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81.
Cancer could be deemed as an abnormal and uncontrolled tissue repair process. Therefore, it would not be surprising that factors that function in the tissue repair process, such as cytokines, chemokines, growth factors and Toll-like receptor (TLR) ligands, as well as growth signals for compensatory proliferation, would also be key factors in regulating and enhancing cancer progression. The TLR pathways, which play a critical role in tissue repair, are also key regulators in cancer progression as well as chemoresistance. TLRs serve as cell surface sensors that can initiate pathways leading to proliferation and chemoresistance; as well as mediators that are able to regulate the infiltrating immune cells to provide further support for cancer progression. 相似文献
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H. T. Sørensen F. H. Steffensen H. C. Schønheyder G. L. Nielsen I. Hansen K. M. Madsen H. Hamburger 《European journal of clinical microbiology & infectious diseases》1998,17(10):690-694
The incidence and case fatality rates of meningococcal disease were assessed in the county of Northern Jutland, Denmark,
during the 16-year period from 1980 to 1995. A total of 320 patients were identified from the Meningococcal Research Database,
which comprises information from the following sources: (i) the Department of Public Health, to whom notification of meningococcal
disease is obligatory; (ii) the Regional Hospital Discharge Registry; and (iii) the register of the regional department of
clinical microbiology. In order to assess prognostic indicators assessable at admission, information was collected for each
patient from hospital records regarding contacts, symptoms and signs on arrival, laboratory data, and course of disease. The
mean incidence was 4.3 cases per 100 000 persons per year (range, 2.7–7.7). The incidence increased slightly during the period
studied. Overall, the case fatality rate was 9.7%, with a significant rise occurring during the period (P=0.016) and a peak occurring in 1992. Advanced age (≥50 years), seizures, impaired consciousness, and skin bleeding on arrival
at hospital were predictors of death. 相似文献
85.
Evaluation of Histo-Blood Group ABO Genotyping in a Danish Population: Frequency of a Novel O Allele Defined as O2 总被引:3,自引:0,他引:3
Niels Grunnet Rudi Steffensen Eric Paul Bennett and Henrik Clausen 《Vox sanguinis》1994,67(2):210-215
Traditional blood group ABO serology is based on immunoreactivity with the carbohydrate determinants A, B and H antigens. Recent advances at the DNA level of the ABO genes have provided a molecular genetic model for the ABO polymorphism. This genetic model has to date only been tested on a limited basis. The present study was initiated to evaluate the universality of the proposed genetic model on a larger group of serologically defined ABO phenotypes. Three hundred healthy Danish blood donors were analysed (A: 50, B: 50, AB: 50, O: 150) by PCR amplification followed by diagnostic restriction enzyme cutting. In all cases A, B, and AB at least one allele of correctly predicted status was found. However, in O phenotype individuals, 11 out of 150 carried one allele discordant to the proposed genetic model. This novel O allele (3.7% allele frequency) was further characterized by diagnostic restriction enzyme analysis in two positions divergent between A and B alleles and by DNA sequencing of the two major exons. The novel O allele is termed O2 as it typed as B in nucleotide position 526 and as A in positions 703, 796, and 803, in contrast to the most predominant O allele termed O1 , which types as A in all 4 positions. The structural defect in the O2 allele appears to be an additional substitution at nucleotide position 802. The results clearly demonstrate that with the addition of the two distinctly different O alleles, O1 , O2 , the previously proposed molecular genetic basis of the ABO polymorphism is quite valid. More importantly the determined characteristics of these two O alleles have practical implications in ABO genotyping, because it establishes within the limits of the number of samples tested that ABO genotypes can be assessed directly by non-allele specific PCR amplification and restriction enzyme analysis. 相似文献
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Birth weight and length as predictors for adult height 总被引:2,自引:0,他引:2
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Thomsen SF Ulrik CS Kyvik KO Larsen K Skadhauge LR Steffensen I Backer V 《Chest》2005,127(6):1928-1934
STUDY OBJECTIVES: Longitudinal data on adult asthma are sparse. The objectives of this study were to determine the incidence of asthma and to establish the risk factors for the development of asthma in subjects who were 12 to 41 years old over an 8-year period. DESIGN: From birth cohorts over the period 1953 to 1982 in The Danish Twin Registry, 19,349 subjects with no history of asthma, as determined by a questionnaire-based survey in 1994, answered a follow-up questionnaire in 2002. The subjects were regarded as incident asthma cases when answering "yes" to the question "Do you have, or have you ever had asthma?" in 2002, and "no" to the same question in 1994. RESULTS: A total of 838 cases (4.3%) of new asthma were identified in 2002. The incidence rates of asthma were 4.5 and 6.4 per 1,000 person-years, respectively, among male and female subjects. For all ages, the probability of adult-onset asthma was greater for female subjects (odds ratio [OR], 1.49; p < 0.001), and for both sexes there was a slow decline in probability with increasing age. There was a positive association between increasing body mass index (BMI) and risk of adult-onset asthma applying to both sexes (OR, 1.05 per unit; p < 0.001). Furthermore, positive associations were found between incident asthma and a history of hay fever (OR: male subjects, 4.2; female subjects, 3.7; p < 0.001), eczema (OR: male subjects, 3.5; female subjects, 2.0; p < 0.001), and both (OR: male subjects, 6.9; female subjects, 8.0; p < 0.001). CONCLUSIONS: There is a continuing high incidence of asthma past childhood that is most pronounced among female subjects. Increasing levels of BMI are associated with a greater likelihood of developing asthma for both sexes. A substantial portion of cases of adult asthma is preceded by upper airway allergic symptoms and/or eczema, thus indicating a shared pathogenesis. 相似文献