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排序方式: 共有1249条查询结果,搜索用时 41 毫秒
41.
Leonardi G Marchi S Falconi M Zerbi A Ussia V de Bortoli N Mosca F Presciuttini S Del Chiaro M 《Digestive and liver disease》2012,44(7):585-588
BackgroundPancPRO is a computer program that estimates the risk of pancreatic cancer for asymptomatic individuals based on a genetic model of susceptibility and the familial incidence of cancer.AimTo evaluate the distribution of the familial risk in a series of incident cases of pancreatic adenocarcinoma.Materials and methodsThe lifetime risk of pancreatic cancer was calculated by PancPro for a hypothetical 40-year-old son of 570 consecutive probands with pancreatic cancer.ResultsThe 570 risk values were included between 1% and 13%. The distribution was bimodal, with the antimode located at risk = 7.5%. Considering a 10-fold risk over the general population as a threshold for including a subject in a surveillance program, 19 families (3.3%) would be selected, totalling 92 first-degree relatives with age >40 years.ConclusionsPancPro is a valid instrument to rank families based on risk of pancreatic cancer. 相似文献
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Silvano Adami Luca Idolazzi Elena Fracassi Davide Gatti Maurizio Rossini 《骨研究(英文版)》2013,1(4):323-335
A number of effective therapies for the treatment of osteoporosis have become available in recent years. However, uncertainty exists regarding their long-term use and effectiveness. Bisphosphonate treatment, unlike hormone replacement, denosumab or teriparatide, is associated with benefits extended even after treatment discontinuation. The extended benefits are most apparent for alendronate (ALN) and zoledronate (ZOL). A drug holiday might be considered in patients at low-moderate risk and who have been fully compliant with treatment, and who have had a response to treatment. In patients at low-moderate risk of fractures the decision to consider a drug holiday should be balanced also with the safety profile of each treatment. 相似文献
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Neuroprotective Effects of Sulphated Agaran from Marine Alga Gracilaria cornea in Rat 6‐Hydroxydopamine Parkinson's Disease Model: Behavioural,Neurochemical and Transcriptional Alterations
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Ricardo Basto Souza Annyta Fernandes Frota Rayane Siqueira Sousa Nayara Araújo Cezario Tarcizio Brito Santos Luziana Mara Frota Souza Chistiane Oliveira Coura Valdécio Silvano Monteiro Gerardo Cristino Filho Silvânia Maria Mendes Vasconcelos Rodrigo Maranguape Silva da Cunha Lissiana Magna Vasconcelos Aguiar Norma Maria Barros Benevides 《Basic & clinical pharmacology & toxicology》2017,120(2):159-170
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Dragonieri S Schot R Mertens BJ Le Cessie S Gauw SA Spanevello A Resta O Willard NP Vink TJ Rabe KF Bel EH Sterk PJ 《The Journal of allergy and clinical immunology》2007,120(4):856-862
BACKGROUND: Exhaled breath contains thousands of volatile organic compounds (VOCs) that could serve as biomarkers of lung disease. Electronic noses can distinguish VOC mixtures by pattern recognition. OBJECTIVE: We hypothesized that an electronic nose can discriminate exhaled air of patients with asthma from healthy controls, and between patients with different disease severities. METHODS: Ten young patients with mild asthma (25.1 +/- 5.9 years; FEV(1), 99.9 +/- 7.7% predicted), 10 young controls (26.8 +/- 6.4 years; FEV(1), 101.9 +/- 10.3), 10 older patients with severe asthma (49.5 +/- 12.0 years; FEV(1), 62.3 +/- 23.6), and 10 older controls (57.3 +/- 7.1 years; FEV(1), 108.3 +/- 14.7) joined a cross-sectional study with duplicate sampling of exhaled breath with an interval of 2 to 5 minutes. Subjects inspired VOC-filtered air by tidal breathing for 5 minutes, and a single expiratory vital capacity was collected into a Tedlar bag that was sampled by electronic nose (Cyranose 320) within 10 minutes. Smellprints were analyzed by linear discriminant analysis on principal component reduction. Cross-validation values (CVVs) were calculated. RESULTS: Smellprints of patients with mild asthma were fully separated from young controls (CVV, 100%; Mahalanobis distance [M-distance], 5.32), and patients with severe asthma could be distinguished from old controls (CVV, 90%; M-distance, 2.77). Patients with mild and severe asthma could be less well discriminated (CVV, 65%; M-distance, 1.23), whereas the 2 control groups were indistinguishable (CVV, 50%; M-distance, 1.56). The duplicate samples replicated these results. CONCLUSION: An electronic nose can discriminate exhaled breath of patients with asthma from controls but is less accurate in distinguishing asthma severities. CLINICAL IMPLICATION: These findings warrant validation of electronic noses in diagnosing newly presented patients with asthma. 相似文献
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Ilenia Pisagatti Giuseppe Gattuso Anna Notti Melchiorre F. Parisi Giovanna Brancatelli Silvano Geremia Francesco Greco Salvatrice Millesi Andrea Pappalardo Luca Spitaleri Antonino Gulino 《RSC advances》2018,8(58):33269
Covalent bonding of 7-chloro-4-quinolylazo-octamethoxypillar[5]arene molecules to silylated quartz substrates readily produced a new chromogenic reusable pillararene-coated quartz slide, for the direct UV detection of “transparent” analytes in solution. This device provides an analyte-selective optical response towards linear (di)amines with a highly reproducible optical read-out.Pillar[5]arene-decorated quartz slides for the direct detection of linear amines and diamines are now available. 相似文献
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Pierre Ct Hainan Yu Heather M. Shearer Kristi Randhawa Jessica J. Wong Silvano Mior Arthur Ameis Linda J. Carroll Margareta Nordin Sharanya Varatharajan Deborah Sutton Danielle Southerst Craig Jacobs Maja Stupar Anne Taylor‐Vaisey Douglas P. Gross Robert J. Brison Mike Paulden Carlo Ammendolia J. David Cassidy Patrick Loisel Shawn Marshall Richard N. Bohay John Stapleton Michel Lacerte 《European Journal of Pain》2019,23(6):1051-1070