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161.
Boris Dzudovic Bojana Subotic Natasa Novicic Jovan Matijasevic Jadranka Trobok Milica Miric Sonja Salinger‐Martinovic Dragana Stanojevic Maja Nikolic Vladimir Miloradovic Natasa Markovic Nikolic Milica Dekleva Danijela Lepojevic Stefanovic Ljiljana Kos Tamara Kovacevic Preradovic Slobodan Obradovic 《The clinical respiratory journal》2020,14(7):645-651
162.
Lakshminarayan V Chinta Liis Lindvere Bojana Stefanovic 《Journal of cerebral blood flow and metabolism》2012,32(9):1718-1724
Vascular transit time is an important indicator of microcirculatory health. We present a second-order-plus-dead-time (SOPDT) model for robust estimation of kinetic parameters characterizing microvascular bolus passage using two-photon fluorescence microscopy (2PFM) in anesthetized rats receiving somatosensory stimulation. This methodology enables quantification of transit time, time-to-peak, overshoot, and rate of bolus passage through the microvascular network. The overall transit time during stimulation, of 2.2±0.1 seconds, was shorter (P∼0.0008) than that at rest (2.7±0.2 seconds). When compared with conventional γ-variate modeling, the SOPDT modeling yielded better quality of fit both at rest (P<0.0001) and on activation (P<0.001). 相似文献
163.
Stefanovic A Stojnic J Jeremic K Jeftovic M Arsenijevic L Zecevic N Atanackovic J 《European journal of gynaecological oncology》2012,33(2):236-239
Malignant fibrous histiocytoma (MFH) is the most common soft-tissue sarcoma of late adult life occurring predominantly in the extremities and the retroperitoneum. MFH of the ovary is very rare, with only six cases previously reported. A 67-year-old woman with a right pelvic tumor highly suspicious of ovarian carcinoma was submitted to exploratory laparotomy. Total abdominal hysterectomy, bilateral salpingo-oophorectomy, total omentectomy, pelvic and paraaortic lymphadenectomy with right hemicolectomy along with permanent cutaneous ileostomy were performed. Since a storiform-pleomorphic type of MHF was diagnosed from histopathological and immunohistochemical findings, chemotherapy was proposed as the postoperative treatment. Despite extensive surgery with negative surgical margins, the patient had recurrence of the tumor within four months, and was submitted to secondary surgery. A combination of chemo- and radiotherapy was performed postoperatively, but the patient developed respiratory problems and died one year later from the primary diagnosis. 相似文献
164.
Guillaume Blin David Nury Sonia Stefanovic Tui Neri Oriane Guillevic Benjamin Brinon Valérie Bellamy Catherine Rücker-Martin Pascal Barbry Alain Bel Patrick Bruneval Chad Cowan Julia Pouly Shoukhrat Mitalipov Elodie Gouadon Patrice Binder Albert Hagège Michel Desnos Jean-Fran?ois Renaud Philippe Menasché Michel Pucéat 《The Journal of clinical investigation》2010,120(4):1125-1139
Cell therapy holds promise for tissue regeneration, including in individuals with advanced heart failure. However, treatment of heart disease with bone marrow cells and skeletal muscle progenitors has had only marginal positive benefits in clinical trials, perhaps because adult stem cells have limited plasticity. The identification, among human pluripotent stem cells, of early cardiovascular cell progenitors required for the development of the first cardiac lineage would shed light on human cardiogenesis and might pave the way for cell therapy for cardiac degenerative diseases. Here, we report the isolation of an early population of cardiovascular progenitors, characterized by expression of OCT4, stage-specific embryonic antigen 1 (SSEA-1), and mesoderm posterior 1 (MESP1), derived from human pluripotent stem cells treated with the cardiogenic morphogen BMP2. This progenitor population was multipotential and able to generate cardiomyocytes as well as smooth muscle and endothelial cells. When transplanted into the infarcted myocardium of immunosuppressed nonhuman primates, an SSEA-1+ progenitor population derived from Rhesus embryonic stem cells differentiated into ventricular myocytes and reconstituted 20% of the scar tissue. Notably, primates transplanted with an unpurified population of cardiac-committed cells, which included SSEA-1– cells, developed teratomas in the scar tissue, whereas those transplanted with purified SSEA-1+ cells did not. We therefore believe that the SSEA-1+ progenitors that we have described here have the potential to be used in cardiac regenerative medicine. 相似文献
165.
Ljubinka Jankovic Velickovic Takanori Hattori Milan Visnjic Irena Dimov Mariola Stojanovic Vladisav Stefanovic 《Pathology, research and practice》2009
There is a high incidence of upper urothelial carcinoma (UUC) in regions affected by Balkan Endemic Nephropathy (BEN). The aim of this study was to compare E-cadherin expression in UUC, in regions affected by BEN, and in control rural and city populations free of BEN. Another aim was to determine the influence of some morphological parameters on the E-cadherin status. In the samples of 85 UUC patients, of whom 40 lived in BEN settlements and 45 served as control subjects, immunoreactions were performed using monoclonal anti-human E-cadherin antibody. Aberrant expression of E-cadherin was more frequent in BEN tumors than in control tumors (p<0.01). Decreased E-cadherin expression was linked to high grade and solid growth in control and BEN tumors (p<0.0001 and <0.05 versus p<0.05 and <0.05, respectively), and to the stage in control tumors (p<0.01). However, BEN low grade and low stage tumors showed aberrant expression more often than did control tumors (p<0.05 and <0.005, respectively). In control tumors, using univariate analysis, E-cadherin status was found to be influenced by grade, stage, and tumor growth (p=0.001, 0.017, 0.015, respectively). In the same group, only the grade was significant according to multistep logistic regression analysis (Wald=6.429 and p=0.011). The growth pattern had a predominant influence on E-cadherin expression in BEN tumors (p=0.005). A significant influence on normal membranous or abnormal cytoplasmic expression of E-cadherin in UUC is exerted by tumor grade, stage, growth, and metaplastic change (p=0.002, 0.048, 0.019, 0.011, respectively), but only by tumor grade in the multistep logistic regression model. These results suggest that decreased expression of E-cadherin in BEN tumors may be linked to tumor growth, while expression of E-cadherin in control tumors may be associated with tumor grade. 相似文献
166.
Gojnic M Dugalic V Milicevic S Arsenijevic Lj Popovic N Stefanovic A 《European journal of gynaecological oncology》2006,27(2):201-203
Vaginal melanomas account for fewer than 2% of vaginal malignancies. The mean age at diagnosis is 55 years and the prognosis is poor, with an overall 5-year survival rate of 5% to 10%. 相似文献
167.
Gojnic M Dugalic V Milicevic S Arsenijevic Lj Popovic N Stefanovic A 《European journal of gynaecological oncology》2006,27(2):147-149
At the Institute of Gynecology and Obstetrics over a period of five years, more than 180,000 women were examined; 580 simple and 178 radical vulvectomies were performed. 相似文献
168.
M Malesevic L Stefanovic S Popovic M Prvulovic Z Selir L Milkovic 《Radiobiologia, radiotherapia》1987,28(5):651-653
169.
J. Greffier J. Goupil A. Larbi X. Stefanovic F. Pereira G. Moliner S. Ovtchinnikoff J.P. Beregi J. Frandon 《Diagnostic and interventional imaging》2018,99(5):321-329
Purpose
To assess the value of the routine use of radiochromic films in abdominopelvic embolization procedures to improve patient follow-up.Methods
A total of 55 patients who underwent transcatheter abdominopelvic embolization were prospectively included. Six types of procedures were evaluated including hepatic chemoembolization (HCE), gonadal veins embolization (GVE), uterine elective embolization (UEE), uterine urgent embolization (UUE), abdominal elective embolization (AEE), and abdominal urgent embolization (AUE). Dosimetric indicators (DIs) such as air-kerma (AK) and kerma-area-product (KAP) were collected and peak skin dose (PSD) was measured with radiochromic films. Correlations between PSD and DIs were searched for.Results
The mean (±standard deviation [SD]) PSD for the various procedures were: 1033 ± 502 mGy for HCE; 476 ± 271 mGy for GVE; 460 ± 171 mGy for UEE; 531 ± 263 mGy for UUE; 708 ± 896 mGy for AEE; 683 ± 392 mGy for AUE. Strong correlations were observed between PSD and DIs (r = 0.974 for AK and r = 0.925 for KAP). PSD was > 2 Gy in one procedure and all procedures (7/132) procedures resulted in AK > 2 Gy, mostly for HCE and AEE.Conclusion
Dosimetry using radiochromic film is only appropriate for HCE, AEE and AUE, whereas dose-mapping systems present a more suitable solution for all embolizations including those with AK that occasionally exceed 2 Gy. 相似文献170.
Miljana Z Jovandaric Slobodanka Stefanovic Sandra Babic Svetlana J Milenkovic Ivana R Babovic 《The Journal of international medical research》2022,50(4)
Methicillin-resistant Staphylococcus epidermidis (MRS) predominantly colonizes the skin and mucous membranes of humans and other animals. We describe the case of a male newborn of gestational age 39 weeks whose primary and repeated blood cultures and cerebrospinal fluid samples isolated MRS. The choice and duration of antibiotic therapy were determined by the clinical presentation, infection parameters, and results of bacteriological analyses of blood and cerebrospinal fluid samples obtained from the newborn on the day 5 of life. After 28 days of antibiotic therapy for sepsis accompanied by meningitis, the newborn was discharged home without sequelae. 相似文献