全文获取类型
收费全文 | 25879篇 |
免费 | 1697篇 |
国内免费 | 80篇 |
专业分类
耳鼻咽喉 | 181篇 |
儿科学 | 811篇 |
妇产科学 | 625篇 |
基础医学 | 3924篇 |
口腔科学 | 449篇 |
临床医学 | 3725篇 |
内科学 | 4672篇 |
皮肤病学 | 451篇 |
神经病学 | 2718篇 |
特种医学 | 602篇 |
外科学 | 2126篇 |
综合类 | 173篇 |
一般理论 | 26篇 |
预防医学 | 2976篇 |
眼科学 | 446篇 |
药学 | 1888篇 |
1篇 | |
中国医学 | 58篇 |
肿瘤学 | 1804篇 |
出版年
2023年 | 193篇 |
2022年 | 297篇 |
2021年 | 716篇 |
2020年 | 473篇 |
2019年 | 641篇 |
2018年 | 781篇 |
2017年 | 553篇 |
2016年 | 608篇 |
2015年 | 796篇 |
2014年 | 913篇 |
2013年 | 1465篇 |
2012年 | 2038篇 |
2011年 | 2177篇 |
2010年 | 1134篇 |
2009年 | 1067篇 |
2008年 | 1768篇 |
2007年 | 1838篇 |
2006年 | 1789篇 |
2005年 | 1668篇 |
2004年 | 1583篇 |
2003年 | 1448篇 |
2002年 | 1273篇 |
2001年 | 169篇 |
2000年 | 132篇 |
1999年 | 175篇 |
1998年 | 220篇 |
1997年 | 169篇 |
1996年 | 163篇 |
1995年 | 119篇 |
1994年 | 128篇 |
1993年 | 110篇 |
1992年 | 77篇 |
1991年 | 90篇 |
1990年 | 76篇 |
1989年 | 79篇 |
1988年 | 48篇 |
1987年 | 49篇 |
1986年 | 50篇 |
1985年 | 50篇 |
1984年 | 69篇 |
1983年 | 73篇 |
1982年 | 71篇 |
1981年 | 49篇 |
1980年 | 51篇 |
1979年 | 36篇 |
1978年 | 23篇 |
1977年 | 26篇 |
1976年 | 24篇 |
1975年 | 19篇 |
1974年 | 22篇 |
排序方式: 共有10000条查询结果,搜索用时 375 毫秒
961.
Hanna Kaduszkiewicz Marion Eisele Birgitt Wiese Jana Prokein Melanie Luppa Tobias Luck Frank Jessen Horst Bickel Edelgard M?sch Michael Pentzek Angela Fuchs Sandra Eifflaender-Gorfer Siegfried Weyerer Hans-Helmut K?nig Christian Brettschneider Hendrik van den Bussche Wolfgang Maier Martin Scherer Steffi G. Riedel-Heller The Study on Aging Cognition Dementia in Primary Care Patients Study Group 《Annals of family medicine》2014,12(2):158-165
PURPOSE
The concept of mild cognitive impairment (MCI) has recently been introduced into the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) as mild neurocognitive disorder, making it a formal diagnosis. We investigated the prognostic value of such a diagnosis and analyzed the determinants of the future course of MCI in the AgeCoDe study (German Study on Ageing, Cognition, and Dementia in Primary Care Patients).METHODS
We recruited 357 patients with MCI aged 75 years or older from primary care practices and conducted follow-up with interviews for 3 years. Depending on the course of impairment over time, the patients were retrospectively split into 4 groups representing remittent, fluctuating, stable, and progressive courses of MCI. We performed ordinal logistic regression analysis and classification and regression tree (CART) analysis.RESULTS
Overall, 41.5% of the patients had remission of symptoms with normal cognitive function 1.5 and 3 years later, 21.3% showed a fluctuating course, 14.8% had stable symptoms, and 22.4% had progression to dementia. Patients were at higher risk for advancing from one course to the next along this spectrum if they had symptoms of depression, impairment in more than 1 cognitive domain, or more severe cognitive impairment, or were older. The result on a test of the ability to learn and reproduce new material 10 minutes later was the best indicator at baseline for differentiating between remittent and progressive MCI. Symptoms of depression modified the prognosis.CONCLUSIONS
In primary care, about one-quarter of patients with MCI have progression to dementia within the next 3 years. Assessments of memory function and depressive symptoms are helpful in predicting a progressive vs a remittent course. When transferring the concept of MCI into clinical diagnostic algorithms (eg, DSM-5), however, we should not forget that three-quarters of patients with MCI stayed cognitively stable or even improved within 3 years. They should not be alarmed unnecessarily by receiving such a diagnosis. 相似文献962.
G. Feljandro P. Ramos Antoinette D. I. van Asselt Sandra Kuiper Johan L. Severens Tanja Maas Edward Dompeling J. André Knottnerus Onno C. P. van Schayck 《The European journal of health economics》2014,15(8):869-883
Background
Many children stand to benefit from being asthma-free for life with primary (i.e., prenatally started) prevention addressing one environmental exposure in a unifaceted (UF) approach or at least two in a multifaceted (MF) approach. We assessed the cost-effectiveness of primary prevention programmes for Dutch children in a decision-analytic framework.Methods
A decision-analytic tree model analysing healthcare costs and asthma cases prevented was developed to compare usual care (UC) with two UF and three MF programmes on the primary prevention of asthma amongst children. Programmes were evaluated through incremental cost-effectiveness ratios and net monetary benefits. Decision and parameter uncertainty were subjected to value-of-information analyses.Results
The current UC and one of three MF programmes dominated the other alternatives. The MF programme was more costly but also more effective than UC at an incremental cost-effectiveness ratio of €8,209.20/additional asthma case prevented. The value of perfect information to reduce uncertainty was €291.6M at its lowest. Most of the uncertainty in the cost-effectiveness threshold was attributable to the probability and cost estimates for low-risk children.Conclusion
This study supports the feasibility of a structured programme that simultaneously addresses exposure to house dust mites, pet dander, environmental tobacco, and breast-feeding as a cost-effective alternative to UC in the primary prevention of asthma amongst children. 相似文献963.
Sandra M. Vioque Patrick K. Kim Janet McMaster John Gallagher Steven R. Allen Daniel N. Holena Patrick M. Reilly Jose L. Pascual 《American journal of surgery》2014
Background
Benchmarking and classification of avoidable errors in trauma care are difficult as most reports classify errors using variable locally derived schemes. We sought to classify errors in a large trauma population using standardized Joint Commission taxonomy.Methods
All preventable/potentially preventable deaths identified at an urban, level-1 trauma center (January 2002 to December 2010) were abstracted from the trauma registry. Errors deemed avoidable were classified within the 5-node (impact, type, domain, cause, and prevention) Joint Commission taxonomy.Results
Of the 377 deaths in 11,100 trauma contacts, 106 (7.7%) were preventable/potentially preventable deaths related to 142 avoidable errors. Most common error types were in clinical performance (inaccurate diagnosis). Error domain involved primarily the emergency department (therapeutic interventions), caused mostly by knowledge deficits. Communication improvement was the most common mitigation strategy.Conclusion
Standardized classification of errors in preventable trauma deaths most often involve clinical performance in the early phases of care and can be mitigated with universal strategies. 相似文献964.
Alexander Iribarne Helena Chang John H. Alexander A. Marc Gillinov Ellen Moquete John D. Puskas Emilia Bagiella Michael A. Acker Mary Lou Mayer T. Bruce Ferguson Sandra Burks Louis P. Perrault Stacey Welsh Karen C. Johnston Mandy Murphy Joseph J. DeRose Alexis Neill Edlira Dobrev Kim T. Baio Wendy Taddei-Peters Alan J. Moskowitz Patrick T. O’Gara 《The Annals of thoracic surgery》2014
965.
Electroencephalography (EEG) has, historically, played a focal role in the assessment of neural function in children with attention deficit hyperactivity disorder (ADHD). We review here the most recent developments in the utility of EEG in the diagnosis of ADHD, with emphasis on the most commonly used and emerging EEG metrics and their reliability in diagnostic classification. Considering the clinical heterogeneity of ADHD and the complexity of information available from the EEG signals, we suggest that considerable benefits are to be gained from multivariate analyses and a focus towards understanding of the neural generators of EEG. We conclude that while EEG cannot currently be used as a diagnostic tool, vast developments in analytical and technological tools in its domain anticipate future progress in its utility in the clinical setting. 相似文献
966.
Amy A. Herrold ;Sandra L. Kletzel ;Brett C. Harton ;R. Andrew Chambers ;Neil Jordan ;Theresa Louise-Bender Pape 《中国神经再生研究》2014,9(19):1712-1730
Alcohol use disorder (AUD), mild traumatic brain injury (mTBI), and posttraumatic stress disorder (PTSD) commonly co-occur (AUD + mTBI + PTSD). These conditions have overlapping symptoms which are, in part, reflective of overlapping neuropathology. These conditions become problematic because their co-occurrence can exacerbate symptoms. Therefore, treatments must be developed that are inclusive to all three conditions. Repetitive transcranial magnetic stimulation (rTMS) is non-invasive and may be an ideal treatment for co-occurring AUD + mTBI + PTSD. There is accumulating evidence on rTMS as a treatment for people with AUD, mTBI, and PTSD each alone. However, there are no published studies to date on rTMS as a treatment for co-occurring AUD + mTBI + PTSD. This review article advances the knowledge base for rTMS as a treatment for AUD + mTBI + PTSD. This review provides background information about these co-occurring conditions as well as rTMS. The existing literature on rTMS as a treatment for people with AUD, TBI, and PTSD each alone is reviewed. Finally, neurobiological findings in support of a theoretical model are discussed to inform TMS as a treatment for co-occurring AUD + mTBI + PTSD. The peer-reviewed literature was identified by targeted literature searches using PubMed and supplemented by cross-referencing the bibliographies of relevant review articles. The existing evidence on rTMS as a treatment for these conditions in isolation, coupled with the overlapping neuropathology and symptomology of these conditions, suggests that rTMS may be well suited for the treatment of these conditions together. 相似文献
967.
968.
969.
Michael A. Jhung Tiffany D'Mello Alejandro Pérez Deborah Aragon Nancy M. Bennett Tara Cooper Monica M. Farley Brian Fowler Stephen M. Grube Emily B. Hancock Ruth Lynfield Craig Morin Arthur Reingold Patricia Ryan William Schaffner Ruta Sharangpani Leslie Tengelsen Ann Thomas Diana Thurston Kimberly Yousey-Hindes Shelley Zansky Lyn Finelli Sandra S. Chaves 《American journal of infection control》2014
970.