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991.
Tiehong Zhang Jun Xu Hongchang Shen Wei Dong Yang Ni Jiajun Du 《International journal of clinical and experimental pathology》2015,8(9):11348-11355
Tumor-stroma ratio (TSR) has been identified as a new and practicable prognostic factor in some solid tumors. The aim of the study is to evaluate the prognostic value of TSR in non-small cell lung cancer (NSCLC). A total of 404 patients who underwent surgery resection for NSCLC were included in this study. TSR was assessed visually on the hematoxylin-stained tissue sections of surgical specimens. Patients with more than 50% intratumor stroma were quantified as the stroma-rich group and those with less than 50% as the stroma-poor group. In 404 cases of tissue samples, 302 cases were included in the stroma-poor group, while 102 cases in stroma-rich group. The different expression of TSR in NSCLC tissue was not correlated with gender, age, smoking history, tumor diameter, histology, differentiation grade and pTNM staging. In the Cox univariate and multivariate analyses of the 5-year OS, the HRs of the TSR were 1.818 (95% CI; 1.323-2.497; P<0.001) and 1.748 (95% CI; 1.262-2.422; P<0.05), respectively. As for DFS, the HRs were 1.715 (95% CI; 1.249-2.354; P<0.001) and 1.570 (95% CI; 1.135-2.172; P<0.05). Stroma-rich tumors were associated with poor prognosis and an increased risk of relapse, which may serve as a new prognostic histological characteristic in NSCLC. 相似文献
992.
目的:观察保存时间对3种实验性牙本质粘接处理剂的粘接强度的影响。方法:将3种实验性粘接处理剂10-甲基丙烯酰氧癸基双氢磷酸盐-2-羟乙基丙烯酸酯(MDP-HEMA),MDP-N-甲基丙烯酰甘氨酸(MDP-NMGly),N-甲基丙烯酰-2-氨乙基膦酸-NMGly(NMEP-NMGly)制备后置于40℃保温箱中6周和14周,在不同的保存时期分别测试剪切粘接强度(n=14)和p H值以及断裂模式和扫面电镜观察。结果:经过14周40℃的保存,MDP-HEMA剪切粘接强度由(17.61±1.56)MPa下降到(7.53±1.76)MPa;而MDP-NMGly和NMEP-NMGly则没有显著下降。断裂模式显示经过14周保存的MDP-HEMA和MDP-NMGly以界面破坏为主;而NMEP-NMGly仍然以树脂/牙本质断裂为主。SEM观察保存14周后MDP-HEMA和MDP-NMGly均有树脂与牙本质的分离,而NMEP-NMGly则没有明显的界面分离。结论:NMEP-NMGly具有更好的稳定性。 相似文献
993.
早期穴位按摩配合电动吸乳促进母乳喂养的效果研究 总被引:4,自引:0,他引:4
目的 探讨早期穴位按摩配合电动吸乳对母乳喂养的影响.方法 选择100例产妇 ,随机分为观察组(50例)和对照组(50例) ,对照组采用常规乳房护理 ,观察组在此基础上进行早期穴位按摩配合电动吸乳.记录两组产妇泌乳始动时间 ;产后24h、48h、72h的泌乳量 ;产后2d、3d、4d的乳房肿胀硬度以及产后第5天纯母乳喂养率的情况.结果 观察组产妇泌乳始动时间早于对照组( P<0 .05 );观察组产后24 h、48 h、72 h的泌乳量均多于对照组(P<0 .05);观察组产后第5天纯母乳喂养率明显高于对照组(P<0 .05).结论 基于常规乳房护理的早期穴位按摩配合电动吸乳可增加乳汁分泌 ,促进母乳喂养成功. 相似文献
994.
Genetic association of ACSM1 variation with schizophrenia and major depressive disorder in the Han Chinese population 下载免费PDF全文
995.
996.
目的:应用引进的德国仪器及新技术探讨并建立健康成人错误相关负电位(ERN)的正常值。方法:应用德国Brain Products公司的ERP记录与分析系统,对50例21~55岁健康成人右利手受试者,作了ERN检测。结果:(1)32个头皮记录点皆在约100~150ms处出现了一个负波,健康成人ERN波形较稳定。(2)在Cz、Fz、Pz、C3、C4 5个脑区,建立了健康成人ERN潜伏期和波幅均值。(3)左右侧比较及男女性别比较差异无统计学意义(P>0.05)。结论:健康成人ERN较稳定和可靠。ERN可作为一个有临床推广应用价值的ERP而用于神经精神科临床。 相似文献
997.
Hui-Lian Huang Jian-Fen Shen Li-Shan Min Jin-Liang Ping Yong-Liang Lu Li-Cheng Dai 《International journal of clinical and experimental pathology》2015,8(5):5387-5394
Background: To investigate the inhibitory effect of midkine-binding peptides on human umbilical vein endothelial cells (HUVECs) proliferation and angiogenesis of xenograft tumor. Methods: The midkine-binding peptides were panned by Ph.D.-7™ Phage Display Peptide Library Kit, and the specific binding activities of positive clones to target protein were examined by phage ELISA. The effect of midkine-binding peptides on proliferation of HUVECs was confirmed by MTT test. The xenograft tumor model was formed in BALB/c mice with the murine hepatocarcinoma cells H22 (H22). Microvessel density (MVD) was analyzed by immunohistochemistry of factor VIII staining. Results: Midkine-binding peptides have the inhibitory effects on tumor angiogenesis, a proliferation assay using human umbilical vein endothelial cells (HUVECs) indicated that particular midkine-binding peptides significantly inhibited the proliferation of the HUVECs. Midkine-binding peptides were also observed to efficiently suppress angiogenesis induced by murine hepatocarcinoma H22 cells in BALB/c nude mice. Conclusion: The midkine-binding peptides can inhibit solid tumor growth by retarding the formation of new blood vessels. The results indicate that midkine-binding peptides may represent potent anti-angiogenesis agents in vivo. 相似文献
998.
Jiaojiao Lan Bing Huang Ruixue Liu Xinxin Ju Yang Zhou Jinfang Jiang Weihua Liang Yaoyuan Shen Feng Li Lijuan Pang 《International journal of clinical and experimental pathology》2015,8(10):12621-12633
Objective: Vascular tumor, which belongs to a kind of complicated lesion in soft tissue tumor, is derived from mesenchymal tissue. Although many studies have been focused on the pathogenesis of vascular tumors in human, the specific mechanism of the vascular tumors was currently unclear. Previous studies have reported an association of cancer stem cells with the development of tumor in many solid tumors. Thus the purpose of this study was to explore whether different expression level of cancer stem cell markers including CD29, CD44, CD133, nestin and ALDH1 in vascular tumor may help to elucidate the possible pathogenesis of vascular tumor. In present study, tissues of 9 cases of hemangioma, 22 cases of hemangiosarcoma, 3 cases of Kaposi’s sarcoma, and 5 cases of hemangioendothelioma were immunostained for CD29, CD44, CD133, nestin and ALDH1. Of the 39 vascular tumor cases included in the current study, CD29, CD133 and nestin were positive in most vascular tumor cases. Although CD44 and ALDH1 were observed in vascular tumor cases, the percentage of cells staining for the two markers was less than 2% in all cases of vascular tumor. Capillary hemangiomas exhibited significantly higher expression rate of CD29 and nestin compared with malignant vascular tumors and hemangioendotheliomas (P<0.05, Fisher’s exact test), while CD44, CD133 and ALDH1 exhibited no statistically significant difference between these two groups. Pearson correlation analysis exhibited that CD29 expression and nestin expression in vascular tumor were no statistically significant relationship (C=0.288, P=0.063>0.05). Our findings confirmed that the five cancer stem cells markers, including CD29, CD44, CD133, nestin and ALDH1, exhibited different expression levels in vascular tumors and demonstrated that immonhistochemical analysis for cancer stem cells markers may provide useful information for studying the pathogenesis of vascular tumors. 相似文献
999.
1000.
目的 了解大学生对微笑美学基础知识的了解程度以及需求现状.方法 随机选取120名在读大学生进行问卷调查.在120受试者中随机抽选男女各20位,进行微笑基础知识教育,1周后随访调查.取受试者干预前后2次正面微笑照片被男女各10名大众参与者进行主观评价.结果 从各个问题答案构成比中看出,男女各占比例相差小,但微笑美学基础知识在大学生中迫切需要学习.卡方检验显示受检者主观感知变化结果:对微笑美学基础知识了解改变,干预具有一定效果;专业指导与训练后会变得更好,男性改变明显,女性选择“可能性”的非常多;估计自己微笑理想程度以0~10分的中点5分处分界,对评分数据分析,显示出尚不能认为女性变化明显但整体主观变化明显.大众评价结果显示,尚不能认为女性评价者认为授课后的相片更好看;而男性评价者认为授课后的相片更好看;男女共20名评价结果显示,更倾向于授课后的相片好看.结论 当今大学生迫切需要微笑美学知识这方面的教育,需要进一步发挥正畸医师的社会性作用,即将微笑美学知识面向社会推广. 相似文献