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991.
I M Marquez L C Fish J P Stella 《American journal of orthodontics and dentofacial orthopedics》2000,117(2):130-139
Distraction osteogenesis has been used to lengthen the mandible in patients with hemifacial microsomia. Questions regarding soft tissue and skeletal growth after distraction osteogenesis have not been clearly elucidated in the literature. In this case report, a 2-year follow-up of distraction osteogenesis in a 7 year old boy is documented with lateral and posterior/anterior cephalometric analysis. The analysis was performed preoperatively and at specific postsurgical periods to evaluate the facial soft tissue and skeletal growth patterns. Objective analysis of this growing patient after distraction osteogenesis clearly demonstrates that the anteroposterior elongation of the mandible is relatively stable, whereas the vertical lengthening and soft tissue effects are minimal. Critical evaluation of other patients who have undergone distraction osteogenesis is needed to determine if this was an isolated incident or the expected result in similar patients. 相似文献
992.
Stella C. Knight Sharifah Iqball Mary S. Roberts Steven Macatonia Penelope A. Bedford 《European journal of immunology》1998,28(5):1636-1644
Primary proliferative T cell responses require stimulation with antigen-pulsed dendritic cells (Ag-DC). Here we show that for optimal stimulation, dendritic cells (DC) not exposed directly to antigen are also required. Ag-DC added to DC-depleted T cells caused negligible primary stimulation; adding back DC resulted in stimulation. These effects were seen using the contact sensitizer fluorescein isothiocyanate (FITC), FITC conjugated to ovalbumin (FITC-OVA) or influenza virus as antigens. DC co-cultured with Ag-DC (using FITC or FITC-OVA) acquired antigen indicating that antigen was transferred between DC. DC that acquired antigen secondarily were separated by cell sorting and stimulated primary T cell proliferation directly. DC were also pulsed with FITC, washed thoroughly and incubated overnight. Super natants contained shed antigen since DC incubated in these supernatants acquired antigen as indicated by flow cytometry. DC acquiring the shed antigen also stimulated T cell proliferation although the stimulation was not as effective as that seen when cell contact between DC and antigen-bearing DC occurred. Thus, in primary stimulation, activation of T cells may occur when there is an antigen gradient between Ag-DC and DC and the mechanisms underlying these effects are now being sought. We propose that this unique interaction between antigen-presenting cells may be a paradigm for self/non-self discrimination. 相似文献
993.
994.
Zhuoyan Li Myriam Labopin Fabio Ciceri Didier Blaise Johanna Tischer Gerhard Ehninger MT Van Lint Yener Koc Stella Santarone Edouard Forcade Luca Castagna Emmanuelle Polge Audrey Mailhol Annalisa Ruggeri Mohamad Mohty Bipin N. Savani Arnon Nagler 《American journal of hematology》2018,93(6):769-777
Secondary acute myeloid leukemia (sAML) traditionally has inferior outcomes compared to de novo AML. Allogeneic hematopoietic cell transplantation (HCT) is the sole potentially curative therapy. This study analyzes the outcomes for unmanipulated haploidentical HCT (haploHCT) for sAML using the Acute Leukemia Working Party (ALWP) registry of the European Society for Blood and Marrow Transplantation (EBMT). We identified 154 patients with sAML who underwent haploHCT from 2006 to 2016. Median age at HCT was 60 years with time from diagnosis to HCT 5 months. At transplantation, 69 patients were in first CR and 85 had active disease. Fifty‐seven (38.0%) patients underwent myeloablative conditioning and 97 (62.0%) reduced intensity conditioning (RIC) conditioning. Multivariate analysis showed that there was no difference in RI, nonrelapse mortality (NRM), leukemia free survival (LFS), overall survival (OS), or GVHD‐free/relapse free survival (GRFS) for conditioning intensity, age, performance status, or graft source. Active disease was associated with higher RI and inferior LFS, OS, and GRFS compared with patients in CR at time of transplant. T‐cell depletion with anti‐thymoglobulin resulted in higher NRM and inferior LFS, OS, and GRFS compared to post‐transplant cyclophosphamide (PTCy) (HR 2.25, 2.01, 2.16, and 1.73, respectively with P values <.05). Our data shows that haploHCT is a feasible alternative for sAML when matched transplantation is unavailable. 相似文献
995.
Rahul Malhotra Choy-Lye Chei Edward Balan Menon Wai-Leng Chow Stella Quah Angelique Chan 《Topics in stroke rehabilitation》2018,25(4):261-268
Objective To delineate positive aspects of caregiving trajectories among family caregivers of stroke-survivors and determine the impact of stroke-survivor disability, a time-varying factor, on the delineated trajectories.Methods In a longitudinal study, family caregivers of 173 stroke-survivors in Singapore were administered the Positive Aspects of Caregiving scale (PAC scale) thrice (baseline/3 months/6 months). Group-based trajectory modeling delineated positive aspects of caregiving trajectories and identified the impact of stroke-survivor disability on the trajectories.Results Two distinct positive aspects of caregiving trajectories, Persistently Low and Persistently High were delineated. Increase in stroke-survivor disability was associated with a significant downward shift (reduction in positive aspects of caregiving) of the Persistently Low trajectory and a significant upward shift (increase in positive aspects of caregiving) of the Persistently High trajectory. Older caregivers were more likely to follow the Persistently High trajectory.Conclusions Care professionals should be mindful of the heterogeneity in the longitudinal pattern of positive feelings resulting from care provision among family caregivers of stroke-survivors, and the differential impact of stroke-survivor disability on the pattern of positive feelings. Younger caregivers as well as family caregivers who have low positive feelings at the start of their caregiver journey and experience worsening functional disability of their care recipient (stroke-survivor) require greater attention and support. 相似文献
996.
997.
Hypergammaglobulinemia is a strong predictor of disease progression,hepatocellular carcinoma,and death in patients with compensated cirrhosis
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998.
Rationale and design of amphilimus sirolimus‐eluting stents versus zotarolimus‐eluting stents in all‐comers requiring percutaneous coronary intervention (ReCre8): A multicenter randomized clinical trial
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Rik Rozemeijer MD MSc Mèra Stein MD PhD Peter Frambach MD Michiel Voskuil MD PhD Adriaan O. Kraaijeveld MD PhD Ramón Rodríguez‐Olivares MD Leo Timmers MD PhD Bruno Pereira MD Saskia Z. Rittersma MD PhD Pierfrancesco Agostoni MD PhD Pieter A. Doevendans MD PhD FESC Pieter R. Stella MD PhD 《Catheterization and cardiovascular interventions》2018,91(3):410-416
999.
Asymmetric dimethylarginine levels are associated with augmentation index across naïve untreated patients with different hypertension phenotypes
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Eugenia Gkaliagkousi MD PhD Eleni Gavriilaki MD PhD Areti Triantafyllou MD PhD Barbara Nikolaidou MD Panagiota Anyfanti MD Nikolaos Koletsos MD Anastasios Vamvakis MSc Konstantina Dipla PhD Antonios Lazaridis MD Stella Douma MD PhD 《Journal of clinical hypertension (Greenwich, Conn.)》2018,20(4):680-685
Asymmetric dimethylarginine (ADMA) is a robust marker of endothelial dysfunction in patients with essential hypertension. We investigated ADMA levels and their association with vascular damage in untreated hypertension. We enrolled consecutive patients with untreated, recently diagnosed hypertension and age‐matched normotensive individuals. 24‐hour blood pressure, central hemodynamics, and arterial stiffness were recorded. A total of 311 individuals were studied: 165 with essential hypertension, 50 with masked hypertension, 25 with white‐coat hypertension, and 71 normotensive individuals. ADMA levels significantly correlated with aortic augmentation index (AIx75) (r = .156, P = .006), aortic pulse pressure (r = .153, P = .007) and marginally with carotid‐femoral pulse wave velocity (r = .110, P = .051), as well as with diastolic office BP. In the multivariate model, aortic AIx75 and age were the only statistically significant predictors of ADMA. This is the largest study to document an independent association between ADMA and aortic AIx75 but not with other indices of arterial stiffness. 相似文献
1000.
Anomalous coronary artery originating from the opposite sinus of Valsalva (ACAOS), fractional flow reserve‐ and intravascular ultrasound‐guided management in adult patients
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Bart W. Driesen MD Evangeline G. Warmerdam MD Gert‐Jan T. Sieswerda MD PhD Paul H. Schoof MD PhD Folkert J. Meijboom MD PhD Felix Haas MD PhD Pieter R. Stella MD PhD Adriaan O. Kraaijeveld MD PhD Fabiola C. M. Evens MD PhD Pieter A. F. M. Doevendans MD PhD Gregor J. Krings MD PhD Arie P. J. van Dijk MD PhD Michiel Voskuil MD PhD 《Catheterization and cardiovascular interventions》2018,92(1):68-75