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51.
52.
Lectin binding was cytofluorometrically measured on fractionated keratinocytes of guinea pig. Free keratinocytes were obtained by treatment of EDTA and trypsin. After the treatment, they were separated into 3 fractions by centrifugation on a continuous colloidal silica (Percoll) density gradient. Cells in each fraction were stained by biotinyl lectins and avidin-FITC, and fluorescence intensity was measured by cytofluorometry. Results obtained indicate that little cell surface glycoconjugate is lost during the preparation of free keratinocytes. 相似文献
53.
54.
Kuwanons N and O, two new flavonoid derivatives with a fused dihydrochalcone partial moiety, and four known flavonoid derivatives, morusin, kuwanons G, H, and K, were isolated from the ethyl acetate extract of the root bark of MORUS LHOU (SER.) Koidz. The structures of kuwanons N and O were shown to be 1 and 2, respectively, on the basis of spectral data. They are regarded biogenetically as Diels-Alder adducts of a chalcone and a dehydroprenyl flavonoid. 相似文献
55.
Yoshiyuki Suehara Shinji Kohsaka Takuo Hayashi Keisuke Akaike Aiko Kurisaki-Arakawa Shingo Sato Eisuke Kobayashi Sho Mizuno Toshihide Ueno Takeshi Morii Tomotake Okuma Taisei Kurihara Nobuhiko Hasegawa Kei Sano Keita Sasa Taketo Okubo Youngji Kim Hiroyuki Mano Tsuyoshi Saito 《Clinical orthopaedics and related research》2021,479(4):838
56.
57.
Four new isoprenylated xanthones, cudraxanthone H,I,J, and K were isolated from the ethanol extract of the root bark of CUDRANIA TRICUSPIDATA (Carr.) Bur. (Moraceae), collected in China. The structures of cudraxanthones H,I,J, and K were shown to be 1- 4, respectively, on the basis of chemical and spectral evidence. 相似文献
58.
Three new isoprenylated xanthones, cudraxanthones E, F, and G along with a known xanthone, 6-deoxyisojacareubin, were isolated from the ethanol extract of the root bark of CUDRANIA TRICUSPIDATA (Moraceae), collected in China. The structures of cudraxanthones E, F, and G were shown to be 1-3, respectively, on the basis of spectral evidence. 相似文献
59.
Yoshida M Abe O Uchino J Kikuchi K Abe R Enomoto K Tominaga T Fukami A Sakai K Koyama H Sugimachi K Nomura Y Hattori T Ogawa N 《Breast cancer (Tokyo, Japan)》1997,4(2):103-113
A multi-center, randomized controlled collaborative study was conducted in 310 institutions located throughout Japan for 3 years and 9 months from February 1985 until October 1988 to evaluate the efficacy of post-operative adjuvant therapy for patients who had previously undergone curative surgery for treatment of Stage IIIa breast cancer. Patients with estrogen receptor-positive [ER( + )] breast cancer were treated with two types of regimens, ie, cyclophosphamide + adriamycin + fluorouracil (CAF; 2 cycles) + Futraful (FT) or CAF (2 cycles) + FT + tamoxifen (TAM), and the clinical benefit of additional use of TAM was evaluated. Of the 509 ER( + ) patients registered for the trial, 473 patients (92.9%) were eligible for evaluation. The 5-year survival rate was 77.2% for the CAF + FT group and 74.6% for the CAF + FT+TAM group, and the 5-year disease-free survival rate was 56.7% for the CAF+FT group and 59.2% for the CAF + FT + TAM group. Neither the survival rate nor the disease-free survival rate differed significantly between the groups. Analyses by factor revealed that the 5-year disease-free rate for lymph node-negative patients in the CAF + FT + TAM group was significantly higher than that for the corresponding patients in the CAF + FT group. No differences were noted in the incidence of adverse reactions between the two treatment groups, other than an increase in LDH (the frequency of which was higher in the CAF + FT+TAM group than in the CAF + FT group). Patients with estrogen receptor-negative [ER( -)] breast cancer were treated with two types of regimens, ie, CAF + FT or CAF + FT + adriamycin (ADR), and the clinical benefit of the combined use of intermittent doses of ADR was evaluated. Of the 514 ER(-) patients registered in the trial, 478 (93.0%) were eligible for evaluation. The 5-year survival rate was 64.9% for the CAF + FT group and 63.0% for the CAF + FT + ADR group, and the 5-year disease-free survival rate was 59.2% for both CAF + FT and CAF + FT + ADR groups. Neither the survival rate nor the disease-free survival rate differed significantly between the groups. There were no significant differences between these groups in analyses by nodal or menopausal status. The incidences of adverse reactions including anorexia, nausea/vomiting and alopecia were higher in the CAF + FT+ADR group than in the CAF + FT group. 相似文献
60.
Omoto M Imai T Seki K Nomura R Otahara Y 《Environmental health and preventive medicine》1997,2(3):105-116
Based on the fact that chemical products such as binding agents are produced by mixing three kinds of phosphates with different
ratios, we mixed metaphosphate, polyphosphate and pyrophosphate. Each was made to Na-phosphate, K-phosphate, and Ca-phosphate
and each was mixed with commercial feeds so that the content of P would be approximately 0.1, 0.15, 0.3, 0.4, 0.6 and 1.0%.
The prepared pellets were given to ICR, CF # 1 and AKR strains of mice at 29 days of age for 680 days and observations were
made through this experimental period at different stages. The observations were also carried out on the mice administered
with the experimental feeds for 1.5 months from 9 to 10.5 months of age. The observations were compared with those of the
control group at all times. As a result, plasma 1 α, 25 (OH)2 D3 and P levels were always significantly higher in the phosphate administered groups relative to the control. Urine P and Fe
increased while urine Ca decreased in the phosphate-treated groups.
The effect of phosphates on the bones was studied taking soft X-ray pictures of hind legs and applying microdensitometry to
them. Through these observations we recognized thinning of the cortex of bones, reduction of marrow trabecules and development
of osteophyte. Histological observations disclosed that changes in knee joint tissues were apparent; that is, a decrease in
or an irregular loss of the number of cells in superficial, intermediate, and radial strata of the joint cartilage, proliferation
of subchondral bone, and the development of osteophytes were noted. As for muscles, diameters of musclar fibers became smaller;
in particular, type II fibers showed greater shrinkage. Regarding kidneys, swelling and atrophy of glomerular capillaries,
proliferation of mesangial cells, nephroselerosis, swelling, thinning, and loss of tubular epithelium, interstitial tissue
inflammation, development of cylindruria, and deposition of calcium were observed. All these changes seem to be a particularly
advanced aspect of the changes which are more pronounced with increasing dose and age.
These changes were found even in the group administered with the feed containing 0.1% phosphorus, and, these changes were
dependent on the concentration level of P. It was observed that administration to older subjects for a short term (1.5 months)
produced effects stronger than those to younger subjects administered for a long term (10.5 months).
The effects of condensed Ca-phosphate on bones were similar to those of condensed Na- and K-phosphates, and, hence, it was
supposed that these effects were caused by phosphate radicals.
An erratum to this article is available at . 相似文献