全文获取类型
收费全文 | 3050篇 |
免费 | 230篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 51篇 |
儿科学 | 80篇 |
妇产科学 | 35篇 |
基础医学 | 455篇 |
口腔科学 | 31篇 |
临床医学 | 314篇 |
内科学 | 533篇 |
皮肤病学 | 89篇 |
神经病学 | 403篇 |
特种医学 | 154篇 |
外科学 | 285篇 |
综合类 | 37篇 |
一般理论 | 2篇 |
预防医学 | 225篇 |
眼科学 | 54篇 |
药学 | 270篇 |
中国医学 | 8篇 |
肿瘤学 | 261篇 |
出版年
2023年 | 23篇 |
2022年 | 57篇 |
2021年 | 89篇 |
2020年 | 56篇 |
2019年 | 69篇 |
2018年 | 79篇 |
2017年 | 63篇 |
2016年 | 83篇 |
2015年 | 104篇 |
2014年 | 106篇 |
2013年 | 178篇 |
2012年 | 235篇 |
2011年 | 209篇 |
2010年 | 124篇 |
2009年 | 130篇 |
2008年 | 235篇 |
2007年 | 187篇 |
2006年 | 199篇 |
2005年 | 199篇 |
2004年 | 181篇 |
2003年 | 136篇 |
2002年 | 125篇 |
2001年 | 42篇 |
2000年 | 52篇 |
1999年 | 32篇 |
1998年 | 24篇 |
1997年 | 22篇 |
1996年 | 18篇 |
1995年 | 13篇 |
1994年 | 13篇 |
1993年 | 14篇 |
1992年 | 17篇 |
1991年 | 8篇 |
1990年 | 15篇 |
1989年 | 10篇 |
1988年 | 8篇 |
1987年 | 12篇 |
1986年 | 10篇 |
1985年 | 15篇 |
1984年 | 15篇 |
1983年 | 11篇 |
1982年 | 8篇 |
1981年 | 8篇 |
1979年 | 4篇 |
1978年 | 7篇 |
1977年 | 5篇 |
1973年 | 3篇 |
1971年 | 4篇 |
1968年 | 4篇 |
1967年 | 3篇 |
排序方式: 共有3287条查询结果,搜索用时 15 毫秒
61.
B. Silke S. P. Verma S. Guy 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》1991,5(4):681-687
The hemodynamic consequences of blockade at both beta-adrenoceptors and slow calcium channels is of therapeutic importance for patients with angina pectoris. The hemodynamic interaction of a new cardioselective beta blocker, celiprolol, and nifedipine was examined in an acute hemodynamic study using three prospectively matched groups with angiographically confirmed coronary artery disease (n = 10/group). Patients were randomly allocated to intravenous celiprolol (8 mg), sublingual nifedipine (20 mg), or their combination. Rest and exercise (supine bicycle) hemodynamics were determined before and following each therapy. At rest, celiprolol did not alter pumping function; nifedipine reduced diastolic blood pressure and systemic vascular resistance index (SVRI), with a small increase in heart rate. Combination therapy reduced systemic arterial pressure and SVRI; heart rate and cardiac stroke volume index increased. During exercise celiprolol tended to reduce heart rate and cardiac index; nifedipine reduced exercise SVR and cardiac stroke work indices. Combination therapy reduced all components of blood pressure; cardiac stroke work and SVR indices fell. These hemodynamic data suggest that beta blockade with celiprolol may result in a slight depression of cardiac pumping during exercise; however, such effects are offset by the vasodilating actions of nifedipine (reflex sympathetic action offsetting cardiodepression). Thus the acute hemodynamic effects of this combination were seemingly safe in these patients; the longer term effects during maintained therapy should be further assessed. 相似文献
62.
Association between Lp-PLA2 and coronary artery disease: focus on its relationship with lipoproteins and markers of inflammation and hemostasis 总被引:7,自引:0,他引:7
Khuseyinova N Imhof A Rothenbacher D Trischler G Kuelb S Scharnagl H Maerz W Brenner H Koenig W 《Atherosclerosis》2005,182(1):181-188
Lipoprotein-associated phospholipase A2 (Lp-PLA2) generates pro-inflammatory molecules from oxidized LDL. We examined the association between Lp-PLA2 plasma concentrations and risk of stable coronary artery disease (CAD) in a large case-control study and further assessed the relationship between Lp-PLA2 and various lipid, inflammatory and hemostatic parameters. Lp-PLA2 concentrations were measured in 312 patients with CAD and in 479 age- and gender-matched blood donors. Various sensitive inflammatory and hemostatic markers and a complete lipoprotein profile were obtained. Lp-PLA2 concentrations were significantly higher in cases than in controls (296.1 ng/mL versus 266.0 ng/mL, p<0.0001). In multivariable logistic regression, the age- and gender-adjusted OR for the presence of CAD was 1.61 (95% CI, 1.07-2.44) if the top quartile of the Lp-PLA2 distribution was compared to the bottom quartile. Adjustment for traditional cardiovascular risk factors and statin use resulted in an OR of 2.04 (95% CI, 1.19-3.48). After additional controlling for vWF, the OR was slightly attenuated but still remained statistically significant (OR 1.91; 95% CI, 1.12-3.28). Thus, elevated Lp-PLA2 concentrations were associated with the presence of stable CAD, independent of various biochemical markers. Our results support the hypothesis that Lp-PLA2 may be a novel, independent risk marker for CAD. 相似文献
63.
64.
65.
Kristen Rak Johannes Völker Silke Frenz Agmal Scherzed Andreas Radeloff Rudolf Hagen Robert Mlynski 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2013,226(3):393-406
Neuronal stem cells have been described in the post-natal cochlear nucleus recently. The aim of the study was to analyse the neurogenic potential in the cochlear nucleus from the early post-natal days until adulthood. Cochlear nuclei from Sprague–Dawley rats from post-natal day P3 up to P40 were examined. Neurosphere assays showed persistent neurosphere formation from the early post-natal days until adulthood. The numbers of generated neurospheres were fewer in older ages. Neurospheres were smaller, but displayed the same pattern of neuronal stem cell markers. The markers GFAP, MBP and ß-III Tubulin showed differentiation of dissociated cells from the neurospheres in all cells of the neuronal lineage. BrdU incorporation could be detected, in an age-dependent decrease, in whole-mount experiments of the cochlear nucleus on all examined days. BrdU co-labelled with Atoh1 and ß-III Tubulin. In addition, gene expression and cellular distribution studies of the neuronal stem cell markers displayed an age-dependent reduction in both quantity and numbers. The presented results display a possible neurogenic potential until adulthood in the cochlear nucleus by in vitro and in vivo experiments. The fact that this potential is highest at a critical period of development reveals possible functional importance for the development of the cochlear nucleus and the auditory function. The persistent neurogenic potential displayed until adulthood could be a neurogenic niche in the adult cochlear nucleus, which might be used for potential therapeutic strategies. 相似文献
66.
Michaud Katarzyna Magnin Virginie Faouzi Mohamed Fracasso Tony Aguiar Diego Dedouit Fabrice Grabherr Silke 《International journal of legal medicine》2021,135(5):1829-1836
International Journal of Legal Medicine - Sudden cardiac death (SCD) related to atherosclerotic coronary artery disease (ACAD) resulting in myocardial infarction is the most prevalent cause of... 相似文献
67.
68.
Klemens Horst Silke Ganzera Wolfgang Kaisers Johanna Munding Berenike Flott-Rahmel Andrea Tannapfel Hubert Zirngibl 《Pathology, research and practice》2013
The MRE11/RAD50/NIBRIN complex, a protein complex that repairs DNA double-strand breaks, could serve as an early marker for new lesions in pancreatic cancer. We determined the expression of MRE11, RAD50 and NIBRIN, and their possible prognostic value regarding survival. 相似文献
69.
Melanie Fhrenbach Rami Abou Jamra Arndt Borkhardt Triantafyllia Brozou Petra Muschke Bernt Popp Linda K. Rey Jrg Schaper Harald Surowy Martin Zenker Christiane Zweier Dagmar Wieczorek Silke Redler 《Clinical genetics》2021,99(1):199-207
Ververi‐Brady syndrome (VBS, # 617982) is a rare developmental disorder, and loss‐of‐function variants in QRICH1 were implicated in its etiology. Furthermore, a recognizable phenotype was proposed comprising delayed speech, learning difficulties and dysmorphic signs. Here, we present four unrelated individuals with one known nonsense variant (c.1954C > T; p.[Arg652*]) and three novel de novo QRICH1 variants, respectively. These included two frameshift mutations (c.832_833del; p.(Ser278Leufs*25), c.1812_1813delTG; p.(Glu605Glyfs*25)) and interestingly one missense mutation (c.2207G > A; p.[Ser736Asn]), expanding the mutational spectrum. Enlargement of the cohort by these four individuals contributes to the delineation of the VBS phenotype and suggests expressive speech delay, moderate motor delay, learning difficulties/mild ID, mild microcephaly, short stature and notable social behavior deficits as clinical hallmarks. In addition, one patient presented with nephroblastoma. The possible involvement of QRICH1 in pediatric cancer assumes careful surveillance a key priority for outcome of these patients. Further research and enlargement of cohorts are warranted to learn about the genetic architecture and the phenotypic spectrum in more detail. 相似文献
70.
Laura Kropp Anish Baswanth Chakka Svetlana Yatsenko Eleonora Di Gregorio Daniela Lacerenza Giovanna Vaula Flavia Talarico Paola Mandich Camilo Toro Eleonore Eymard Pierre Pierre Labauge Sabina Capellari Pietro Cortelli Filippo Pinto Vairo Diego Miguel Danielle Stubbolo Lourenco Charles Marques William Gahl Odile Boespflug‐Tanguy Atle Melberg Sharon Hassin‐Baer Oren S. Cohen Rastislav Pjontek Armin Grau Thomas Klopstock Brent Fogel Inge Meijer Guy Rouleau Jean‐Pierre L. Bouchard Madhavi Ganapathiraju Adeline Vanderver Niklas Dahl Grace Hobson Alfredo Brusco Quasar Saleem Padiath 《Human mutation》2013,34(8):1160-1171
Autosomal dominant leukodystrophy (ADLD) is an adult onset demyelinating disorder that is caused by duplications of the lamin B1 (LMNB1) gene. However, as only a few cases have been analyzed in detail, the mechanisms underlying LMNB1 duplications are unclear. We report the detailed molecular analysis of the largest collection of ADLD families studied, to date. We have identified the minimal duplicated region necessary for the disease, defined all the duplication junctions at the nucleotide level and identified the first inverted LMNB1 duplication. We have demonstrated that the duplications are not recurrent; patients with identical duplications share the same haplotype, likely inherited from a common founder and that the duplications originated from intrachromosomal events. The duplication junction sequences indicated that nonhomologous end joining or replication‐based mechanisms such fork stalling and template switching or microhomology‐mediated break induced repair are likely to be involved. LMNB1 expression was increased in patients’ fibroblasts both at mRNA and protein levels and the three LMNB1 alleles in ADLD patients show equal expression, suggesting that regulatory regions are maintained within the rearranged segment. These results have allowed us to elucidate duplication mechanisms and provide insights into allele‐specific LMNB1 expression levels. 相似文献