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91.
Masakazu Yamamoto Masahiro Yoshida Junji Furuse Keiji Sano Masayuki Ohtsuka Shingo Yamashita Toru Beppu Yukio Iwashita Keita Wada Takako Eguchi Nakajima Katsunori Sakamoto Koichi Hayano Yasuhisa Mori Koji Asai Ryusei Matsuyama Teijiro Hirashita Taizo Hibi Nozomu Sakai Tsutomu Tabata Hisato Kawakami Hiroyuki Takeda Takuro Mizukami Masato Ozaka Makoto Ueno Yoichi Naito Naohiro Okano Takayuki Ueno Susumu Hijioka Satoru Shikata Tomohiko Ukai Steven Strasberg Michael G. Sarr Palepu Jagannath Tsann‐Long Hwang Ho‐Seong Han Yoo‐Seok Yoon Hee Jung Wang Shao‐Ciao Luo Ren Adam Mariano Gimenez Olivier Scatton Do‐Youn Oh Tadahiro Takada 《Journal of hepato-biliary-pancreatic sciences》2021,28(1):1-25
92.
Yasuyuki Fujita Takako Ohmaru Nakanishi Maiko Sugitani Kiyoko Kato 《Ultrasound in medicine & biology》2019,45(1):93-97
Point shear wave elastography is an ultrasonography technique used to evaluate tissue elasticity. We examined whether placental elasticity is useful for predicting the onset of pre-eclampsia. Two hundred twenty-one participants were divided into two groups: one group at low risk (n?=?185) and the other at high risk (n?=?36) for pre-eclampsia. The two groups were compared with respect to shear wave velocity (SWV) of the placenta. Use of SWV as a predictor of pre-eclampsia was also investigated by creating a receiver operating characteristic (ROC) curve. The ROC curve was used to set a cutoff SWV value for predicting pre-eclampsia. The SWV of the high-risk group was significantly higher than that of the low-risk group (p < 0.001). Thirteen participants developed pre-eclampsia after SWV measurements, and the SWVs of these participants were significantly higher than those of participants in who pre-eclampsia did not develop. The cutoff value and area under the ROC curve were 1.188 m/s and 0.9118, respectively. Placental elasticity was significantly increased even before the onset of pre-eclampsia onset and, thus, may be a parameter used to predict the onset of pre-eclampsia. 相似文献
93.
Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages 总被引:6,自引:0,他引:6
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94.
Takako Taguchi Hiroshi Kijima M.D. Toshio Mitomi R. Yoshiyuki Osamura 《Journal of gastroenterology》1991,26(3):294-302
The immunohistochemical localization of five antibodies against carcinoembryonic antigen (CEA), CA19-9, keratin, α-tubulin
and secretory component (SC) was investigated in 14 lesions of adenocarcinoma (AC), 22 of adenoma with high-grade atypia (AH),
50 of adenoma with low-grade atypia (AL), and 15 of non-neoplastic mucosa (NNM) of the large intestine. The positive patterns
for each staining were divided into three categories (patterns 1,2, and 3). All neoplastic lesions (AC, AH and AL) were positive
for CEA, while 85.7% of AC, 36.4% of AH and 6.0% of AL showed strongly positive staining (pattern 3). 78.6% of AC and 54.5%
of AH were positive for CA19-9 in comparison to 20.0% of AL. For keratin, more than 95% ofthe neoplastic lesions were positive,
while 78.6% of AC, 27.3% of AHand 22.0% of AL showed strongly positive staining (pattern 3). For a-tubulin, more than 85%
of neoplstic lesions were positive, while 50.0% of AC, 36.3% of AH and 26.0% of AL showed strongly positive staining (pattern
3). For SC, in contrast, 42.9% of AC, 27.3% of AH and 8.0% of AL were negative, but 93.3% of NNM were positive. It was concluded
that the positive staining rate, especially the rate of pattern 3 for each antibody correlated with the degree of atypia of
the colorectal neoplastic lesions (AC, AH and AL). 相似文献
95.
96.
97.
Kiminori Terui Tsutomu Toki Takashi Taga Shotaro Iwamoto Takako Miyamura Daisuke Hasegawa Hiroshi Moritake Asahito Hama Kentaro Nakashima Rika Kanezaki Ko Kudo Akiko M. Saito Keizo Horibe Souichi Adachi Daisuke Tomizawa Etsuro Ito 《Genes, chromosomes & cancer》2020,59(3):160-167
Myeloid leukemia associated with Down syndrome (ML‐DS) is characterized by a predominance of acute megakaryoblastic leukemia, the presence of GATA1 mutations and a favorable outcome. Because DS children can also develop conventional acute myeloid leukemia with unfavorable outcome, detection of GATA1 mutations is important for diagnosis of ML‐DS. However, myelofibrosis and the significant frequency of dry taps have hampered practical screening of GATA1 mutations using bone marrow (BM) samples. In response to those problems, 82 patients were enrolled in the Japanese Pediatric Leukemia/Lymphoma Study Group AML‐D11 study. GATA1 mutations were analyzed by Sanger sequencing (SS) using genomic DNA (gDNA) from BM and cDNA from peripheral blood (PB) followed by targeted next‐generation sequencing (NGS) using pooled diagnostic samples. BM and PB samples were obtained from 71 (87%) and 82 (100%) patients, respectively. GATA1 mutations were detected in 46 (56%) and 58 (71%) patients by SS using BM gDNA and PB cDNA, respectively. Collectively, GATA1 mutations were identified in 73/82 (89%) patients by SS. Targeted NGS detected GATA1 mutations in 74/82 (90%) patients. Finally, combining the results of SS with those of targeted NGS, GATA1 mutations were identified in 80/82 (98%) patients. These results indicate that SS using BM gDNA and PB cDNA is a rapid and useful method for screening for GATA1 mutations in ML‐DS patients. Thus, a combination of SS and targeted NGS is a sensitive and useful method to evaluate the actual incidence and clinical significance of GATA1 mutations in ML‐DS patients. 相似文献
98.
99.
Takako Taniguchi Ayumi Sekiya Mariko Higa Yuji Saeki Kazumi Umeki Akihiko Okayama Tetsuya Hayashi Naoaki Misawa 《Journal of clinical microbiology》2014,52(1):95-102
Helicobacter cinaedi infection is recognized as an increasingly important emerging disease in humans. Although H. cinaedi-like strains have been isolated from a variety of animals, it is difficult to identify particular isolates due to their unusual phenotypic profiles and the limited number of biochemical tests for detecting helicobacters. Moreover, analyses of the 16S rRNA gene sequences are also limited due to the high levels of similarity among closely related helicobacters. This study was conducted to evaluate intact-cell mass spectrometry (ICMS) profiling using matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) as a tool for the identification of H. cinaedi. A total of 68 strains of H. cinaedi isolated from humans, dogs, a cat, and hamsters were examined in addition to other Helicobacter species. The major ICMS profiles of H. cinaedi were identical and differed from those of Helicobacter bilis, which show >98% sequence similarity at the 16S rRNA sequence level. A phyloproteomic analysis of the H. cinaedi strains examined in this work revealed that human isolates formed a single cluster that was distinct from that of the animal isolates, with the exception of two strains from dogs. These phyloproteomic results agreed with those of the phylogenetic analysis based on the nucleotide sequences of the hsp60 gene. Because they formed a distinct cluster in both analyses, our data suggest that animal strains may not be a major source of infection in humans. In conclusion, the ICMS profiles obtained using a MALDI-TOF MS approach may be useful for the identification and subtyping of H. cinaedi. 相似文献
100.
Yozo Miyaoka Ichiro Ashida Hajime Iwamori Shin-ya Kawakami Yuko Tamaki Takako Yamazaki 《Journal of medical engineering & technology》2014,38(5):281-285
Masseter activity patterns during chewing, which were quantitatively assessed using T50 values, were compared between the right and left sides of healthy young males. Surface electromyograms were recorded from both masseters, and each participant was asked to chew four different agar samples at his own pace across two separate sessions. The four agar samples, each possessing differing textural properties, consisted of two normal and two distinctive agar varieties. The Pearson’s correlation coefficient was calculated for each pair of T50 values to evaluate the degree of synchronization of activity patterns between both masseters. A three-way analysis of variance revealed significant main effects of the ‘participant’ and ‘experimental session’ factors, but not of the ‘test food’. The number of significant coefficients increased stepwise by increasing the number of chews per sequence. These results suggest the importance of the initial stages of chewing sequences in facilitating the synchronization of bilateral masseter activity patterns. 相似文献