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81.
Is Internet-based support for dyspnea self-management in patients with chronic obstructive pulmonary disease possible? Results of a pilot study 总被引:1,自引:0,他引:1
Nguyen HQ Carrieri-Kohlman V Rankin SH Slaughter R Stulbarg MS 《Heart & lung : the journal of critical care》2005,34(1):51-62
BACKGROUND: As of 2003, approximately 67% of US adults have Internet access. The purpose of this study was to determine the feasibility and preliminary efficacy of an Internet-based dyspnea self-management program (iDSMP) for people with chronic obstructive pulmonary disease. A related aim was to compare the differential effects of the iDSMP on 2 different groups: (1) to test a "booster" effect and (2) to evaluate the program as a primary intervention. METHODS: Two groups (n = 16) were evaluated at baseline and at 3 months after completing the iDSMP, which included education, exercise, self-monitoring, and support. Dyspnea, self-efficacy, perception of available support, and exercise behavior were measured. Paired, independent t tests and Mann-Whitney U tests were used. RESULTS: Most subjects (87%) reported that the program increased their access to information and resources for managing dyspnea. Dyspnea with activities of daily living and self-efficacy for managing the symptom showed significant improvements (both P < .01), whereas more modest changes were noted in perceived support and exercise behavior in the overall sample. There were no differences between the 2 groups on these outcomes. CONCLUSIONS: The findings suggest that additional investigations of Internet-based interventions to promote self-management in patients with chronic obstructive pulmonary disease are warranted. 相似文献
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Hargreaves S 《Lancet》2002,359(9308):793-794
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Dr. Gordon W. Philpott M.D. Barry A. Siegel M.D. Sally W. Schwarz M.S. R.Ph. Judith M. Connett Ph.D. Pamela A. Rocque B.S. James W. Fleshman M.D. Jerold W. Wallis M.D. Mary Baumann B.S. Yizhen Sun Ph.D. Arthur E. Martell Ph.D. Michael J. Welch Ph.D. 《Diseases of the colon and rectum》1994,37(8):782-792
PURPOSE: This study was designed to evaluate a new anticolorectal carcinoma monoclonal antibody (1A3), conjugated with the bifunctional chelating agent N,N′-bis (2-hydroxybenzyl) 1 (4-bromoacetamidobenzyl) 1,2-ethylenediamine-N,N′-diacetic acid and labeled with indium-111, in a Phase I/II study involving 38 patients with localized or advanced colorectal cancer. METHODS: Patients were injected with indium-111-N,N′-bis(2-hydroxybenzyl) 1 (4-bromoacetamidobenzyl) 1,2-ethylenediamine-N, N′-diacetic acid-monoclonal antibody 1A3 (1–50 mg, 1–5 mCi) and imaged at two or three sessions one to five days later. Scintigraphic findings were compared with radiologic, pathologic, surgical, and other clinical findings to assess the accuracy of radioimmunoscintigraphy. RESULTS: At least one known tumor site was clearly defined by planar scintigraphy in 29 (76 percent) patients. Increased radioactivity was seen in 40 of 63 known tumor sites (37/43 abdominal-pelvic, 3/15 hepatic, and 0/5 pulmonary sites) without any apparent dose-related effects. Nineteen previously undetected sites were considered positive by imaging, and, of these, six were biopsy-proven tumor sites, four were probable tumor sites, three were definitely false positive sites, and six were probable false positive sites. Radioimmunoscintigraphy detected proven tumor in 15 of 16 patients with negative or equivocal computed tomography results. Of the 28 patients with rectosigmoid cancer, 25 (89 percent) had positive studies with 34 of 47 tumor sites showing definite uptake on the scintigrams. This included 3 of 9 hepatic metastases. The only adverse reaction occurred in one patient who developed transient hives. Human anti-mouse antibody responses occurred in approximately one-half of the patients injected with doses of 10 or 50 mg. CONCLUSION: This study shows that radioimmunoscintigraphy with this indium-111-labeled monoclonal antibody is safe, it can detect most nonhepatic abdominalpelvic tumors with a positive predictive value of 83 (44/ 53) percent, and it should prove to be useful, particularly in the diagnosis of recurrent rectal carcinoma. 相似文献
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JPMHN report on the 2018 Skellern Lecture and JPHMN Lifetime Achievement Award—held at the University of Greenwich Maritime Campus,June 14th 2018 下载免费PDF全文
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Rachel Dolin Pam Silberman Denise A. Kirk Sally C. Stearns Laura C. Hanson Donald H. Taylor G. Mark Holmes 《Journal of pain and symptom management》2018,55(3):775-784
Context
The rate of live discharge from hospice and the proportion of hospices exceeding their aggregate caps have both increased for the last 15 years, becoming a source of federal scrutiny. The cap restricts aggregate payments hospices receive from Medicare during a 12-month period. The risk of repayment and the manner in which the cap is calculated may incentivize hospices coming close to their cap ceilings to discharge existing patients before the end of the cap year.Objective
The objective of this work was to explore annual cap-risk trends and live discharge patterns. We hypothesized that as a hospice comes closer to exceeding its cap, a patient's likelihood of being discharged alive increases.Methods
We analyzed monthly hospice outcomes using 2012–2013 Medicare claims.Results
Adjusted analyses showed a positive and statistically significant relationship between cap risk and live discharges.Conclusion
Policymakers ought to consider the unintended consequences the aggregate cap may be having on patient outcomes of care. 相似文献89.
Toyonaga Takahiko Kobayashi Taku Kuronuma Satoshi Ueno Aito Kiyohara Hiroki Okabayashi Shinji Takeuchi Osamu Redfern Christopher P. F. Terai Hideki Ozaki Ryo Sagami Shintaro Nakano Masaru Coulthard Sally A. Tanaka Yoichi Hibi Toshifumi 《Journal of gastroenterology》2021,56(11):999-1007
Journal of Gastroenterology - Polymorphisms in the nucleotide diphosphate-linked moiety X-type motif 15 (NUDT15) gene are associated with thiopurine-induced leukopenia in patients with inflammatory... 相似文献
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