全文获取类型
收费全文 | 1263篇 |
免费 | 100篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 43篇 |
儿科学 | 21篇 |
妇产科学 | 8篇 |
基础医学 | 139篇 |
口腔科学 | 21篇 |
临床医学 | 150篇 |
内科学 | 260篇 |
皮肤病学 | 7篇 |
神经病学 | 92篇 |
特种医学 | 41篇 |
外科学 | 227篇 |
综合类 | 18篇 |
预防医学 | 65篇 |
眼科学 | 29篇 |
药学 | 84篇 |
中国医学 | 8篇 |
肿瘤学 | 153篇 |
出版年
2023年 | 14篇 |
2022年 | 47篇 |
2021年 | 87篇 |
2020年 | 44篇 |
2019年 | 57篇 |
2018年 | 73篇 |
2017年 | 53篇 |
2016年 | 55篇 |
2015年 | 55篇 |
2014年 | 57篇 |
2013年 | 58篇 |
2012年 | 111篇 |
2011年 | 98篇 |
2010年 | 45篇 |
2009年 | 43篇 |
2008年 | 54篇 |
2007年 | 51篇 |
2006年 | 44篇 |
2005年 | 47篇 |
2004年 | 38篇 |
2003年 | 41篇 |
2002年 | 32篇 |
2001年 | 14篇 |
2000年 | 11篇 |
1999年 | 11篇 |
1998年 | 3篇 |
1997年 | 4篇 |
1995年 | 4篇 |
1993年 | 2篇 |
1992年 | 6篇 |
1991年 | 10篇 |
1990年 | 10篇 |
1989年 | 7篇 |
1988年 | 5篇 |
1987年 | 5篇 |
1986年 | 7篇 |
1985年 | 7篇 |
1984年 | 5篇 |
1983年 | 9篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1980年 | 7篇 |
1979年 | 4篇 |
1978年 | 4篇 |
1977年 | 3篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1974年 | 2篇 |
1972年 | 2篇 |
1967年 | 2篇 |
排序方式: 共有1366条查询结果,搜索用时 0 毫秒
21.
22.
Timothy Gatheral Neelam Kumar Ben Sansom Dilys Lai Arjun Nair Ioannis Vlahos 《COPD》2014,11(6):605-614
Background: COPD and radiographic bronchiectasis frequently coexist but the effect of this on the clinical course of COPD is not fully understood. We determined the impact of bronchiectasis on clinical outcomes in COPD patients, independent of coexisting emphysema and bronchial wall thickening (BWT). Methods: COPD patients admitted with first exacerbation 1998–2008 were identified retrospectively using ICD10 codes J44.0,1,8,9. Patients with suitable CT scans were graded for severity of bronchiectasis, emphysema and BWT on a 5 point scale (0-absent, 1-minor, 2-mild, 3-moderate, 4-severe). Results: 406 patients (71 ± 11 years, 56% male, FEV1 52 ± 23% predicted) were included; 278 (69%) patients had bronchiectasis: minor, 112 (40%); mild, 81 (29%); moderate, 62 (22%); severe 23 (8%). Bronchiectasis severity correlated with severity of BWT (p < 0.001) but not emphysema (p = 0.090). Bronchiectasis independently determined sputum isolation of Pseudomonas aeruginosa (Odds ratio (OR) 1.39 (95% CI 1.07 to 1.80), p = 0.013) and atypical mycobacteria (OR 2.44 (95% CI 1.04 to 5.69), p = 0.040), annual respiratory admissions (p = 0.044) and inpatient days (p < 0.001), but did not predict survival (p = 0.256). Conclusions: Radiographic bronchiectasis in COPD patients is associated with increased respiratory infection and hospitalisation, independent of coexisting emphysema and BWT. COPD-related bronchiectasis is therefore an important diagnosis with potential implications for treatment. 相似文献
23.
A. R. Pradeep Santosh S. Martande Sonender Pal Singh Deepak Kumar Suke Arjun P. Raju Savitha B. Naik 《Inflammation research》2014,63(4):317-323
Objective
The aim of the present study was to evaluate the levels and correlation of human S100A12 and high-sensitivity C-reactive protein (hs-CRP) in gingival crevicular fluid (GCF) and serum in chronic periodontitis (CP) subjects with and without type 2 diabetes mellitus (DM).Materials and methods
A total of 44 subjects were divided into three groups: group 1 had 10 periodontally healthy subjects, group 2 consisted of 17 CP subjects and group 3 had 17 type 2 DM subjects with CP. GCF and serum levels of human S100A12 and hs-CRP were quantified using enzyme-linked immunosorbent assay and immunoturbidimetric analysis, respectively. The clinical outcomes evaluated were gingival index, probing depth and clinical attachment level and the correlations of the two inflammatory mediators with clinical parameters were evaluated.Results
Both human S100A12 and hs-CRP levels increased from group 1 to group 2 to group 3. The GCF and serum values of both these inflammatory mediators correlated positively with each other and with the periodontal parameters evaluated (p < 0.05).Conclusion
Human S100A12 and hs-CRP can be considered as possible GCF and serum markers of inflammatory activity in CP and DM. 相似文献24.
Randomized clinical trials support the use of implantable defibrillators for mortality reduction in specific populations at high risk for sudden cardiac death. Conventional transvenous defibrillator systems are limited by implantation-associated complications, infection, and lead failure, which may lead to delivery of inappropriate shocks and diminish survival. The development of a fully subcutaneous defibrillator may represent a valuable addition to therapies targeted at sudden death prevention. The PubMed database was searched to identify all clinical reports of the subcutaneous defibrillator from 2000 to the present. We reviewed all case series, cohort analyses, and randomized trials evaluating the safety and efficacy of subcutaneous defibrillators. The subcutaneous defibrillator is a feasible development in sudden cardiac death therapy and may be useful particularly to extend defibrillator therapy to patients with complicated anatomy, limited vascular access, and congenital disease. The subcutaneous defibrillator should not be considered in patients with an indication for cardiac pacing or who have ventricular tachycardia responsive to antitachycardia pacing. Further investigation is needed to compare long-term, head-to-head performance of subcutaneous defibrillators and conventional transvenous defibrillator systems. 相似文献
25.
26.
27.
28.
Policymakers have prioritized the prevention of healthcare-associated infections (HAIs) as a double-win that can both improve health outcomes and reduce healthcare costs. In the past few years, state and federal policymakers have developed policies to improve coordination and promote transparency and prevention. At the federal level, congressional oversight, policy directives, and targeted funding have helped focus national HAI prevention efforts through the Department of Health and Human Services Action Plan to Prevent Healthcare-Associated Infections. The development of this action plan and the collaboration of its implementing agencies-the Centers for Disease Control and Prevention, the Centers for Medicare and Medicaid Services, and the Agency for Healthcare Research and Quality-have heightened nationwide awareness of HAIs and their preventability, and provided an infrastructure and tools to reduce HAIs. State policymakers have also acted to promote local transparency and tailor prevention efforts to local needs. The collaboration and action generated by these state and federal efforts have helped accelerate HAI prevention across the United States. 相似文献
29.
30.
Dipal Mehta Daniel M Jones Avirup Guha Peter K MacCallum Amitava Banerjee Charlotte Manisty Thomas Crake Mark Westwood Arjun K Ghosh 《The British Journal of Cardiology》2020,27(4)
Stroke prophylaxis in atrial fibrillation is an important consideration in patients with cancer. However, there is little consensus on the choice of anticoagulation, due to the numerous difficulties associated with active cancer. Direct oral anticoagulants (DOACs) have been shown to be a promising option. Here, we conduct a simple cross-sectional analysis of 29 cancer patients receiving DOACs for stroke prophylaxis in atrial fibrillation at a tertiary-care institution in London. Our study demonstrates an encouraging efficacy and safety profile of DOACs used in this setting. We conclude by suggesting that, while DOACs may be useful, anticoagulation in cancer patients should continue to be individualised. 相似文献