全文获取类型
收费全文 | 2359篇 |
免费 | 42篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 91篇 |
儿科学 | 34篇 |
妇产科学 | 19篇 |
基础医学 | 380篇 |
口腔科学 | 51篇 |
临床医学 | 134篇 |
内科学 | 422篇 |
皮肤病学 | 43篇 |
神经病学 | 173篇 |
特种医学 | 64篇 |
外科学 | 442篇 |
综合类 | 13篇 |
预防医学 | 42篇 |
眼科学 | 35篇 |
药学 | 227篇 |
中国医学 | 5篇 |
肿瘤学 | 232篇 |
出版年
2023年 | 4篇 |
2022年 | 8篇 |
2021年 | 34篇 |
2020年 | 20篇 |
2019年 | 19篇 |
2018年 | 28篇 |
2017年 | 23篇 |
2016年 | 25篇 |
2015年 | 26篇 |
2014年 | 50篇 |
2013年 | 84篇 |
2012年 | 134篇 |
2011年 | 159篇 |
2010年 | 82篇 |
2009年 | 94篇 |
2008年 | 128篇 |
2007年 | 167篇 |
2006年 | 168篇 |
2005年 | 184篇 |
2004年 | 177篇 |
2003年 | 201篇 |
2002年 | 184篇 |
2001年 | 36篇 |
2000年 | 22篇 |
1999年 | 32篇 |
1998年 | 50篇 |
1997年 | 39篇 |
1996年 | 34篇 |
1995年 | 33篇 |
1994年 | 28篇 |
1993年 | 16篇 |
1992年 | 13篇 |
1991年 | 14篇 |
1990年 | 13篇 |
1989年 | 15篇 |
1988年 | 7篇 |
1987年 | 10篇 |
1986年 | 3篇 |
1985年 | 10篇 |
1984年 | 5篇 |
1983年 | 6篇 |
1982年 | 3篇 |
1981年 | 2篇 |
1980年 | 5篇 |
1978年 | 3篇 |
1967年 | 1篇 |
1965年 | 1篇 |
1961年 | 1篇 |
1926年 | 1篇 |
1925年 | 1篇 |
排序方式: 共有2407条查询结果,搜索用时 15 毫秒
41.
Yasushi Rino Munetaka Masuda Norio Yukawa Hitoshi Murakami Ken Takata Tsutomu Hayashi Shin-ichi Suzuki Kei-ichiro Kasama Toshio Imada 《Esophagus》2010,7(1):71-74
In this report, we describe our traction suture technique of the pericardium for suspension of the heart without hemodynamic
instability to obtain excellent exposure in the abdominal-transhiatal approach (TH). Our technique is an application of deep
pericardium stitches for off-pump coronary artery bypass surgery. In detail, the left hepatic lobe is detached at its triangular
ligament from the diaphragm and is deflected to the right. Then, the tendinous portion of the diaphragm arching over the esophagus
is incised upward in the midline until the pericardium is exposed. Pericardial fatty tissue was dissected. Three U-shaped
sutures reinforced with a felt pledget are placed on the posterior aspect of the pericardium and diaphragm. A 15 Fr. flexible
catheter is placed over both ends of the suture to avoid damage of the adjacent organs. Finally, the sutures are fixed to
the drape of anterior wall of the patient to maintain good exposure. 相似文献
42.
Osamu Kitamura Toshiaki Takeichi Elaine Lu Wang Itsuo Tokunaga Akiko Ishigami Shin-ichi Kubo 《Legal medicine (Tokyo, Japan)》2010,12(2):57-62
Little is known about the role of glial cells in the striatum of chronic methamphetamine (METH) users. In this study, we immunohistochemically examined glial reactions in the striatum of chronic METH users who did not abstain from METH use and died of drug intoxication. Human glucose transporter 5 (hGLUT), a useful marker of microglia, and CR3.43, a major histocompatibility complex class II antigen specific for reactive microglia, were immunostained. Glial fibrillary acidic protein (GFAP) and S100Β were used for astrocyte immunohistochemistry. We analyzed 12 chronic METH users and 13 control subjects, and detected a 200–240% increase in the number of hGLUT5-positive cells in chronic METH users (p < 0.01). However, we did not detect any proliferation of CR3.43-positive cells. The number of GFAP-positive astrocytes increased, but this increase was not significant (p > 0.05). Moreover, S100B-positive cell density between the two groups was not significant (p > 0.05). This study demonstrates the absence of reactive gliosis in the striatum of chronic METH users who did not abstain for prolonged periods from METH use. The results suggest that chronic METH use by itself did not activate glial cells in humans and reactive gliosis may not be involved in the mechanism underlying the loss of control in drug intake, which is a characteristic feature of drug addiction. 相似文献
43.
Shin-ichi Ando Keita Odashiro Toshiaki Ashihara Hiroshi Ando Wataru Mitsuoka Hirofumi Tagawa Takaya Fukuyama 《Heart and vessels》1994,9(2):104-107
Summary We angiographically documented coronary vasospasm which resulted in myocardial infarction during the acute phase of aortic dissection (Stanford A). Coronary and aortic angiography performed at admission of the patient revealed complete occlusion of the right coronary artery and dissection of the aorta. Intracoronary injection of isosorbide dinitrate and intravenous administration of verapamil opened the occluded right coronary artery and blood flow was fully restored. We conclude that, in this case of aortic dissection, the severe stimulation by the aortic dissection brought about vasospasm of the right coronary artery which was the major cause of myocardial infarction. This is the first case report showing clear evidence that myocardial infarction is brought about by vasospasm associated with aortic dissection. 相似文献
44.
45.
Fumiki Yoshihara Toshio Nishikimi Yoshikado Sasako Jun Hino Junjiro Kobayashi Kenji Minatoya Ko Bando Yoshio Kosakai Takeshi Horio Shin-ichi Suga Yuhei Kawano Hiroaki Matsuoka Chikao Yutani Hisayuki Matsuo Soichiro Kitamura Tohru Ohe Kenji Kangawa 《Journal of the American College of Cardiology》2002,39(2):288-294
OBJECTIVES: We hypothesized that the plasma atrial natriuretic peptide (ANP) level reflects atrial degenerative change and may predict the outcome of the maze procedure. BACKGROUND: Although a larger preoperative left atrial dimension and longer duration of atrial fibrillation (AF) have been reported in patients with persistent AF than in those with sinus rhythm (SR), these individual factors were not enough to predict the outcome of the maze procedure. METHODS: Preoperative plasma ANP levels were measured in consecutive 62 patients who underwent the Kosakai's modified maze procedure. Moreover, we performed histological and molecular biological examinations in the resected left atrial tissues. RESULTS: The preoperative plasma ANP was lower in the AF group (n = 13) than it was in the SR group (n = 49) (p < 0.001). Multiple logistic regression analysis revealed that duration of AF and plasma ANP were independently associated with postoperative cardiac rhythm. Among 41 patients with a higher plasma ANP or shorter duration of AF than the median value, SR was restored in 95% of patients. In contrast, in 21 patients with a lower plasma ANP and a longer duration of AF than the median value, SR was restored only in 48% of patients. Histological examination revealed that the collagen volume in the left atrial tissue was higher in AF than it was in SR and inversely correlated with plasma ANP. In addition, the messenger RNA expressions of ANP, collagen type I and type III were lower in AF than they were in SR. CONCLUSIONS: These results suggest that a combination of plasma ANP and/or duration of AF may predict the success rate for the maze operation. Advanced atrial degenerative change may result in a decrease of atrial ANP secretion. 相似文献
46.
Shin-ichi Nunoda M.D. Naonori Mimo M.D. Hirotsugu Kitano M.D. Masanori Kyoi M.D. Senshu Hifumi M.D. Toshio Ueno M.D. Ryoyu Takeda M.D. Yasuni Nakanuraa M.D. 《The American journal of gastroenterology》1983,78(5):301-304
We describe a case of hepatocellular carcinoma in a 16-year-old boy whose mother, aunts, uncles, and cousins had liver dysfunction associated with HBs-Ag. Postmortem examination in this case revealed a hepatocellular carcinoma with a trabecular and partially pseudoglandular pattern involving the whole left and most of the right lobe, associated with liver cirrhosis of the postnecrotic type. Postmortem examination of the liver revealed numerous HBs-Ag positive hepatocytes demonstrated by Orcein staining in the nontumorous cirrhotic area, but not in the tumorous hepatocytes. Vertical transmission of HBV from his mother to the patient was suspected, and autopsy findings revealed continuous infection of HBV. Hepatocellular carcinoma in a young patient, especially when associated with HBs-Ag positive liver cirrhosis, as described here is rare in the English and Japanese literature. 相似文献
47.
A 56-year-old Japanese man with hypertension presented with a 10 days history of high fever, right and left upper quadrant tenderness. An abdominal ultrasonography and computerized tomographic scan revealed a large collection in the right lobe of the liver that was consistent with an abscess. A drainage catheter was placed and purulent fluid was drained. Cultures of the fluid and blood were positive for a strain of ampicillin-resistant Klebsiella pneumoniae. Six days after admission, paraplegia and urinary retention were found. On the neurological examination, deep tendon reflexes of the lower extremities were absent bilaterally. Magnetic resonance imaging scan detected thoracic spinal epidural abscess and paraspinal abscess. He received the emergent decompressive laminectomy. Culture of surgical specimen grew ampicillin-resistant K. pneumoniae. The patient was treated with biapenem intravenously. Thereafter, clinical symptoms improved gradually and he was removed to the professional hospital to continue rehabilitation for gait disturbance on hospital day 147. 相似文献
48.
Association of hyperadiponectinemia with severity of ventricular dysfunction in congestive heart failure. 总被引:5,自引:0,他引:5
Tomohiro Nakamura Hiroshi Funayama Norifumi Kubo Takanori Yasu Masanobu Kawakami Muneyasu Saito Shin-ichi Momomura San-E Ishikawa 《Circulation journal》2006,70(12):1557-1562
BACKGROUND: Adiponectin, which is a collagen-like plasma protein produced by adipose tissue, has anti-atherogenic and anti-inflammatory effects. Plasma adiponectin levels in patients with congestive heart failure (CHF) were determined, as well as relationships between the plasma levels of adiponectin and other hormones. METHODS AND RESULTS: The study group comprised 90 patients with CHF and 20 control subjects, who were divided into 4 subgroups according to New York Heart Association (NYHA) functional class. Plasma levels of adiponectin, tumor necrosis factor (TNF)-alpha and brain natriuretic peptide (BNP) and cardiac hemodynamics were determined. Plasma adiponectin levels were significantly increased according to the severity of NYHA class in the patients with CHF; control: 6.2+/-1.0; NYHA I: 8.5+/-1.9, NYHA II: 12.0+/-2.2, NYHA III: 13.0+/-2.7, NYHA IV: 14.9+/-2.7 microg/ml (p=0.0008). Similarly, plasma BNP levels were significantly increased in accordance with the NYHA class. Plasma adiponectin levels correlated positively with BNP (r=0.40, p=0.0002) and TNF-alpha (r=0.49, p=0.0001), and correlated negatively with cardiac index (r=-0.27, p=0.05). In 24 of 46 patients in the NYHA III and IV subgroups, according to the prompt improvement in cardiac function, levels of both plasma adiponectin and BNP were significantly reduced (p<0.0001). CONCLUSION: Plasma adiponectin levels increased according to the severity of CHF and, moreover, they correlated with the plasma levels of BNP and TNF-alpha. These results indicate that augmented release of adiponectin is involved in the pathogenesis of CHF and further study is needed to elucidate its exact role. 相似文献
49.
Tatsuo?KandaEmail author Tsutomu?Suzuki Shin-ichi?Kosugi Masato?Nakano Takashi?Ishikawa Satoru?Nakagawa Katsuyoshi?Hatakeyama 《Esophagus》2004,1(3):131-134
We present a case of esophageal carcinoma in which esophagectomy was not possible because of tuberculous fibrosing mediastinitis. A 77-year-old man was diagnosed with carcinoma of the thoracic esophagus and admitted to our hospital. Chest radiography on admission revealed no abnormality except pleural thickening of the pulmonary apices, suggesting a history of subclinical infection of tuberculous pleurisy. The patient underwent surgery with a curative intent. Thoracotomy revealed that the mediastinum had been replaced with dense fibrous tissues and was widely encased with laminar calcification. Esophagectomy was not performed because it was considered impossible to do so safely. Although diagnosis of fibrous mediastinitis was not made preoperatively, review of the preoperative computed tomographic scans revealed proliferation of mediastinal soft tissues that were associated with patchy and laminar calcifications. Tuberculous fibrosing mediastinitis is an uncommon but clinically important disease for physicians who are involved in the diagnosis and treatment of esophageal cancer. 相似文献
50.
Shunsuke Koseki Takamasa Noda Satoshi Yokoyama Yoshihiko Kunisato Daisuke Ito Haruna Suyama Taro Matsuda Yuji Sugimura Naoko Ishihara Yu Shimizu Kanako Nakazawa Sumiko Yoshida Kunimasa Arima Shin-ichi Suzuki 《Journal of affective disorders》2013