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51.
目的探讨老年冠心病合并糖尿病患者经皮冠状动脉介入(PCI)置入雷帕霉素洗脱支架(SES)治疗的远期疗效。 方法回顾性随机入选2003年1月至2007年12月住院期间老年冠心病合并糖尿病患者行PCI 100例,并入选同时期100例无糖尿病的冠心病患者行PCI为对照组。随访5年,随访包括心绞痛复发、死亡、心肌梗死、卒中和再次血运重建的主要不良心脑血管事件。结果 两组支架术成功率均为100%。随访率100%,随访5年,糖尿病组与非糖尿病组术后并发症发生率(8.0%、7.0%)、卒中发生率(5%、3.0%)、心源性死亡率(0%、0%)差异无显著性(均为ρ〉0.05)。再次血运重建率(30.0%、14.0%)、非致死性心肌梗塞(6.0%、2.0%)心绞痛复发率(42%、20%)、全因死亡率(10%、2.0%)糖尿病组高于非糖尿病组;但心源性病死率均为0%。结论:老年患者选择性冠脉内置入药物洗脱支架安全,成功率高,远期疗效尚好,但糖尿病仍是远期不良预后的独立预测因素。 相似文献
52.
J. STIRTON BA Adv. Diploma in Counselling App Soc Studs J. POWNALL RGN RSCH Dip Paed Oncology & B. CARROON EN RSCN 《European journal of cancer care》1997,6(2):154-155
The paper describes a holiday for a group of adolescents with cancer (from the Young Oncology Unit at the Christie Hospital, Manchester, UK) at Malcolm Sargent House, Prestwick, Scotland. The aim was to provide an opportunity for young people with cancer to build and to develop therapeutic relationships away from the pressures of hospital, home and treatment. The nature and range of care given by the nurses and social worker who accompanied them is described and includes accounts of individual progress which are demonstrated by brief case studies. 相似文献
53.
FO Alaneme EN Maduagwu 《Malawi medical journal : the journal of Medical Association of Malawi》2004,16(1):6-8
Albino Wistar rats (Rattus norvegius) fed semi-purified diets containing 3.5%, 8%, 27%, and 64% casein, respectively, as the protein source, were poisoned with an intraperitoneal dose of 20mg N-nitrosodimethylamine (NDMA)/kg, following cannulation of the bile duct, in vitro, under urethane anaesthesia. Bile exudates was collected at designated time intervals and analysed for unchanged NDMA using thin layer chromatography and gas liquid chromatography methods. Rats on 64% high protein diet (HPD) were the highest excretors of NDMA, followed by rats on the 3.5% kwashiorkorigenic diet (KWD), 8% low protein diet (LPD) and 27% normal protein diet (NDP) as the least excretors, in that order. The corresponding values for culmulative excretions of NDMA were 4.38%, 2.74%, 2.96% and 4.11%, and for elimination rate contents they were 54.05Kh−1, 23.01Kh−1, 23.76Kh−1 and 48.88Kh−1, while the respective elimination half-life values were 0.013h, 0.031h, 0.029h and 0.014h. The toxicological and pharmacological implication of the pharmacokinetic findings are discussed. 相似文献
54.
Increased trinucleotide repeat instability with advanced maternal age 总被引:15,自引:14,他引:1
Nucleotide repeat instability is associated with an increasing number of
cancers and neurological disorders. The mechanisms that govern repeat
instability in these biological disorders are not well understood. To
examine genetic aspects of repeat instability we have introduced an
expanded CAG trinucleotide repeat into transgenic mice. We have detected
intergenerational CAG repeat instability in transgenic mice only when the
transgene was maternally transmitted. These intergenerational instabilities
increased in frequency and magnitude as the transgenic mother aged.
Furthermore, triplet repeat variations were detected in unfertilized
oocytes and were comparable with those in the offspring. These data show
that maternal repeat instability in the transgenic mice occurs after
meiotic DNA replication and prior to oocyte fertilization. Thus, these
findings demonstrate that advanced maternal age is an important factor for
instability of nucleotide repeats in mammalian DNA.
相似文献
55.
EN Lundqvist† YB Wahlin‡ M Bergdahl‡ J Bergdahl§ 《Journal of the European Academy of Dermatology and Venereology》2006,20(6):661-666
BACKGROUND: Erosive lichen planus is a severe, recurrent and recalcitrant disease that affects several mucosal areas, mostly the genital area and the mouth, but also, for example, the oesophagus and perianal area. The disease causes serious symptoms, because of the raw, de-epithelialized mucosa and healing with scars/adhesions, which affect the patient's life in many ways. It causes, for example, difficulties in eating, drinking and going to the bathroom. Treatment is complicated and, so far, few therapeutic drugs other than steroids have been reported. OBJECTIVES: As the disease has severe implications on the patient's life it is important to investigate the psychological health of the patients, as well as the influence of stress on their health and wellbeing, in order to improve treatment. STUDY DESIGN, SUBJECTS AND METHODS: Forty-nine consecutive patients with erosive lichen planus were included during a 1-year period. The study was carried out as 'state-of-the-last-month', and stress, state anxiety, depression and 'erosive lichen planus factors', i.e. symptoms affecting daily life, were assessed. RESULTS: Eighty-seven per cent of the patients had symptoms, severely affecting daily life. Unexpectedly, oral symptoms seemed to be the most prominent. Our results showed that depression, anxiety and stress were more common in patients with erosive lichen planus than in a control group. DISCUSSION AND CONCLUSIONS: Erosive lichen planus is a severe disease with symptoms and complications affecting the patient's life. Our results indicate that their psychological health is also affected and emphasize the need for close collaboration between physicians, dentists with special knowledge in oral medicine and counsellors/psychologists to optimize handling of these patients. 相似文献
56.
Congenital chylothorax in siblings 总被引:1,自引:0,他引:1
GF Fox D Challis KK O'Brien EN Kelly G Ryan 《Acta paediatrica (Oslo, Norway : 1992)》1998,87(9):1010-1012
We describe two cases of congenital chylothorax in siblings with important differences from previously described familial cases. Our findings support the likelihood of an autosomal recessive inheritance in some cases of this condition, rather than X-linked recessive inheritance, which has also been suggested. Autopsy findings from one of these cases and others previously described suggest that the pathophysiological mechanisms involved may be variable. 相似文献
57.
F. GRUND H. T. SOMMERSCHILD A. WINECOFF M. R. UJHELYI T. T
NNESSEN K. A. KIRKEB
EN D. L. RUTLEN A. ILEBEKK 《Acta physiologica (Oxford, England)》1997,161(3):303-309
The importance of nitric oxide in regulating basal arterial blood flow has been examined in several different vascular beds by intra-arterial infusion of inhibitors of nitric oxide synthesis, but not in the arterial vascular bed of the liver. In the present study, NG-nitro-L -arginine (L -NNA), in a dose of 0.5 and 1.0 μmol mL?1 of hepatic arterial blood flow, was infused for 5 min into the hepatic artery in seven pigs anaesthetized with pentobarbital sodium. The haemodynamic effects observed by the first infusion were not further enhanced by the second infusion. Hepatic arterial resistance increased by 143 ± 38% and hepatic arterial blood flow declined by 38 ± 10%. A systemic effect due to `spillover' was observed, as evidenced by an increase in mean aortic blood pressure of 24 ± 4 mmHg. However, no significant increase in arterial mesenteric resistance was observed and total liver blood flow remained unchanged. Hepatic arterial vasodilation in response to occlusion of the portal vein, the arterial buffer response, remained intact after inhibition of nitric oxide synthesis. Liver lobe thickness, measured by an ultrasonic technique,was not found to change with inhibition of arterial nitric oxide synthesis, excluding a significant direct effect of arterial nitric oxide on liver capacitance. In conclusion, nitric oxide is an important regulator of hepatic arterial resistance, but does not mediate the hepatic arterial buffer response and was not found to play any significant role in total hepatic capacitance regulation. 相似文献
58.
Fikriye Yasemin
ZATK Orhan
ZATK Yasemin TEKEN Semra YTASLAN Neziha Senem ARI 《Turkish Journal of Medical Sciences》2021,51(3):1530
Backround/aimCyclophosphamide (CP) is a drug used for treatment of many malignant diseases. However, it can cause serious side effects such as hemorrhagic cystitis and male infertility. Hydrogen sulfide (H2S) is a gaseous mediator and is suggested to have antioxidant, antiinflammatory, and antiapoptotic effects. In this study, dose-dependent effects of H2S donor sodium hydrosulfide (NaHS) on cyclophosphamide-induced hemorrhagic cystitis and testicular dysfunction were investigated in rats.Material and methodsRats were divided into 5 groups (n = 8): control, CP, NaHS25 μmol/kg, NaHS50 μmol/kg, and NaHS100 μmol/ kg. After treatment for 7 days intraperitoneally (ip), a single ip dose of CP 200 mg/kg was given on the 8th day. Then, treatment was continued for 7 days. In bladder and testicular tissues, IL 6, IL 10, cGMP, NO, H2S, FSH, LH, and testosterone levels were measured by ELISA. Histopathological examination with H&E staining, as well as immunohistochemical staining for acrolein in bladder and caspase-3 and APAF-1 in testis were performed.ResultsNaHS prevented the increased IL 6 and IL 10 values induced by CP as well as prevented the decrease in cGMP values associated with CP. There was no significant change in FSH values, but the LH value, which increased with CP, decreased with 25, 50, and 100 μmol/kg NaHS. In contrast, testosterone decreased in the CP group and increased in the treatment groups. NaHS was effective in many biochemical and histopathological parameters at 25 and 50 μmol/kg doses, and this effect decreased at 100 μmol/kg dose.ConclusionH2S has a protective and therapeutic effect on hemorrhagic cystitis and testicular dysfunction induced by cyclophosphamide. It can be suggested that H2S is a promising molecule in facilitating cancer treatment. 相似文献
59.
Spectrum of APC and MUTYH germ‐line mutations in Russian patients with colorectal malignancies 下载免费PDF全文
G.A. Yanus T.A. Akhapkina A.O. Ivantsov E.V. Preobrazhenskaya S.N. Aleksakhina I.V. Bizin A.P. Sokolenko N.V. Mitiushkina E.Sh. Kuligina E.N. Suspitsin A.R. Venina M.M. Holmatov O.A. Zaitseva O.S. Yatsuk D.V. Pashkov A.M. Belyaev A.V. Togo E.N. Imyanitov A.G. Iyevleva 《Clinical genetics》2018,93(5):1015-1021
Distribution of cancer‐predisposing mutations demonstrates significant interethnic variations. This study aimed to evaluate patterns of APC and MUTYH germ‐line mutations in Russian patients with colorectal malignancies. APC gene defects were identified in 26/38 (68%) subjects with colon polyposis; 8/26 (31%) APC mutations were associated with 2 known mutational hotspots (p.E1309Dfs*4 [n = 5] and p.Q1062fs* [n = 3]), while 6/26 (23%) mutations were novel (p.K73Nfs*6, p.S254Hfs*12, p.S1072Kfs*9, p.E1547Kfs*11, p.L1564X and p.C1263Wfs*22). Biallelic mutations in MUTYH gene were detected in 3/12 (25%) remaining subjects with polyposis and in 6/90 (6.7%) patients with colorectal cancer (CRC) carrying KRAS p.G12C substitution, but not in 231 early‐onset CRC cases negative for KRAS p.G12C allele. In addition to known European founder alleles p.Y179C and p.G396D, this study revealed a recurrent character of MUTYH p.R245H germ‐line mutation. Besides that, 3 novel pathogenic MUTYH alleles (p.L111P, p.R245S and p.Q293X) were found. Targeted next‐generation sequencing of 7 APC/MUTYH mutation‐negative DNA samples identified novel potentially pathogenic POLD1 variant (p.L460R) in 1 patient and known low‐penetrant cancer‐associated allele CHEK2 p.I157T in 3 patients. The analysis of 1120 healthy subjects revealed 15 heterozygous carriers of recurrent MUTYH mutations, thus the expected incidence of MUTYH‐associated polyposis in Russia is likely to be 1:23 000. 相似文献
60.