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41.
42.
GT Clark S Sakai R Merrill VF Flack C McCreary 《Cephalalgia : an international journal of headache》1995,15(6):511-518
Thirty-six tension-type headache subjects and 36 non-headache matched controls recorded their temporalis muscle electromyographic (EMG) activity and their pain intensity, stress and physical activity levels in a daily diary. Measurements were performed every 30 min for 6 days (EMG 3 days only). A time-lagged cross-correlational analysis between pain, stress, physical activity, and EMG shows that the highest correlation coefficient values occurred between pain and stress at the same ( r =0.33) and at the two preceding 0.5 h time points ( r =0.21 and r =0.26) in the headache group. Virtually no correlation was found between pain, stress, or physical activity with EMG for either group. These data show that temporalis muscle activity levels were not related to the rise and fall of the subjects' pain or stress levels. Conversely, elevated stress appeared to be highly related to pain; it occurs as both an antecedent and simultaneous event with elevated headache pain. 相似文献
43.
The distinction between communicating and non-communicating intracranial arachnoidal cysts is important in medical management. Mainly the latter type will benefit from surgery which aims at establishing a communication between the cyst and the subarachnoidal space or ventricular system. We report the case history of two patients in whom congenital cerebral arachnoidal cysts are diagnosed at adult age and illustrate the role of scintigraphy with 111-In-Ca-DTPA to prove the communication of the cysts with the subarachnoidal space. This technique is safe and simple and gives less irradiation and discomfort to the patient than other methods. 相似文献
44.
Antonio Nicolucci MD Bernard Charbonnel MD Marília B. Gomes MD Kamlesh Khunti MD Mikhail Kosiborod MD Marina V. Shestakova MD Iichiro Shimomura MD Hirotaka Watada MD Hungta Chen PhD Javier Cid-Ruzafa MD Peter Fenici MD Niklas Hammar PhD Filip Surmont PhD Fengming Tang MS Stuart Pocock PhD 《Diabetes, obesity & metabolism》2019,21(11):2474-2485
45.
Corinne Faivre-Finn Michael Snee Linda Ashcroft Wiebke Appel Fabrice Barlesi Adityanarayan Bhatnagar Andrea Bezjak Felipe Cardenal Pierre Fournel Susan Harden Cecile Le Pechoux Rhona McMenemin Nazia Mohammed Mary OBrien Jason Pantarotto Veerle Surmont Jan P Van Meerbeeck Penella J Woll Fiona Blackhall 《The lancet oncology》2017,18(8):1116-1125
46.
Mosaicism in sporadic neurofibromatosis 2 patients 总被引:4,自引:1,他引:4
More than half of neurofibromatosis 2 (NF2) patients represent de novo
mutations which could have occurred at either pre-zygotic or post- zygotic
stages. A post-zygotic mutation can result in mosaicism. In four sporadic
NF2 patients, we found NF2 mutations in only a portion of corresponding
leukocytes. In two other sporadic patients, no mutations were found in
leukocytes but constitutional NF2 mutations were suggested by identical
mutations in different tumors from each patient. We screened leukocyte DNA
from a total of 16 inherited and 91 sporadic NF2 patients, and found NF2
mutations in 13 (81%) of the former and in 46 (51%) of the latter cases.
The 30% difference in the rate of detection of mutations ( P = 0.051) might
be partially explained by mosaicism in a portion of sporadic NF2 patients
who carry the mutations in such a fashion that their leukocytes are
unaffected. Among sporadic cases, we found mutations more frequently in
patients with severe phenotypes (59%) than in patients with mild phenotypes
(23%) (difference of 36%, P = 0.007). Mosaicism might be more common in the
latter patient group since small populations of mutation-bearing cells can
in some cases result in mild phenotypes and can also lead to difficulties
in identifying mutations. No mutations were found in eight patients
suspected of having NF2. Mosaicism with an extremely small population of
affected cells may explain the incomplete phenotypes in some of these
patients and the lack of mutations in their leukocytes. These findings
suggest that mosaicism is relatively common in NF2 and may have important
implications for diagnosis, prognosis and genetic counseling.
相似文献
47.
Mencacci A; Cenci E; Del Sero G; Fe d'Ostiani C; Mosci P; Montagnoli C; Bacci A; Bistoni F; Quesniaux VF; Ryffel B; Romani L 《International immunology》1998,10(1):37-48
To define the immunological functions of tumor necrosis factor (TNF) in
Candida albicans infection, TNF/lymphotoxin (LT)-alpha double-deficient
mice were assessed for susceptibility to systemic or gastrointestinal
infection and parameters of innate and adaptive Th immunity. When compared
to wild-type mice, TNF/LT-alpha-deficient mice were more susceptible to
either type of infection caused by virulent or low- virulence C. albicans
cells. Susceptibility to infection correlated with impaired development of
protective Th1 responses, in spite of the production of bioactive IL-12.
The occurrence of predominant Th2 responses was associated with both
impaired antifungal effector functions of neutrophils and a defective
expression of co-stimulatory molecules on macrophages. All functions were
improved upon administration of recombinant TNF-alpha, also resulting in
increased resistance to infection. These findings indicate that the
protective effect of TNF-alpha in candidiasis relies on the induction of
antifungal Th1 responses, possibly occurring through stimulation of
antifungal effector functions and co-stimulatory activities of phagocytic
cells.
相似文献
48.
49.
50.
R. Vanhoof K. Camps M. Carpentier S. De Craeye J. Frans Y. Glupczynski P. Goffinet B. Gordts D. Govaerts L. Ide P. Lefèvre M. Lontie R. Cartuyvels F. Meunier B. Mulongo I. Philippart I. Surmont E. Van Bossuyt J. Van Eldere J. Verhaegen 《Pathologie-biologie》2010