinical evaluation showed in the osteotomy group a more stable correction (79% v 49%), greater pain reduction (measured in a visual analog scale from 0 = pain free to 10 = deep intolerable pain), increased residual articular excursion of the first metatarsophalangeal joint (27 degrees of active dorsiflexion from neutral position v 8 degrees ), and less presence of central metatarsalgia (15% v 34%) (P <.05). The radiographic evaluation expressed more stable correction values in group A for the following parameters: joint preservation, sesamoid position, intermetatarsal angle (7 degrees v 12 degrees ), abduction angle of the hallux (14 degrees v 20 degrees ), and proximal articular set angle (8 degrees v 18 degrees ) (P <.05). 相似文献
999.
Kees-Peter De Roos MD Fred H.M. Nieman PHD H.A. Martino Neumann MD PHD 《Dermatologic surgery》2003,29(3):221-226
BACKGROUND: Although no randomized controlled trial has assessed the effects of either compression sclerotherapy or ambulatory phlebectomy, both techniques are used to treat varicose veins worldwide. We performed a randomized controlled trial to compare recurrence rates of varicose veins and complications after compression sclerotherapy and ambulatory phlebectomy. METHODS: From September 1996 to October 1998, we randomly allocated 49 legs to compression sclerotherapy and 49 legs to ambulatory phlebectomy. Our primary outcome parameters were as follows: recurrence rates at 1 and 2 years and complications related to therapy. Eighty-two patients were included, of whom 16 were included with both of their legs. The number of treated legs was therefore 98, but two patients were lost to follow-up. RESULTS: One year recurrence amounted to 1 out of 48 for phlebectomy and 12 out of 48 for compression sclerotherapy (P<0.001); at 2 years, six additional recurrences were found, but then solely for compression sclerotherapy (P<0.001). Significant differences in complications occurring more in phlebectomy than in compression sclerotherapy therapy were blisters, teleangiectatic matting, scar formation, and bruising from bandaging. CONCLUSION: Our results show that ambulatory phlebectomy is an effective therapy for varicose veins of the leg. Recurrence rates are significantly lower than for compression sclerotherapy therapy. If varicose veins persist 4 weeks after compression sclerotherapy, it can be argued that to reduce the risk of future recurrence ambulatory phlebectomy should be considered as the better treatment option. 相似文献
1000.