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91.
Shigeo Tazuke Takeshi Okada Seizo Okamura 《Macromolecular chemistry and physics.》1968,115(1):213-222
Thermal rate of polymerization of 4-vinylpyridine (4-VP) was found to increase greatly in the presence of zinc acetate. The occurrence of radical polymerization was confirmed by studying the effects of additives (2.2-diphenyl-1-picrylhydrazyI (DPPH), air and water). Using zinc acetate as catalyst in THF, the order of thermal rate was 4-VP > MVP > 2-VP (no polymerization). It was concluded that the enhancement of the rate of thermal polymerization was not only due to the increase of propagation rate but also due to the thermal production of radicals by the interaction between monomer and metal salts. The influence of zinc salts on the electronic state of vinylpyridines was studied by electronic spectroscopy. The π→π* transition band of 4-VP was observed to shift towards lower energy by complexing the monomer. The amounts of shift of 2-metlyl-5-vinylpyridine (MVP) and 2-vinylpyridine (2VP) were much smaller than those of the 4-VP-complexes. These spectral data were discussed on the basis of the electornic interction of metal ion with ligand as well as the steric effect in complex formation, and were correlated to the thermal polymerizabilities of complexed vinylpyridines. 相似文献
92.
93.
Lack of association between DNA base excision repair gene XRCC1 Gln399Arg polymorphism and risk of malignant lymphoma in Japan 总被引:2,自引:0,他引:2
Matsuo K Hamajima N Suzuki R Andoh M Nakamura S Seto M Morishimae Y Tajima K 《Cancer Genetics and Cytogenetics》2004,149(1):77-80
Growing evidence suggests that the polymorphism of DNA base excision repair gene XRCC1 Arg399Gln is associated with altered DNA repair proficiency and subsequent cancer susceptibility; however, no evidence is available for malignant lymphoma. We therefore conducted a case-control study (372 cases, 500 controls) to evaluate links with malignant lymphoma risk in Japan. The risk was evaluated in terms of odds ratio (OR) and 95% confidence interval (CI) adjusted for age and sex in an unconditional logistic regression model. There was no statistical risk change with the Arg/Gln (adjusted OR 0.89; 0.65-1.23, P = 0.492) or the Gln/Gln (0.57; 0.27-1.17, P = 0.127) compared with the Arg/Arg of the XRCC1 Arg399Gln polymorphism. The results were unchanged in analyses according to histological subtype (diffuse large lymphoma, follicular lymphoma, low-grade lymphoma of mucosa-associated lymphoid tissue, and others). These data suggest that XRCC1 Gln399Arg polymorphism plays a limited role in lymphomagenesis. Further study on the interaction between the polymorphism and environmental exposure is required. 相似文献
94.
Taki Y Goto R Evans A Zijdenbos A Neelin P Lerch J Sato K Ono S Kinomura S Nakagawa M Sugiura M Watanabe J Kawashima R Fukuda H 《Neurobiology of aging》2004,25(4):455-463
The objectives of this study were to evaluate the correlations of the volumes of the gray matter and white matter with age, and the correlations of the tissue probabilities of the gray matter and white matter with age and several cerebrovascular risk factors. We obtained magnetic resonance (MR) images of the brain and clinical information from 769 normal Japanese subjects. We processed the MR images automatically by correcting for inter-individual differences in brain size and shape, and by segmenting the MR images into the gray matter and white matter. Volumetry of the brain revealed a significant negative correlation between the gray matter volume and age, which was not observed between white matter volume and age. Voxel-based morphometry showed that age, systolic blood pressure, and alcohol drinking correlated with the regional tissue probabilities of the gray matter and white matter. 相似文献
95.
Yasuo Saegusa Minoru Kuriki Shigeo Nakamura 《Macromolecular chemistry and physics.》1994,195(5):1877-1889
A series of novel fluorine-containing aromatic homopolyazomethines and copolyazomethines were synthesized by solution polycondensation of perfluoroisopropylidene (perfluoropropane-2,2-diyl) group-containing aromatic diamines, 2,2-bis[4-(4-aminophenoxy)phenyl]-1,1,1,3,3,3-hexafluoropropane (4,4′-[1,1,1,3,3,3-hexafluoropropane-2,2-diylbis(1,4-phenyleneoxy)]dianiline ( 1a )) and 2,2-bis(4-aminophenyl)-1,1,1,3,3,3-hexafluoropropane (4,4′-(1,1,1,3,3,3-hexafluoropropane-2,2-diyl)dianiline ( 1b )), and/or the corresponding analogous isopropylidene group-containing aromatic diamines, 2,2-bis[4-(4-aminophenoxy)phenyl]propane (4,4′-[isopropylidenebis(1,4-phenyleneoxy)]dianiline ( 1c )) and 2,2-bis(4-aminophenyl)propane (4,4′-isopropylidenedianiline ( 1d )), with terephthalaldehyde ( 2a ) and isophthaladehyde ( 2b ). The effect of fluorine substitution on the synthesis and properties of these polymers was investigated by comparison with those of the corresponding homopolyazomethines but without fluorine. Film-forming fluorine-containing polyazomethines with reduced viscosities up to ηred = 0,44 dL · g?1 were obtained in high yields by using m-cresol as reaction medium. Incorporation of perfluoroisopropylidene groups in the polyazomethine backbone greatly enhanced the solubility of the polymers in various organic solvents including chloroform and tetrahydrofuran. Their thermal stability was also successfully improved by the introduction of fluorine, and both the temperatures of 5% and 10% weight loss in air increased monotonically with the increase of the fluorine content. The surface properties of the films or the contact angles formed by water and diiodomethane were, however, scarcely affected by fluorine substitution. The mechanical properties of the films, such as tensile strength and initial modulus, fairly decreased by the modification. 相似文献
96.
The surgically excised stomachs were re-examined histopathologically, and eighteen cases were placed in the category of reactive lymphoid hyperplasia (RLH). The distribution and the classes of infiltrating immunoglobulin (Ig) bearing cells were examined on lesions of RLH cases together with ten histopathologically determined malignant lymphomas (ML) of the stomach and the control stomachs. It was found that in eleven cases of RLH and one case of ML, many lymphoid cells bearing different classes of Ig were present in those lesions in an intermingled way (polyspecific group). Meanwhile, lymphoid cells in three RLH cases and two ML cases bore only a single mono-specific Ig (monospecific group). In other cases, the number of Ig bearing cells were not sufficient to reach any clear conclusions (undetermined group). It was speculated that regardless of the histopathological diagnosis, the mono-specific group might belong to the category of neoplasm of B cell type and the polyspecific group in the category of true reactive process. The possible histopathological criteria for differentiation of the reactive process and lymphoid neoplasm of the stomach were re-checked, and the importance of immunohistochemical study on these cases were stressed. 相似文献
97.
Porphyromonas gingivalis Fimbriae Use β2 Integrin (CD11/CD18) on Mouse Peritoneal Macrophages as a Cellular Receptor, and the CD18 β Chain Plays a Functional Role in Fimbrial Signaling 下载免费PDF全文
Akira Takeshita Yukio Murakami Yoshinori Yamashita Masami Ishida Seiichiro Fujisawa Shigeo Kitano Shigemasa Hanazawa 《Infection and immunity》1998,66(9):4056-4060
In this study, we demonstrate that Porphyromonas gingivalis fimbriae use molecules of β2 integrin (CD11/CD18) on mouse peritoneal macrophages as cellular receptors and also show that the β chain (CD18) may play a functional role in signalling for the fimbria-induced expression of interleukin-1β (IL-1β) and tumor necrosis factor alpha (TNF-α) genes in the cells. Using a binding assay with 125I-labeled fimbriae, we observed that fimbrial binding to the macrophages was inhibited by treatment with CD11a, CD11b, CD11c, or CD18 antibody but not by that with CD29 antibody. Western blot assays showed that the fimbriae bound to molecules of β2 integrin (CD11/CD18) on the macrophages. Furthermore, Northern blot analyses showed that the fimbria-induced expression of IL-1β and TNF-α genes in the cells was inhibited strongly by CD18 antibody treatment and slightly by CD11a, CD11b, or CD11c antibody treatment. Interestingly, intracellular adhesion molecule 1 (ICAM-1), a ligand of CD11/CD18, inhibited fimbrial binding to the cells in a dose-dependent manner. In addition, ICAM-1 clearly inhibited the fimbria-induced expression of IL-1β and TNF-α genes in the cells. However, such inhibitory action was not observed with laminin treatment. These results suggest the importance of β2 integrin (CD11/CD18) as a cellular receptor of P. gingivalis fimbriae in the initiation stage of the pathogenic mechanism of the organism in periodontal disease. 相似文献
98.
Ide A Kawasaki E Abiru N Sun F Takahashi R Kuwahara H Fujita N Kita A Oshima K Sakamaki H Uotani S Yamasaki H Yamaguchi Y Eguchi K 《Human immunology》2002,63(8):690-695
This study investigated whether interleukin-10 (IL-10) gene promoter region polymorphisms are associated with susceptibility to or clinical presentation of type 1 diabetes. The frequency of -1082G/A, -819C/T, and -592C/A polymorphisms was analyzed in 128 Japanese patients with type 1 diabetes and in 107 healthy control subjects in a case-controlled study. The allelic and haplotypic frequencies of the IL-10 gene promoter region polymorphisms were similar in patients with type 1 diabetes and in control subjects. However, the -819T and -592A allele were associated with adult-onset (>18 years) of the disease (p = 0.037). Furthermore, the frequency of ATA haplotype was increased in adult-onset patients than that in early-onset patients (< or =18 years; p = 0.037). Among the genotypes comprising ATA haplotype, the frequency of ATA/ATA was significantly higher in adult-onset patients than in early-onset patients (p = 0.004). These results suggest that the IL-10 gene promoter polymorphisms are associated with the age-at-onset in Japanese patients with type 1 diabetes. 相似文献
99.
Functional analysis of PTPN11/SHP-2 mutants identified in Noonan syndrome and childhood leukemia 总被引:3,自引:0,他引:3
Niihori T Aoki Y Ohashi H Kurosawa K Kondoh T Ishikiriyama S Kawame H Kamasaki H Yamanaka T Takada F Nishio K Sakurai M Tamai H Nagashima T Suzuki Y Kure S Fujii K Imaizumi M Matsubara Y 《Journal of human genetics》2005,50(4):192-202
Noonan syndrome (NS) is characterized by short stature, characteristic facial features, and heart defects. Recently, missense mutations of PTPN11, the gene encoding protein tyrosine phosphatase (PTP) SHP-2, were identified in patients with NS. Further, somatic mutations in PTPN11 were detected in childhood leukemia. Recent studies showed that the phosphatase activities of five mutations identified in NS and juvenile myelomonocytic leukemia (JMML) were increased. However, the functional properties of the other mutations remain unidentified. In this study, in order to clarify the differences between the mutations identified in NS and leukemia, we examined the phosphatase activity of 14 mutants of SHP-2. We identified nine mutations, including a novel F71I mutation, in 16 of 41 NS patients and two mutations, including a novel G503V mutation, in three of 29 patients with leukemia. Immune complex phosphatase assays of individual mutants transfected in COS7 cells showed that ten mutants identified in NS and four mutants in leukemia showed 1.4-fold to 12.7-fold increased activation compared with wild-type SHP-2. These results suggest that the pathogenesis of NS and leukemia is associated with enhanced phosphatase activity of mutant SHP-2. A comparison of the phosphatase activity in each mutant and a review of previously reported cases showed that high phosphatase activity observed in mutations at codons 61, 71, 72, and 76 was significantly associated with leukemogenesis. 相似文献
100.
Taiki Matsunaga Yuki Kamachi Koichi Kinoshita Tetsuya Sakamoto Takuaki Yamamoto 《The Journal of arthroplasty》2021,36(2):429-433
BackgroundCurved periacetabular osteotomy (CPO) is performed via an anterior approach without detachment of the hip abductor muscles. This study aimed to evaluate the abductor muscle status shortly after CPO on magnetic resonance imaging (MRI).MethodsWe prospectively evaluated 38 hips in 38 patients 1 week and 3 months after CPO between October 2017 and July 2019. The status of the abductor muscles was assessed on MRI using the following criteria: grade 0, normal; grade I, strain/edema; grade II, partial tear; and grade III, complete tear. We also evaluated associations between muscle status and patients’ characteristics.ResultsOne week after CPO, the gluteus maximus was classified as grade 0 in all patients. The gluteus medius was grade 0 in 84.2% of patients and grade I in 15.8%. The gluteus minimus was grade I in 55.3% of patients and grade II in 44.7%. Three months after CPO, both the gluteus maximus and gluteus medius were grade 0 in all patients, while the gluteus minimus was still grade I in 47.4%. There were no significant differences between patients with a grade 0 and grade I gluteus minimus at 3 months after CPO in patients’ characteristics (age and body mass index) or clinical scores (Harris Hip Score and Japanese Orthopedics Association score).ConclusionBoth the gluteus minimus and medius showed abnormal appearances on MRI 1 week after CPO, whereas only the gluteus minimus showed abnormalities 3 months after CPO. This abductor muscle status did not affect the postoperative Harris Hip Score or Japanese Orthopedics Association score. 相似文献