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Julia Hobson Phani Gummadidala Brian Silverstrim Dore Grier Janice Bunn Ted James Mercedes Rincon 《Breast cancer research and treatment》2013,139(2):391-401
Development of metastasis in peripheral tissues is a major problem in the fight to cure breast cancer. Although it is becoming evident that chronic inflammation can contribute to tumor progression and metastasis, the effect of acute inflammation in primary tumor is less known. Using mouse models for breast cancer here we show that biopsy of mammary tumors increases the frequency of lung metastases. This effect is associated with the recruitment of inflammatory cells to the lung and elevated levels of certain cytokines such as IL-6 in the lung airways. Antiinflammatory treatment prior to and after the biopsy reduces the development of metastases triggered by the biopsy. In addition, while lack of IL-6 does not affect primary tumor development, it protects from increasing number of metastases upon biopsy. Thus, our studies show that in addition to chronic inflammation, acute immune response caused by invasive procedures in the primary tumor may cause an increased risk on peripheral metastases, but the risk could be decreased by anti-inflammatory treatments. 相似文献
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Michael H. McGillion Emmanuelle Duceppe Katherine Allan Maura Marcucci Stephen Yang Ana P. Johnson Sara Ross-Howe Elizabeth Peter Ted Scott Carley Ouellette Shaunattonie Henry Yannick Le Manach Guillaume Paré Bernice Downey Sandra L. Carroll Joseph Mills Andrew Turner Wendy Clyne P.J. Devereaux 《The Canadian journal of cardiology》2018,34(7):850-862
Worldwide, more than 230 million adults have major noncardiac surgery each year. Although surgery can improve quality and duration of life, it can also precipitate major complications. Moreover, a substantial proportion of deaths occur after discharge. Current systems for monitoring patients postoperatively, on surgical wards and after transition to home, are inadequate. On the surgical ward, vital signs evaluation usually occurs only every 4-8 hours. Reduced in-hospital ward monitoring, followed by no vital signs monitoring at home, leads to thousands of cases of undetected/delayed detection of hemodynamic compromise. In this article we review work to date on postoperative remote automated monitoring on surgical wards and strategy for advancing this field. Key considerations for overcoming current barriers to implementing remote automated monitoring in Canada are also presented. 相似文献
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Countless therapeutic strategies have been explored over many decades to prevent or slow the progression of glioblastoma. Despite radical changes in radiation management in other malignancies, there have been no major advances in the radiotherapeutic approach to glioblastoma in over 30 years. Past hopes to overcome inherent radioresistance with escalating doses have been met with frustration. However, prior clinical trials were performed before temozolomide, a radiosensitizer, altered the standard of care and this has renewed interest in dose escalation. Immunotherapy has led to further excitement, given the substantial responses that have been observed in other cancers when combined with high-dose radiation. In addition, advances in molecular profiling and neuroimaging have created new opportunities to improve patient selection for the most appropriate course of treatment. In this review, we outline past attempts to utilize radiosurgery in glioblastoma and focus on the potential to reintroduce this modality of dose escalation in the setting of modern and emerging systemic agents, molecular studies and imaging analyses. 相似文献
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Rebecca Erwin Wells MD MPH Catherine E. Kerr PhD Jennifer Wolkin PhD Michelle Dossett MD PhD Roger B. Davis ScD Jacquelyn Walsh BS Robert B. Wall MDiv MSN Jian Kong MD MPH Ted Kaptchuk Daniel Press MD Russell S. Phillips MD Gloria Yeh MD MPH 《Journal of the American Geriatrics Society》2013,61(4):642-645
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