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51.
Background
Individuals with mental disorders have increased rates of obesity and metabolic syndrome. Here we evaluated factors influencing obesity in individuals with mental disorders who were attending psychiatric day-care facilities on an outpatient basis.Methods
The subjects (n = 108) were outpatients attending hospital-based rehabilitation programs. We assessed body fat, weight, height, waist circumference, body mass index (BMI), blood pressure, Geriatric Depression Scale-15 (GDS) scores, frequency of day-care visits, satisfaction with body shape, physical comorbidity and lifestyle habits. Lifestyle habits were evaluated using Breslow''s health index based on health-related choices.Results
The subjects were divided into 2 groups: obese group (BMI ≥ 25 kg/m2) and non-obese group (BMI < 25 kg/m2). The physical parameters and attributes of both groups were compared, and factors related to BMI were statistically analyzed. The prevalence of obesity was 47.2% in all patients, 42.4% in males and 54.8% in females. Weight, waist circumference, body fat and systolic and diastolic blood pressure were significantly higher in the obese group than in the non-obese group. Body fat, waist circumference, systolic blood pressure and diastolic blood pressure exhibited significant positive correlations with BMI, whereas the frequency of day-care visits, satisfaction with body shape, GDS score and Breslow''s health index exhibited significant negative correlations with BMI.Conclusion
The present results showed that the prevalence of obesity was high in outpatients with mental disorders. Improvement in lifestyle choices is necessary to prevent obesity and the onset of metabolic syndrome in such patients. 相似文献52.
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Osaki S Nakanishi Y Andou K Takano K Takayama K Hirota N Ishibashi T Hara N 《Respirology (Carlton, Vic.)》2002,7(1):83-85
A 49-year-old man with diabetes mellitus and alcoholic liver cirrhosis presented with dyspnoea and fever. A chest computed tomography scan revealed three areas of loculated pleural effusion. Initially, the patient was thought to have an intrapleural empyema and was treated with intravenous antibiotics and closed drainage. However, as he did not improve, he was then treated with open drainage. During open drainage, the patient was diagnosed to have an extrapleural empyema and improved following open drainage treatment. 相似文献
57.
Microsatellite instability in gallbladder carcinoma: two independent genetic pathways of gallbladder carcinogenesis 总被引:10,自引:0,他引:10
Yoshida T Sugai T Habano W Nakamura S Uesugi N Funato O Saito K 《Journal of gastroenterology》2000,35(10):768-774
Although the genetic basis for gallbladder carcinogenesis has not been clarified, considerable evidence has shown that genetic
alterations play an important role in the development and progression of human cancers. In this study, we analyzed 30 gallbladder
carcinomas to investigate the role of genetic alterations in their tumorigenesis, and to study correlations with their clinicopathological
features. Tissue samples were obtained from 30 patients with gallbladder carcinoma (11 men and 19 women; mean age, 62 years;
age range, 38–80 years). Genomic DNAs were extracted from fresh tumor tissue. We examined loss of heterozygosity (LOH) in
the p53, APC, DCC, RB, and NM23-H1 gene regions by polymerase chain reaction (PCR)-LOH assay using an automated fluorescent DNA sequencer employing four microsatellite
markers (p53, APC, DCC, NM23-H1). Five additional microsatellite markers were used for the determination of microsatellite
instability (MSI). LOH was found at p53 in 9 of 15 informative cases (60%), at DCC in 10 of 22 (45%), at APC in 5 of 15 (33%), at RB in 1 of 8 (13%), and at NM23-H1 in 1 of 15 (7%). MSI was observed in 5 of 30 cases (17%) in at least one chromosomal loci of these nine microsatellite markers.
None of the patients with MSI-positive tumors showed lymph node metastasis, and there was an inverse correlation between MSI
and the presence of LOH in gallbladder carcinoma. These results suggest that there are two independent genetic pathways in
gallbladder carcinogenesis; that is, an MSI pathway and an LOH pathway.
Received: December 24, 1999 / Accepted: May 26, 2000 相似文献
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Nakano H Kikuchi K Seta S Katayama M Horikoshi K Yamamura T Otsubo T 《Hepato-gastroenterology》2005,52(66):1883-1885
Identifying anatomical variations of the celio-mesenteric arterial branches is important when performing pancreaticoduodenectomy. A relatively rare variation is the common hepatic artery entirely originated as a branch of the superior mesenteric artery. This type of variation is termed hepatomesenteric trunk type common hepatic artery, in which an accessory left hepatic artery arising from the celiac trunk is absent. Preservation of hepatomesenteric trunk type common hepatic artery is indispensable during pancreaticoduodenectomy because fatal hepatic injury or leak of hepaticojejunostomy can occur. The present case report shows a patient with pancreatic head tumor in whom hepatomesenteric trunk type common hepatic artery was involved by the tumor. The patient underwent pancreaticoduodenectomy during which the involved hepatomesenteric type common hepatic artery was removed and reconstructed using saphenous venous grafts. Histopathological examination showed double cancers which were composed of an advanced ductal adenocarcinoma of the pancreas and early bile duct adenocarcinoma. The patient is alive 18 months after the surgery without recurrence. 相似文献