Preliminary post-tsunami water quality survey in Phang-Nga province, southern Thailand

This preliminary water quality survey was performed eight weeks after the tsunami hit Phang-Nga Province on 26 December 2004. Water samples collected from the affected area, 10 km parallel to the seaside, were compared with water samples from the control area approximately 4 km from the seaside, which the tsunami waves could not reach. These samples included 18 surface-water samples, 37 well-water samples, and 8 drinking-water samples, which were examined for microbiology and physical-chemical properties. The microbiological examinations focused on enteric bacteria, which were isolated by culture method, while physical-chemical properties comprised on-site testing for pH, salinity, dissolved oxygen (DO), conductivity and total dissolved solids (TDS) by portable electrochemical meter (Sens Ion 156). The results of the microbiological examinations showed that water samples in the affected areas were more contaminated with enteric bacteria than the control area: 45.4% of surface-water samples in the affected area, and 40.0% in the control; 19.0% of well-water samples in the affected area, and 7.7% in the control. All eight drinking-water samples were clear of enteric bacteria. Tests for physical-chemical properties showed that the salinity, pH, conductivity, and TDS of surface-water samples from the affected area were significantly higher than the control. The salinity, conductivity, and TDS of the well-water samples from the affected areas were also significantly greater than those from the control area. The surface and well water in the tsunami-affected area have been changed greatly and need improvement.     

Current opinion on the regulation of small intestinal magnesium absorption

Magnesium (Mg²⁺) has an important role in numerous biological functions, and Mg²⁺ deficiency is associated with several diseases. Therefore, adequate intestinal absorption of Mg²⁺ is vital for health. The small intestine was previously thought to absorb digested Mg²⁺ exclusively through an unregulated paracellular mechanism, which is responsible for approximately 90% of total Mg²⁺ absorption. Recent studies, however, have revealed that the duodenum, jejunum, and ileum absorb Mg²⁺ through both transcellular and paracellular routes. Several regulatory factors of small intestinal Mg²⁺ uptake also have been explored, e.g., parathyroid hormone, fibroblast growth factor-23, apical acidity, proton pump inhibitor, and pH-sensing channel and receptors. The mechanistic factors underlying proton pump inhibitor suppression of small intestinal Mg²⁺, such as magnesiotropic protein dysfunction, higher mucosal bicarbonate secretion, Paneth cell dysfunction, and intestinal inflammation, are currently being explored. The potential role of small intestinal microbiomes in Mg²⁺ absorption has also been proposed. In this article, we reviewed the current knowledge on the mechanisms and regulatory factors of small intestinal Mg²⁺ absorption.