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81.
Kelly L Conrad Adeola R Davis Yuval Silberman Douglas J Sheffler Angela D Shields Sam A Saleh Namita Sen Heinrich JG Matthies Jonathan A Javitch Craig W Lindsley Danny G Winder 《Neuropsychopharmacology》2012,37(10):2253-2266
The alpha2 adrenergic receptor (α2-AR) antagonist yohimbine is a widely used tool for the study of anxiogenesis and stress-induced drug-seeking behavior. We previously demonstrated that yohimbine paradoxically depresses excitatory transmission in the bed nucleus of the stria terminalis (BNST), a region critical to the integration of stress and reward pathways, and produces an impairment of extinction of cocaine-conditioned place preference (cocaine-CPP) independent of α2-AR signaling. Recent studies show yohimbine-induced drug-seeking behavior is attenuated by orexin receptor 1 (OX1R) antagonists. Moreover, yohimbine-induced cocaine-seeking behavior is BNST-dependent. Here, we investigated yohimbine-orexin interactions. Our results demonstrate yohimbine-induced depression of excitatory transmission in the BNST is unaffected by alpha1-AR and corticotropin-releasing factor receptor-1 (CRFR1) antagonists, but is (1) blocked by OxR antagonists and (2) absent in brain slices from orexin knockout mice. Although the actions of yohimbine were not mimicked by the norepinephrine transporter blocker reboxetine, they were by exogenously applied orexin A. We find that, as with yohimbine, orexin A depression of excitatory transmission in BNST is OX1R–dependent. Finally, we find these ex vivo effects are paralleled in vivo, as yohimbine-induced impairment of cocaine-CPP extinction is blocked by a systemically administered OX1R antagonist. These data highlight a new mechanism for orexin on excitatory anxiety circuits and demonstrate that some of the actions of yohimbine may be directly dependent upon orexin signaling and independent of norepinephrine and CRF in the BNST. 相似文献
82.
Omar Kujan Ibrahim Alzoghaibi Saleh Azzeghaiby Mohammed Alsakran Altamimi Bassel Tarakji Salah Hanouneh Majdy Idress Faris Q Alenzi Mazhar Iqbal Shahama Taifour 《Journal of cancer education》2014,29(4):735-738
Oral cancer awareness among future dental practitioners may have an impact on the early detection and prevention of oral cancer. A cross-sectional survey was undertaken to assess the current knowledge of future Saudi dentists on oral cancer and their opinions on oral cancer prevention. A pretested questionnaire was sent to 550 undergraduate dental students in the fourth, fifth, and sixth year of the Al-Farabi College for Dentistry and Nursing, Riyadh, Saudi Arabia. Questions relating to knowledge of oral cancer, risk factors, and opinions on oral cancer prevention and practices were posed. Four hundred seventy-nine students returned the questionnaire (87.1 %). Eighty-one percent of respondents correctly answered questions relating to oral cancer awareness. Eighty-seven percent of respondents felt confident in performing a systematic oral examination to detect changes consistent with oral malignancy. Interestingly, 57 % of respondents had seen the use of oral cancer diagnostics aids. Thirty-seven percent of respondents felt inadequately trained to provide tobacco and alcohol cessation advice. There is a need to reinforce the undergraduate dental curriculum with regards to oral cancer education; particularly in its prevention and early detection. Incorporating the use of oral cancer diagnostic aids should be made mandatory. 相似文献
83.
The aim of this study was to determine the values of some metabolites, ions, and enzymes in maternal blood serum and fetal fluids in relation to gestation day in cattle. Gravid uteri of cattle were collected after slaughter. The allantoic and amniotic fluids as well as maternal blood samples were collected. Fetal ages were determined according to crown–rump length by applying the age estimation formula that previously was presented for cattle. The pregnancies were divided according to gestation days into four groups: 0–50, 51–100, 101–150, and 151–200?days. With the progress of pregnancy, the biochemical levels of fetal fluids and maternal serum changed as follows: there was a rise of total protein, urea, creatinine, and alkaline phosphatase values in fetal fluids and serum; the levels of glucose in maternal serum and potassium in fetal fluids increased; cholesterol, triglyceride, phosphorus, and sodium contents of fetal fluids and serum decreased; the concentrations of glucose and calcium in fetal fluids, lactate dehydrogenase (LDH) in serum and allantoic fluid, potassium in serum, and aspartate aminotransferase (ASAT) in amniotic fluid and serum dropped. The values of LDH in amniotic fluid, ASAT in allantoic fluid, alanine aminotransferase in amniotic and allantoic fluids, and calcium in maternal serum remained unchanged. 相似文献
84.
85.
Mervat M El-Eshmawy Eman H El-Adawy Amany A Mousa Amany E Zeidan Azza A El-Baiomy Elham R Abdel-Samie Omayma M Saleh 《BMC women's health》2011,11(1):1
Background
Neutrophil elastase level/activity is elevated in a variety of diseases such as atherosclerosis, systolic hypertension and obstructive pulmonary disease. It is unknown whether obese individuals with prehypertension also have elevated neutrophil elastase, and if so, whether it has a deleterious effect on pulmonary function. Objectives: To determine neutrophil elastase levels in obese prehypertensive women and investigate correlations with pulmonary function tests. 相似文献86.
Naiema K. Ali Ragaa R. Mohamed Bothina E. Saleh Manal M. Alkady Eman S. Farag 《Arab Journal Of Gastroenterology》2018,19(3):101-105
Background and study aims
Hepatitis C virus (HCV) infection is a severe problem among patients on maintenance haemodialysis who are at particular risk for blood-borne infections because of prolonged vascular access and potential for exposure to contaminated equipment. Occult hepatitis C virus infection (OCI) is defined as the presence of HCV RNA in liver or peripheral blood mononuclear cells (PBMCs) in the absence of detectable HCV antibody or HCV RNA in the serum. In this study, we aimed to investigate the existence of occult hepatitis C virus infection in PBMCs of haemodialysis (HD) patients in one center. Moreover, we tried to link the condition to risk factors associated with HCV infection in those patients.Patients and methods
We included 40 patients with renal diseases undergoing regular haemodialysis who were repeatedly anti-HCV negative. HCV RNA detection was tested by Quantitative Real time PCR in serum and PBMCs.Results
The results of this study revealed that 23% of our haemodialysis patients have occult hepatitis C virus infection. There was a highly significant increase in ALT levels in patients with OCI versus the negative group. Also, there is a significant increase of history of blood transfusion in patients with occult HCV (p?=?0.03) while the duration of haemodialysis showed no statistical significant difference between both groups. The viral load of the occult hepatitis C virus infection subjects ranged from 581to 74,307 copies/ml.Conclusion
These results highlight the potential risk of hepatitis C virus transmission from patients within haemodialysis units in Egypt. Isolation of patients on dialysis machines depending on the results of hepatitis serological markers is not enough. Testing for hepatitis C virus -RNA in peripheral blood mononuclear cells is more reliable in identifying patients with an OCI when a liver biopsy is not available. 相似文献87.
88.
89.
N Alrashdi Mousa Saleh Alanazi Majed Khalid Almoaqly Alshaya Abdulrahman Khaled Alanazi Sultan Mahja Marzouq 《Clinical rheumatology》2022,41(5):1577-1582
Clinical Rheumatology - Coronavirus disease-19 (COVID-19) is a global pandemic that is caused by COVID-19 virus, which was initially identified in December 2019 in Wuhan, China. Vaccination is one... 相似文献
90.
Saleh A. Al Obeidan 《Saudi Journal of Ophthalmology》2015,29(2):95-102