全文获取类型
收费全文 | 9617篇 |
免费 | 444篇 |
国内免费 | 54篇 |
专业分类
耳鼻咽喉 | 58篇 |
儿科学 | 166篇 |
妇产科学 | 93篇 |
基础医学 | 1186篇 |
口腔科学 | 208篇 |
临床医学 | 630篇 |
内科学 | 2551篇 |
皮肤病学 | 130篇 |
神经病学 | 826篇 |
特种医学 | 421篇 |
外国民族医学 | 1篇 |
外科学 | 1547篇 |
综合类 | 34篇 |
预防医学 | 207篇 |
眼科学 | 134篇 |
药学 | 693篇 |
中国医学 | 15篇 |
肿瘤学 | 1215篇 |
出版年
2023年 | 60篇 |
2022年 | 125篇 |
2021年 | 215篇 |
2020年 | 132篇 |
2019年 | 128篇 |
2018年 | 210篇 |
2017年 | 148篇 |
2016年 | 198篇 |
2015年 | 221篇 |
2014年 | 250篇 |
2013年 | 359篇 |
2012年 | 538篇 |
2011年 | 470篇 |
2010年 | 281篇 |
2009年 | 259篇 |
2008年 | 469篇 |
2007年 | 471篇 |
2006年 | 481篇 |
2005年 | 457篇 |
2004年 | 468篇 |
2003年 | 447篇 |
2002年 | 474篇 |
2001年 | 326篇 |
2000年 | 245篇 |
1999年 | 256篇 |
1998年 | 123篇 |
1997年 | 102篇 |
1996年 | 84篇 |
1995年 | 84篇 |
1994年 | 85篇 |
1993年 | 70篇 |
1992年 | 168篇 |
1991年 | 159篇 |
1990年 | 160篇 |
1989年 | 157篇 |
1988年 | 132篇 |
1987年 | 144篇 |
1986年 | 141篇 |
1985年 | 95篇 |
1984年 | 84篇 |
1983年 | 60篇 |
1982年 | 30篇 |
1980年 | 34篇 |
1979年 | 65篇 |
1978年 | 40篇 |
1977年 | 42篇 |
1972年 | 29篇 |
1971年 | 37篇 |
1969年 | 34篇 |
1968年 | 35篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
21.
Yamamoto Kazuhiko; Nakajima Akira; Eimoto Hiroyuki; Tsutsumi Masahiro; Maruyama Hiroshi; Denda Ayumi; Nii Hiroaki; Mori Yukio; Konishi Yoichi 《Carcinogenesis》1989,10(9):1607-1611
The carcinogenic activity of endogenously synthesized N-nitrosobis(2-hydroxypropyl)amine(BHP) was investigated in male Wistar rats administered bis(2-hydroxypropyl)amine(BHPA) mixed in powder diet at a concentration of 1%, and sodiumnitrite (SN) dissolved in distilled water at concentrationsof 0.15 and 0.3%, for 94 weeks. Urinary excretion of BHP wasdetected in rats given 1% BHPA and 0.3% SN but not in the groupsreceiving either of these precursors alone. Nasal cavity, lung,esophagus, liver and urinary bladder tumors were found in animalstreated with combinations of 1% BHPA and 0.15 or 0.3% SN, suggestingthat the target organs of the endogenously synthesized BHP aresimilar to those affected when the carcinogen is administeredexogenously. The incidences of nasal cavity and lung tumorsreached 74 and 58% in rats given 1% BHPA and 0.3% SN, respectively.Tumors at sites other than target organs were only found atlevels similar to those previously reported for spontaneoustumors in male Wistars. The present results clearly indicatedthe tumor inducibility of a nhrosatable amine, BHA, throughan endogenous nitrosation by feeding to rats in conjunctionwith nitrite, and provide further suggestive evidence that endogenousnitrosations of environmental nitrosatable amines can be a potentialrisk factor in human cancer development. 相似文献
22.
23.
24.
Michiyo Maruyama Shinichi Sato Tetsuya Tsuchida Kiyoshi Toda 《The Journal of dermatology》1994,21(4):280-282
We report here an unusual case of fibrous histiocytoma in which an area of xanthogranuloma was observed histologically. Our case suggests that adult xanthogranuloma is a variant of fibrous histiocytoma. 相似文献
25.
We identified the possible endogenous factor effective to modulate the binding of [3H]-labeled excitatory amino acid agonists and antagonists in the 100,000 x g supernatant of Triton X-100 (0.01%)-treated cell membranes from frog spinal cords. The factor inhibited the binding of [3H]glutamate to Triton X-100-treated cell membranes, to which the binding capacity of [3H]glutamate increased much more than that to intact cell membranes. The binding capacities of [3H]AMPA (an AMPA type agonist) and [3H]CPP (an NMDA type antagonist) to cell membranes remained low by Triton treatment, but they were enhanced significantly by the addition of the factor. The effect of the factor on the [3H]kainate binding was hardly observable. The factor may provide key information on receptor structures and the classification of receptor types concerning excitatory amino acids in the mammalian central nervous system. 相似文献
26.
Takanori Suzuki Kohei Kurokama Hidetoshi Yamanaka Liong Men Long Norio Daikuzono 《Lasers in surgery and medicine》1994,14(1):71-82
Prostatectomy by transurethral balloon Laserthermia (PROSTA-LASE?) was performed in a canine model. This balloon device monitored by transrectal ultrasound can cylindrically irradiate with a laser beam. The treatment was performed in 8 canines using 15 watts for 20 minutes at 60°C at a 5 mm depth of the prostate from the urethral surface. Immediately following the laser therapy, an area of coagulation necrosis was observed around the urethra to a depth of 4–5 mm from the surface. After 1 week, cavitation formation was seen in 3 or 4 canines by ultrasound, and the urethral reepithelialization was shown in 1 of 2 canines. After 2 weeks, cavitation formation was observed in both canines, and the urethra was completely reepithelialized in one canine. There was no tissue damage in the bladder neck of urethral sphincter and no urinary incontinence in any animal. This system is thought to be simple and, satisfactorily performed, is an effective transurethral prostatectomy. © 1994 Wiley-Liss, Inc. 相似文献
27.
I N Maruyama H I Maruyama S Brenner 《Proceedings of the National Academy of Sciences of the United States of America》1994,91(17):8273-8277
This work describes a lambda phage expression system, lambda foo, that produces foreign proteins fused to the surface of the virus particle. The lambda foo vector has multiple cloning sites for the insertion of a foreign DNA fragment and color selection for recombinants. Foreign proteins are fused to the C terminus of a truncated phage tail protein, pV, by a peptide linker. Conditional chain termination allows the assembly and fusion of multisubunit proteins. We have attached the complete Escherichia coli beta-galactosidase and the plant Bauhinia purpurea agglutinin by cloning their genes into the vector. The constructs express functionally active proteins on the phage particle surface and have been purified by affinity chromatography with an antibody for beta-galactosidase and a mucin as a ligand for Bauhinia purpurea agglutinin. 相似文献
28.
A vascularized rib strut based on the anterior intercostal branch of the internal mammary artery was applied to provide rigid internal fixation of the chest wall after correction of pectus excavatum. The procedure is simple and has substantial advantages when compared with techniques using metallic struts or nonvascularized free rib grafts. 相似文献
29.
Yoshiyuki Kaneko Tomohiro Nakayama Kosuke Saito Akihiko Morita Ichiro Sato Aya Maruyama Masayoshi Soma Teruyuki Takahashi Naoyuki Sato 《Hypertension research》2006,29(9):665-671
The risk of cerebral infarction (CI) in an individual is dependent on the interplay between genetic risk factors and environmental influences. Binding of thromboxane A2 (TXA2) to its receptor (TP) modulates thrombosis/hemostasis and plays a significant role in the pathogenesis of CI. The aim of the present study was to investigate the relationship between human TP gene single nucleotide polymorphisms (SNPs) and haplotypes and CI in a Japanese population. A genetic association study was performed in 194 CI patients and 365 non-CI subjects by specifically characterizing 6 SNPs in the human TP gene (rs2271875, rs768963, rs2238634, rs11085026, rs4523 and rs4806942). Analysis demonstrated that there were significant differences in the overall distribution of genotypes and dominant or recessive models of rs2271875 and rs768963 between the CI and the non-CI groups. Multiple logistic regression analysis revealed that the C allele of rs768963 was significantly associated with CI (p = 0.029), even after adjusting for confounding factors (odds ratio: 2.41). Further, the C-T-C haplotype of rs768963-rs2238634-rs4806942 was significantly more frequent in the CI group (23.0%) than in the non-CI group (17.7%). These results suggest that specific SNPs and haplotypes may have utility as genetic markers for the risk of CI and that TP or a neighboring gene is associated with the increased susceptibility to CI. 相似文献
30.
An ulnar recurrent adipofascial flap was raised and turned over to reconstruct massive defects around the elbow and forearm after wide resection of malignant tumours. Compared to the fasciocutaneous flap, the ulnar recurrent adipofascial flap has the following advantages: (1) a larger flap can be harvested without the problem of primary closure of the donor site, (2) the contour and scar of the donor site is reasonably acceptable since no tension is presented, (3) the flap can be turned over to cover a wider area, and (4) debulking of the flap can be performed during the operation if needed. The rotation arc of the ulnar recurrent adipofascial flap reaches a wide region, including the distal one-half of the upper arm, the elbow, and the proximal two-thirds of the forearm. Sensory deficit in the forearm was avoided in our patients because meticulous separation and preservation of the medial cutaneous nerve of the forearm was achieved without jeopardising the blood supply to the flap. The ulnar recurrent adipofascial flap is an easy and reliable option for one-stage reconstruction of massive defects around the elbow. 相似文献